Hydrophobic core/hydrophilic shell platelet glycoprotein IIb/IIIa receptor monoclonal antibody (SZ-21)/docetaxel (DTX) dual-drug loaded stents exhibiting a uniform coating of nano/micro particles using coaxial electrospray were prepared. Experimental data combined with a biphasic mathematical model indicated the release of the two drugs conformed to a diffusion-controlled release system. The core/shell SZ-21/DTX dual-drug loaded stents showed good blood and cell compatibility, promoted re-endothelialization in vivo and reduced in-stent restenosis in porcine coronary arteries. The coaxial electrospray technique is a one-step and effective technique for stent coating with multiple drugs and has great potential for helping to create the enhanced implants of the future.
- Ruolin Du
- Yazhou Wang
- Guixue Wang
