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Identification of undetected SARS-CoV-2 infections by clustering of Nucleocapsid antibody trajectories

Many SARS-CoV-2 infections may go undetected through conventional PCR or lateral flow tests. Here, the authors analyse the utility of analysing longitudinal nucleocapsid antibody trajectories to improve identification of prior SARS-CoV-2 infections using surveillance data from the UK.

Leslie R. Zwerwer
Tim E. A. Peto
Chris Cunningham
ResearchOpen Access14 May 2025
Nature Communications

Volume: 16, P: 1-13
Effect of Delta variant on viral burden and vaccine effectiveness against new SARS-CoV-2 infections in the UK

A large, community-based study in the United Kingdom indicates that the effectiveness of BNT162b2 and ChAdOx1 vaccines against SARS-CoV-2 infections with symptoms or high viral burden is reduced with the Delta variant compared to the Alpha variant.

Koen B. Pouwels
Emma Pritchard
A. Sarah Walker
ResearchOpen Access14 Oct 2021
Nature Medicine

Volume: 27, P: 2127-2135
Risk of SARS-CoV-2 reinfection during multiple Omicron variant waves in the UK general population

The factors influencing risk of reinfection with SARS-CoV-2 are poorly understood. Here, the authors use data from the UK COVID-19 Infection Survey, a community based longitudinal study, to assess characteristics of ~45,000 reinfections compared to initial infections.

Jia Wei
Nicole Stoesser
Chris Cunningham
ResearchOpen Access02 Feb 2024
Nature Communications

Volume: 15, P: 1-14
Improving the representativeness of UK’s national COVID-19 Infection Survey through spatio-temporal regression and post-stratification

Estimates of infection rates from the UK COVID-19 Infection Survey may have been biased by the characteristics of people who chose to take part. Here, the authors show that the survey population had unusually high vaccination rates and adjust infection estimates taking this into account.

Koen B. Pouwels
David W. Eyre
Chris Cunningham
ResearchOpen Access24 Jun 2024
Nature Communications

Volume: 15, P: 1-12
A Study of Galactose Intolerance in Human and Rat Liver In Vivo by ³¹P Magnetic Resonance Spectroscopy

Bella Kalderon
Ruth M Dixon
George K Radda
Research01 Jul 1992
Pediatric Research

Volume: 32, P: 39-44
Prevalence of persistent SARS-CoV-2 in a large community surveillance study

Using viral sequence data, individuals with persistent SARS-CoV-2 infections were identified, and had higher odds of self-reporting long COVID, in a large community surveillance study.

Mahan Ghafari
Matthew Hall
Katrina Lythgoe
ResearchOpen Access21 Feb 2024
Nature

Volume: 626, P: 1094-1101
SARS-CoV-2 antibody trajectories after a single COVID-19 vaccination with and without prior infection

The impact of prior infection on the immune response to COVID-19 vaccination has not been fully characterised. Here, the authors use data from ~100,000 adults in the UK and find that a single vaccine dose in those with prior infection produces a comparable or stronger response to two doses in those without infection.

Jia Wei
Philippa C. Matthews
Chris Cunningham
ResearchOpen Access29 Jun 2022
Nature Communications

Volume: 13, P: 1-9
Anti-spike antibody response to natural SARS-CoV-2 infection in the general population

Most people who are infected with SARS-CoV-2 seroconvert within a few weeks, but the determinants and duration of the antibody response are not known. Here, the authors characterise these features of the immune response using data from a large representative community sample of the UK population.

Jia Wei
Philippa C. Matthews
Chris Cunningham
ResearchOpen Access29 Oct 2021
Nature Communications

Volume: 12, P: 1-12
Antibody responses to SARS-CoV-2 vaccines in 45,965 adults from the general population of the United Kingdom

Longitudinal tracing of antibody responses to the ChAdOx1 and the BNT162b2 COVID-19 vaccines in 45,965 adults from the United Kingdom give indications for vaccine prioritization.

Jia Wei
Nicole Stoesser
Jessica Lee
ResearchOpen Access21 Jul 2021
Nature Microbiology

Volume: 6, P: 1140-1149
Impact of vaccination on new SARS-CoV-2 infections in the United Kingdom

Results from the Office of National Statistics COVID-19 Infection Survey in the United Kingdom demonstrate that the ChAdOx1 nCoV-19 and BNT162b2 vaccines reduce the incidence of new SARS-CoV-2 infections by up to 65% with a single dose and up to 80% after two doses, with no significant differences in efficacy observed between the two vaccines.

Emma Pritchard
Philippa C. Matthews
Koen B. Pouwels
ResearchOpen Access09 Jun 2021
Nature Medicine

Volume: 27, P: 1370-1378
Protection against SARS-CoV-2 Omicron BA.4/5 variant following booster vaccination or breakthrough infection in the UK

The duration and strength of protection against SARS-CoV-2 infection resulting from a booster vaccine dose or breakthrough infection are not well understood. This study uses data from the UK COVID-19 Infection Survey to investigate correlates of protection against Omicron BA.4/5 infection and assess antibody responses to booster vaccination and breakthrough infections.

Jia Wei
Philippa C. Matthews
Chris Cunningham
ResearchOpen Access16 May 2023
Nature Communications

Volume: 14, P: 1-15
Antibody responses and correlates of protection in the general population after two doses of the ChAdOx1 or BNT162b2 vaccines

A large study in the United Kingdom shows that virus-specific antibody levels associated with at least 67% protection against SARS-CoV-2 Delta variant infection last longer after two doses of BNT162b2 vaccine than after two doses of ChAdOx1 vaccine in previously uninfected individuals.

Jia Wei
Koen B. Pouwels
Chris Cunningham
ResearchOpen Access14 Feb 2022
Nature Medicine

Volume: 28, P: 1072-1082
COVID-19 vaccination, risk-compensatory behaviours, and contacts in the UK

John Buckell
Joel Jones
Helen Fryer
ResearchOpen Access25 May 2023
Scientific Reports

Volume: 13, P: 1-15

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Identification of undetected SARS-CoV-2 infections by clustering of Nucleocapsid antibody trajectories

Effect of Delta variant on viral burden and vaccine effectiveness against new SARS-CoV-2 infections in the UK

Risk of SARS-CoV-2 reinfection during multiple Omicron variant waves in the UK general population

Improving the representativeness of UK’s national COVID-19 Infection Survey through spatio-temporal regression and post-stratification

A Study of Galactose Intolerance in Human and Rat Liver In Vivo by ³¹P Magnetic Resonance Spectroscopy

Prevalence of persistent SARS-CoV-2 in a large community surveillance study

SARS-CoV-2 antibody trajectories after a single COVID-19 vaccination with and without prior infection

Anti-spike antibody response to natural SARS-CoV-2 infection in the general population

Antibody responses to SARS-CoV-2 vaccines in 45,965 adults from the general population of the United Kingdom

Impact of vaccination on new SARS-CoV-2 infections in the United Kingdom

Protection against SARS-CoV-2 Omicron BA.4/5 variant following booster vaccination or breakthrough infection in the UK

Antibody responses and correlates of protection in the general population after two doses of the ChAdOx1 or BNT162b2 vaccines

COVID-19 vaccination, risk-compensatory behaviours, and contacts in the UK

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