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Showing 1–7 of 7 results
Advanced filters: Author: Ryan Geusz Clear advanced filters

  • Enhancers for endodermal organs are primed at the chromatin level prior to lineage induction by FOXA pioneer transcription factors; how pervasive this is, is not well known. Here the authors show that only a small subset of organ-specific enhancers are bound and primed by FOXA prior to lineage induction, whereas the majority do not undergo chromatin priming and engage FOXA upon lineage induction.

    • Ryan J. Geusz
    • Allen Wang
    • Maike Sander
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-19

  • How epigenetic regulation affects pancreatic development is unclear. Here, the authors show that the histone demethylase LSD1 regulates the epigenetic state of developmental enhancers during pancreatic specification and controls how these enhancers respond to extracellular signals, namely retinoic acid.

    • Nicholas K. Vinckier
    • Nisha A. Patel
    • Maike Sander
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-15

  • Biomphalaria glabrata is a fresh water snail that acts as a host for trematode Schistosoma mansoni that causes intestinal infection in human. This work describes the genome and transcriptome analyses from 12 different tissues of B glabrata, and identify genes for snail behavior and evolution.

    • Coen M. Adema
    • LaDeana W. Hillier
    • Richard K. Wilson
    ResearchOpen Access
    Nature Communications
    Volume: 8, P: 1-12

  • Clinical and genetic phenotyping of consanguineous family cases of neonatal syndromic diabetes and type 2 diabetes, combined with in-depth functional studies in pluripotent stem cells, reveals a role for genetic variants of ONECUT1 in monogenic and multifactorial diabetes.

    • Anne Philippi
    • Sandra Heller
    • Alexander Kleger
    Research
    Nature Medicine
    Volume: 27, P: 1928-1940

  • Heller et al analyze transcriptomic and epigenetic datasets from human PSCs differentiating into pancreatic progenitors to elucidate the regulatory mechanisms behind pancreatic development. The authors report that the transcription factor ONECUT1 is expressed specifically in pancreatic development and associates with other key TFs (such as FOXA2, GATA6, PDX1) during endocrine specification.

    • Sandra Heller
    • Zhijian Li
    • Ivan G. Costa
    ResearchOpen Access
    Communications Biology
    Volume: 4, P: 1-12