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Showing 1–2 of 2 results
Advanced filters: Author: Ryan Rebernick Clear advanced filters

  • Genome-wide association analysis of triglycerides to high-density lipoprotein cholesterol (TG:HDL-C) ratio within the UK Biobank identifies candidate insulin resistance-associated loci linked to metabolic pathways and insulin biology. A polygenic risk score derived from these results shows an association with multiple cardiometabolic traits.

    • Antonino Oliveri
    • Ryan J Rebernick
    • Elizabeth K. Speliotes
    Research
    Nature Genetics
    Volume: 56, P: 212-221

  • Loss of PP2A activity is often associated with cancer but the underlying mechanism remains unclear. Here, the authors show that decreased methylation of PP2A catalytic C subunit caused by loss of LCMT-1 in prostate cancer abrogates the tumor suppressor activity of PP2A on AR/MED1-dependent gene expression, proposing decreased methyl-PP2A-C as a prognostic marker for prostate cancer progression.

    • Reyaz ur Rasool
    • Caitlin M. O’Connor
    • Irfan A. Asangani
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-24