Synthetic biologists aim to apply well-known principles of gene regulation to build living systems with desired properties. This study has combined microfluidics, single-cell microscopy and computational modelling to develop a bacterial gene oscillator that is fast, robust, persistent and whose frequency can be tuned externally. The combination of experimental and theoretical work reveals a simplified oscillator design without the need for positive feedback.
- Jesse Stricker
- Scott Cookson
- Jeff Hasty
