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A candidate antibody drug for prevention of malaria

Isolation and optimization of antibodies targeting the malaria parasite may offer the potential for immediate protection as a prophylactic intervention to prevent severe disease.

Katherine L. Williams
Steve Guerrero
Daniel E. Emerling
ResearchOpen Access02 Jan 2024
Nature Medicine

Volume: 30, P: 117-129
Crystal structure of a non-neutralizing antibody to the HIV-1 gp41 membrane-proximal external region

Despite recognizing an epitope on HIV-1 gp41 that partially overlaps with those from broadly neutralizing antibodies, mAb 13H11 is non-neutralizing. Now the crystal structure and binding studies of 13H11 Fab with a gp41 peptide reveal why: the antigen assumes a helical structure consistent with the post-fusion conformation of gp41.

Nathan I Nicely
S Moses Dennison
Barton F Haynes
Research14 Nov 2010
Nature Structural & Molecular Biology

Volume: 17, P: 1492-1494
Conformationally selective RNA aptamers allosterically modulate the β₂-adrenoceptor

Evolution of RNA aptamers that act allosterically by recognizing and stabilizing specific conformations, including active, inactive, and ligand-specific conformations of the GPCR β₂-adrenergic receptor, bound to pharmacologically distinct ligands.

Alem W Kahsai
James W Wisler
Robert J Lefkowitz
Research11 Jul 2016
Nature Chemical Biology

Volume: 12, P: 709-716
In vitro and in vivo inhibition of malaria parasite infection by monoclonal antibodies against Plasmodium falciparum circumsporozoite protein (CSP)

Merricka C. Livingstone
Alexis A. Bitzer
Sheetij Dutta
ResearchOpen Access05 Mar 2021
Scientific Reports

Volume: 11, P: 1-15
Subclass and avidity of circumsporozoite protein specific antibodies associate with protection status against malaria infection

Kelly E. Seaton
Rachel L. Spreng
S. Moses Dennison
ResearchOpen Access30 Aug 2021
npj Vaccines

Volume: 6, P: 1-13

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A candidate antibody drug for prevention of malaria

Crystal structure of a non-neutralizing antibody to the HIV-1 gp41 membrane-proximal external region

Conformationally selective RNA aptamers allosterically modulate the β2-adrenoceptor

In vitro and in vivo inhibition of malaria parasite infection by monoclonal antibodies against Plasmodium falciparum circumsporozoite protein (CSP)

Subclass and avidity of circumsporozoite protein specific antibodies associate with protection status against malaria infection

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Conformationally selective RNA aptamers allosterically modulate the β₂-adrenoceptor