Nature Search

High-throughput screening identifies Aurora kinase B as a critical therapeutic target for Merkel cell carcinoma

Merkel cell carcinoma (MCC) is a rare aggressive skin cancer with limited therapeutic options. In this work, the authors identify aurora kinase B (AURKB) as a critical therapeutic target for MCC, supported by tumour shrinkage and increased survival when using the AURKB inhibitor AZD2811 nanoparticle formulation in MCC preclinical models.

Tara Gelb
Khalid A. Garman
Isaac Brownell
ResearchOpen Access12 Feb 2025
Nature Communications

Volume: 16, P: 1-15
Tumor reactive γδ T cells contribute to a complete response to PD-1 blockade in a Merkel cell carcinoma patient

Immune checkpoint blockade cancer therapy has been designed to enable tumor killing by conventional αβ T cells. Here authors show that in a Merkel cell carcinoma patient showing complete response to anti-PD-1 treatment, innate-like γδ T cells that specifically recognize the tumor cells expand, and likely contribute to therapeutic success.

Scott C. Lien
Dalam Ly
Pamela S. Ohashi
ResearchOpen Access06 Feb 2024
Nature Communications

Volume: 15, P: 1-11
Author Correction: Merkel cell polyomavirus activates LSD1-mediated blockade of non-canonical BAF to regulate transformation and tumorigenesis

Donglim Esther Park
Jingwei Cheng
James A. DeCaprio
Amendments and Corrections15 May 2020
Nature Cell Biology

Volume: 22, P: 752
Merkel cell polyomavirus activates LSD1-mediated blockade of non-canonical BAF to regulate transformation and tumorigenesis

Park et al. show that Merkel cell polyomavirus upregulates LSD1 activity to repress differentiation genes that can be activated by non-canonical BAF, thereby modulating transformation and tumorigenesis in Merkel cell carcinoma.

Donglim Esther Park
Jingwei Cheng
James A. DeCaprio
Research13 Apr 2020
Nature Cell Biology

Volume: 22, P: 603-615
Management and outcomes of periorbital Merkel cell carcinoma: a tertiary eye centre experience

Li Teng Kok
Allan Z. Nghiem
Clare S. Daniel
Research04 Feb 2025
Eye

Volume: 39, P: 1011-1014
Neoadjuvant polychemotherapy in locally advanced Merkel cell carcinoma

This case study discusses two patients with locally advanced Merkel cell carcinoma. The authors describe how neoadjuvant polychemotherapy was used to treat these patients allowing curative-intent surgery plus radiotherapy.

Thomas Jouary
Nathalie Lalanne
Alain Taieb
Reviews01 Sept 2009
Nature Reviews Clinical Oncology

Volume: 6, P: 544-548
Diagnostic accuracy of a panel of immunohistochemical and molecular markers to distinguish Merkel cell carcinoma from other neuroendocrine carcinomas

Thibault Kervarrec
Anne Tallet
Serge Guyétant
Research22 Oct 2018
Modern Pathology

Volume: 32, P: 499-510
Morphologic and immunophenotypical features distinguishing Merkel cell polyomavirus-positive and negative Merkel cell carcinoma

Thibault Kervarrec
Anne Tallet
Serge Guyétant
Research14 Jun 2019
Modern Pathology

Volume: 32, P: 1605-1616
Merkel cell carcinoma

Merkel cell carcinoma (MCC) is a rare, highly metastatic skin cancer. MCC pathogenesis is associated with either the presence of Merkel cell polyomavirus or chronic exposure to ultraviolet light, which can cause a characteristic pattern of multiple DNA mutations.

Jürgen C. Becker
Andreas Stang
Paul Nghiem
Reviews26 Oct 2017
Nature Reviews Disease Primers

Volume: 3, P: 1-17
The biology and treatment of Merkel cell carcinoma: current understanding and research priorities

Merkel cell carcinoma (MCC) is a rare and aggressive form of nonmelanoma skin cancer. The availability of immune checkpoint inhibition has improved the outcomes of a subset of patients with MCC, although many unmet needs continue to exist. In this Consensus Statement, the authors summarize developments in our understanding of MCC while also providing consensus recommendations for future research.

Paul W. Harms
Kelly L. Harms
Isaac Brownell
ReviewsOpen Access04 Oct 2018
Nature Reviews Clinical Oncology

Volume: 15, P: 763-776
Clinical significance of the expression of FOXP3 and TIGIT in Merkel cell carcinoma

Takeshi Iwasaki
Kazuhiko Hayashi
Yoshinao Oda
ResearchOpen Access12 Aug 2023
Scientific Reports

Volume: 13, P: 1-11
Prokineticins and Merkel cell polyomavirus infection in Merkel cell carcinoma

S Lauttia
H Sihto
H Joensuu
ResearchOpen Access04 Feb 2014
British Journal of Cancer

Volume: 110, P: 1446-1455
Detection of Merkel cell virus and correlation with histologic presence of Merkel cell carcinoma in sentinel lymph nodes

M Loyo
J Schussel
J M Taube
ResearchOpen Access13 Mar 2012
British Journal of Cancer

Volume: 106, P: 1314-1319
Mutation analysis of P73 and TP53 in Merkel cell carcinoma

M Van Gele
M Kaghad
F Speleman
ResearchOpen Access20 Jan 2000
British Journal of Cancer

Volume: 82, P: 823-826
Histological pattern of Merkel cell carcinoma sentinel lymph node metastasis improves stratification of Stage III patients

Jennifer S Ko
Victor G Prieto
Steven D Billings
Research06 Nov 2015
Modern Pathology

Volume: 29, P: 122-130
Vascular invasion is an early event in pathogenesis of Merkel cell carcinoma

Heli M Kukko
Virve S K Koljonen
Tom O Böhling
Research14 May 2010
Modern Pathology

Volume: 23, P: 1151-1156
Are there multiple cells of origin of Merkel cell carcinoma?

J. C. Sunshine
N. S. Jahchan
J. Choi
Reviews11 Jan 2018
Oncogene

Volume: 37, P: 1409-1416
Erratum: Merkel cell polyomavirus small T antigen induces genome instability by E3 ubiquitin ligase targeting

H J Kwun
J A Wendzicki
Y Chang
Amendments and CorrectionsOpen Access09 Oct 2017
Oncogene

Volume: 36, P: 6838
Merkel cell polyomavirus and non-small cell lung cancer

M Shuda
H Feng
Y Chang
CorrespondenceOpen Access04 Jun 2013
British Journal of Cancer

Volume: 108, P: 2623
Merkel cell polyomavirus small T antigen induces genome instability by E3 ubiquitin ligase targeting

H J Kwun
J A Wendzicki
Y Chang
ResearchOpen Access28 Aug 2017
Oncogene

Volume: 36, P: 6784-6792
Merkel cell carcinoma expresses vasculogenic mimicry: demonstration in patients and experimental manipulation in xenografts

Cecilia Lezcano
Sonja Kleffel
George F Murphy
Research11 Aug 2014
Laboratory Investigation

Volume: 94, P: 1092-1102
Herpesviruses mimic zygotic genome activation to promote viral replication

Neugebauer et al. show activation of the usually silenced embryonic factor DUX4 by herpesviruses in vitro and in patients, and demonstrate that depletion of DUX4 by nanobody degraders abrogates viral replication.

Eva Neugebauer
Stephanie Walter
Florian Full
ResearchOpen Access16 Jan 2025
Nature Communications

Volume: 16, P: 1-15
Sensory Schwann cells set perceptual thresholds for touch and selectively regulate mechanical nociception

Schwann cells associated with most sensory receptors in the skin actively participate in the transduction of mechanical stimuli. Here the authors show that silencing these sensory Schwann cells is sufficient to reduce touch perception and can inhibit mechanical pain in mice.

Julia Ojeda-Alonso
Laura Calvo-Enrique
Gary R. Lewin
ResearchOpen Access06 Feb 2024
Nature Communications

Volume: 15, P: 1-14
The rapidly evolving paradigm of neoadjuvant immunotherapy across cancer types

In this Review, Chalabi and colleagues summarize the current clinical landscape of neoadjuvant immunotherapy in solid tumors.

Gil Awada
Tina Cascone
Myriam Chalabi
Reviews24 Jun 2025
Nature Cancer

Volume: 6, P: 967-987
Optimizing the heat transfer characteristics of MWCNTs and TiO₂ water-based nanofluids through a novel designed pilot-scale setup

Reza Javadpour
Saeed Zeinali Heris
Seyed Borhan Mousavi
ResearchOpen Access07 Sept 2022
Scientific Reports

Volume: 12, P: 1-23
Whole genome sequencing improves tissue-of-origin diagnosis and treatment options for cancer of unknown primary

Patients with metastatic cancers of unknown primary (CUP) are currently unable to gain access to drugs through standard of care or clinical trials. Here, the authors perform whole-genome and transcriptome sequencing (WGTS) on 72 patients with CUP and demonstrate the feasibility of using WGTS to determine the specific cancer types of CUP, thereby clinically benefiting patients with CUP.

Richard J. Rebello
Atara Posner
Richard W. Tothill
ResearchOpen Access20 May 2025
Nature Communications

Volume: 16, P: 1-15
Long-term safety of lentiviral or gammaretroviral gene-modified T cell therapies

In an analysis of long-term safety events in 783 patients treated with T cell therapy in 38 trials, 2.3% of patients developed second primary malignancies, and vector integration analyses revealed no pathological insertions.

Julie K. Jadlowsky
Elizabeth O. Hexner
Joseph A. Fraietta
Research20 Jan 2025
Nature Medicine

Volume: 31, P: 1134-1144
Piezo2 is the major transducer of mechanical forces for touch sensation in mice

Mice lacking the mechanically activated ion channel Piezo2 in both sensory neurons and Merkel cells are almost totally incapable of light-touch sensation while other somatosensory functions, such as mechanical nociception, remain intact, implying that other mechanically activated ion channels must now be identified to account for painful touch sensation.

Sanjeev S. Ranade
Seung-Hyun Woo
Ardem Patapoutian
Research03 Dec 2014
Nature

Volume: 516, P: 121-125
Hair-bearing human skin generated entirely from pluripotent stem cells

Skin organoids generated in vitro from human pluripotent stem cells form complex, multilayered skin tissue with hair follicles, sebaceous glands and neural circuitry, and integrate with endogenous skin when grafted onto immunocompromised mice.

Jiyoon Lee
Cyrus C. Rabbani
Karl R. Koehler
Research03 Jun 2020
Nature

Volume: 582, P: 399-404
Blockchain enhanced distributed denial of service detection in IoT using deep learning and evolutionary computation

V. V. S. H. Prasad
Swathi Sowmya Bavirthi
Mohamad Khairi Ishak
ResearchOpen Access02 Jul 2025
Scientific Reports

Volume: 15, P: 1-24
Enabling next-generation engineered TCR-T therapies based on high-throughput TCR discovery from diagnostic tumor biopsies

Kuilman et al. established a functional genetic screening platform for the efficient identification of tumor-specific TCRs. It is compatible with routine diagnostic tumor biopsies and can be applied in fully individualized TCR-T cell therapy.

Thomas Kuilman
Deborah S. Schrikkema
Gavin M. Bendle
ResearchOpen Access14 Jan 2025
Nature Communications

Volume: 16, P: 1-14
Acquired cancer resistance to combination immunotherapy from transcriptional loss of class I HLA

Acquired resistance is a major problem in cancer immunotherapy. Here the authors report a study of two patients with Merkel cell carcinoma under immunotherapy treatment who develop resistance after deep responses for >1 year and identified a novel mechanism of acquired, gene-specific transcriptional suppression of HLAs.

K. G. Paulson
V. Voillet
A. G. Chapuis
ResearchOpen Access24 Sept 2018
Nature Communications

Volume: 9, P: 1-10
A cutaneous mechanoneural interface for neuroprosthetic feedback

A neuroprosthetic interface comprising a muscle actuator coupled to a natively pedicled skin flap in a cuff-like architecture elicits graded contact and vibratory afferent signals analogous to those elicited by mechanical stimulation of intact skin.

Shriya S. Srinivasan
Hugh M. Herr
Research01 Feb 2021
Nature Biomedical Engineering

Volume: 6, P: 731-740
Autogene cevumeran with or without atezolizumab in advanced solid tumors: a phase 1 trial

In this phase 1 trial, patients with locally advanced or metastatic solid tumors were treated with the individualized mRNA neoantigen-specific immunotherapy (iNeST) autogene cevumeran alone or in combination with the anti-PD-L1 agent atezolizumab, showing long-lasting neoantigen-specific immune responses and preliminary clinical activity, supporting further development of this therapeutic approach.

Juanita Lopez
Thomas Powles
D. Ross Camidge
ResearchOpen Access06 Jan 2025
Nature Medicine

Volume: 31, P: 152-164
The structure of liquid carbon elucidated by in situ X-ray diffraction

A precise structure measurement of liquid carbon at pressures of around 1 million atmospheres obtained by in situ X-ray diffraction at an X-ray free-electron laser shows a complex fluid with transient bonding and approximately four nearest neighbours on average.

D. Kraus
J. Rips
M. I. McMahon
ResearchOpen Access21 May 2025
Nature

Volume: 642, P: 351-355
Parochial energy policy

The German decision to abandon its nuclear energy ambitions was driven by local politics not the wider emissions agenda.

David Adam
Comments & Opinion27 Jul 2011
Nature Climate Change

Volume: 1, P: 230-232
A cornucopia of human polyomaviruses

In recent years, nine new human polyomaviruses have been discovered, including Merkel cell polyomavirus, which has been linked to Merkel cell carcinoma, a lethal skin cell cancer. DeCaprio and Garcea compare and contrast these new human viruses and discuss how they might interact with their human host.

James A. DeCaprio
Robert L. Garcea
Reviews11 Mar 2013
Nature Reviews Microbiology

Volume: 11, P: 264-276
A vagal reflex evoked by airway closure

A specific neural reflex of the vagus nerve is identified that induces gasping in response to airway closure.

Michael S. Schappe
Philip A. Brinn
Stephen D. Liberles
ResearchOpen Access06 Mar 2024
Nature

Volume: 627, P: 830-838
Bioinspired adaptable multiplanar mechano-vibrotactile haptic system

Challenges persist in haptic device development due to the complex nature of touch. The authors propose a Bioinspired Adaptable Multiplanar Haptic system providing multipoint and variable intensity pulse stimuli (0-130 Hz) across multiple fingertip areas, enabling deeper study of touch skin sensors.

Sara-Adela Abad
Nicolas Herzig
Helge Wurdemann
ResearchOpen Access11 Sept 2024
Nature Communications

Volume: 15, P: 1-12
A survey of pathogenic involvement in non-communicable human diseases

Lape et al. use electronic health records and a discovery-replication cohort study design to investigate links between common pathogens and non-communicable diseases. Evidence is found for over 200 associations, such as a role for human cytomegalovirus in ulcerative colitis.

Michael Lape
Daniel Schnell
Matthew T. Weirauch
ResearchOpen Access20 Jun 2025
Communications Medicine

Volume: 5, P: 1-15
Lineage-specific canonical and non-canonical activity of EZH2 in advanced prostate cancer subtypes

Enhancer of zeste homolog 2 (EZH2) has been implicated as a driver of disease progression and resistance to hormonal therapies. Here, the authors focus on EZH2 in two subtypes of advanced prostate cancer and report how it modulates the bivalent genes thereby leading to forward differentiation after being targeted in neuroendocrine prostate cancer.

Varadha Balaji Venkadakrishnan
Adam G. Presser
Himisha Beltran
ResearchOpen Access08 Aug 2024
Nature Communications

Volume: 15, P: 1-15
Real-time functional proteomics enhances therapeutic targeting in precision oncology molecular tumor boards

Allison L. Hunt
Jamie Randall
Thomas P. Conrads
ResearchOpen Access15 Apr 2025
npj Precision Oncology

Volume: 9, P: 1-12
Liquid biopsy epigenomic profiling for cancer subtyping

In a large multi-cancer cohort, a single liquid biopsy assay enables the detection of four epigenomic modifications, allowing the monitoring of expression of potential drug targets and resistance genes.

Sylvan C. Baca
Ji-Heui Seo
Matthew L. Freedman
ResearchOpen Access21 Oct 2023
Nature Medicine

Volume: 29, P: 2737-2741
Melatonin induces a stimulatory action on the scrotal skin components of Soay ram in the non-breeding season

Fatma El-Zahraa A. Mustafa
Fatma M. Abdel-maksoud
Doaa M. Mokhtar
ResearchOpen Access23 Jun 2020
Scientific Reports

Volume: 10, P: 1-15
Subtype heterogeneity and epigenetic convergence in neuroendocrine prostate cancer

Neuroendocrine carcinomas (NECs) arise from different anatomic sites, but have similar histological and clinical features. Here, the authors show that the epigenetic landscape of a range of NECs converges towards a common epigenetic state, while distinct subtypes occur within neuroendocrine prostate cancer contributing to intratumor heterogeneity in clinical samples.

Paloma Cejas
Yingtian Xie
Henry W. Long
ResearchOpen Access01 Oct 2021
Nature Communications

Volume: 12, P: 1-11
Wild and domesticated animal abundance is associated with greater late-Holocene alpine plant diversity

The role of wild and domesticated animals on alpine ecosystems is unclear. Here, the authors use sedaDNA from 14 European alpine lakes to demonstrate a positive association between wild and domesticated animal and plant diversity through the past 14 thousand years.

Sandra Garcés-Pastor
Peter D. Heintzman
Inger Greve Alsos
ResearchOpen Access25 Apr 2025
Nature Communications

Volume: 16, P: 1-11
Impurities in Preparations of Acetabularia Chloroplasts

R. G. S. BIDWELL
Research19 May 1972
Nature

Volume: 237, P: 169
Cytokeratin 7 and Cytokeratin 20 Expression in Epithelial Neoplasms: A Survey of 435 Cases

Peiguo Chu
Emerald Wu
Lawrence M Weiss
Research01 Sept 2000
Modern Pathology

Volume: 13, P: 962-972
Thyroid Transcription Factor-1 Is Expressed in Extrapulmonary Small Cell Carcinomas but Not in Other Extrapulmonary Neuroendocrine Tumors

S Nicholas Agoff
Laura W Lamps
Andrew L Folpe
Research01 Mar 2000
Modern Pathology

Volume: 13, P: 238-242
A breakpoint map of recurrent chromosomal rearrangements in human neoplasia

Felix Mitelman
Fredrik Mertens
Bertil Johansson
Research01 Apr 1997
Nature Genetics

Volume: 15, P: 417-474

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