Nature Search

Enhanced green fluorescent protein fusion proteins of herpes simplex virus type 1 thymidine kinase and cytochrome P450 4B1: Applications for prodrug-activating gene therapy

Sabine Steffens
Susanne Frank
Christof M Kramm
Research15 Jun 2000
Cancer Gene Therapy

Volume: 7, P: 806-812
GPR55 in B cells limits atherosclerosis development and regulates plasma cell maturation

Using various mouse models, human plaque data and isolated B cells combined with state-of-the-art imaging and transcriptomic analysis, the authors show that the G-protein-coupled orphan receptor GPR55 regulates B cell activation and plasma cell differentiation during hypercholesterolemia, which crucially affects atherosclerosis.

Raquel Guillamat-Prats
Daniel Hering
Sabine Steffens
ResearchOpen Access11 Nov 2022
Nature Cardiovascular Research

Volume: 1, P: 1056-1071
Erratum: Low dose oral cannabinoid therapy reduces progression of atherosclerosis in mice

Sabine Steffens
Niels R. Veillard
François Mach
Amendments and Corrections26 May 2005
Nature

Volume: 435, P: 528
Correction: Corrigendum: Endothelial Dicer promotes atherosclerosis and vascular inflammation by miRNA-103-mediated suppression of KLF4

Petra Hartmann
Zhe Zhou
Andreas Schober
Amendments and CorrectionsOpen Access07 Jun 2016
Nature Communications

Volume: 7, P: 1
Deep intravital brain tumor imaging enabled by tailored three-photon microscopy and analysis

Observation of glioblastoma invasion in subcortical brain regions is challenging. Here the authors develop a Deep3P workflow to enable longitudinal deep imaging of glioblastoma and its microenvironment by combining three-photon microscopy and deep learning-based analysis, unraveling the invasion routes of these tumor cells into and within the white matter.

Marc Cicero Schubert
Stella Judith Soyka
Varun Venkataramani
ResearchOpen Access10 Sept 2024
Nature Communications

Volume: 15, P: 1-21
Low dose oral cannabinoid therapy reduces progression of atherosclerosis in mice

Sabine Steffens
Niels R. Veillard
François Mach
Research07 Apr 2005
Nature

Volume: 434, P: 782-786
Cell-specific and divergent roles of the CD40L-CD40 axis in atherosclerotic vascular disease

Previous studies have shown that the CD40L-CD40 signaling axis plays a role in atherosclerosis. Here the authors investigate the cell-specific functions of the most relevant CD40L-expressing cell types in atherosclerosis. Deficiency of T cell-derived CD40L reduces and stabilizes plaques through impaired Th1 polarization while platelet-derived CD40L ameliorates atherothrombosis.

Michael Lacy
Christina Bürger
Esther Lutgens
ResearchOpen Access18 Jun 2021
Nature Communications

Volume: 12, P: 1-12
Pairing of single-cell RNA analysis and T cell antigen receptor profiling indicates breakdown of T cell tolerance checkpoints in atherosclerosis

Wang et al. profiled T cells in atherosclerotic plaques, artery tertiary lymphoid organs, and lymph nodes in mice with advanced atherosclerosis by single-cell RNA sequencing paired with T cell antigen receptor sequencing and observed complex patterns of deteriorating peripheral T cell tolerance. Signs of CD8⁺ tolerance dysfunction were found also in human plaques transcriptomic data, indicating that atherosclerosis can be considered as a bona fide T cell autoimmune disease.

Zhihua Wang
Xi Zhang
Changjun Yin
ResearchOpen Access23 Feb 2023
Nature Cardiovascular Research

Volume: 2, P: 290-306
Endothelial Dicer promotes atherosclerosis and vascular inflammation by miRNA-103-mediated suppression of KLF4

The RNAse III endonuclease Dicer is crucial for processing of pre-miRNAs in health and disease. Here the authors show that endothelial Dicer promotes atherosclerosis by increasing miR-103 levels leading to suppression of the anti-inflammatory transcription factor KLF4, thus suggesting a novel approach to treat this disease.

Petra Hartmann
Zhe Zhou
Andreas Schober
ResearchOpen Access03 Feb 2016
Nature Communications

Volume: 7, P: 1-16
Neuroimmune cardiovascular interfaces control atherosclerosis

The peripheral nervous system uses neuroimmune cardiovascular interfaces to assemble a structural artery–brain circuit, and therapeutic intervention in the artery–brain circuit attenuates atherosclerosis.

Sarajo K. Mohanta
Li Peng
Andreas J. R. Habenicht
Research27 Apr 2022
Nature

Volume: 605, P: 152-159
Psychiatric genome-wide association study analyses implicate neuronal, immune and histone pathways

Better analytical methods are needed to extract biological meaning from genome-wide association studies (GWAS) of psychiatric disorders. Here the authors take GWAS data from over 60,000 subjects, including patients with schizophrenia, bipolar disorder and major depression, and identify common etiological pathways shared amongst them.

Colm O'Dushlaine
Lizzy Rossin
Gerome Breen
Research19 Jan 2015
Nature Neuroscience

Volume: 18, P: 199-209
ApoE attenuates unresolvable inflammation by complex formation with activated C1q

ApoE is a direct checkpoint inhibitor of unresolvable inflammation in neurodegenerative and cardiovascular diseases

Changjun Yin
Susanne Ackermann
Andreas J. R. Habenicht
Research28 Jan 2019
Nature Medicine

Volume: 25, P: 496-506
Drug Insight: immunomodulatory effects of statins—potential benefits for renal patients?

The therapeutic potential of statins might extend beyond lipid lowering in cardiovascular disease. Experimental and clinical data to support this assertion are assessed here by authors from the University Hospital of Geneva, with an emphasis on the capacity of drugs of this class to modulate immune processes which affect the kidney during progression of chronic renal disease and transplantation.

Sabine Steffens
François Mach
Reviews01 Jul 2006
Nature Clinical Practice Nephrology

Volume: 2, P: 378-387
Publisher Correction: ApoE attenuates unresolvable inflammation by complex formation with activated C1q

Changjun Yin
Susanne Ackermann
Andreas J. R. Habenicht
Amendments and Corrections04 Feb 2019
Nature Medicine

Volume: 25, P: 529
Cardiovascular effects of marijuana and synthetic cannabinoids: the good, the bad, and the ugly

Over the past decade, marijuana has been legalized for medicinal purposes or recreational use in many countries, and the potency of marijuana and synthetic cannabinoids has substantially increased. In this Review, Pacher and colleagues summarize the role of the endocannabinoid system in cardiovascular health and disease, and critically discuss the beneficial and detrimental cardiovascular effects of marijuana and synthetic cannabinoid use.

Pal Pacher
Sabine Steffens
George Kunos
Reviews14 Sept 2017
Nature Reviews Cardiology

Volume: 15, P: 151-166
Neutrophils as protagonists and targets in chronic inflammation

Neutrophils are rapidly recruited to tissues in response to injury or infection, and they have mainly been studied in the context of acute inflammation. However, neutrophils can also be important contributors to chronic tissue inflammation. This Review discusses neutrophil function in the context of chronic inflammation and considers the potential of targeting these cells in chronic diseases.

Oliver Soehnlein
Sabine Steffens
Christian Weber
Reviews13 Mar 2017
Nature Reviews Immunology

Volume: 17, P: 248-261
Genetic relationship between five psychiatric disorders estimated from genome-wide SNPs

Naomi Wray and colleagues report an analysis of genome-wide association data sets from the Psychiatric Genomics Consortium for five psychiatric disorders. They find that common variation explains 17–29% of the variance in liability and provide further support for a shared genetic etiology for these related psychiatric disorders.

S Hong Lee
Stephan Ripke
Naomi R Wray
Research11 Aug 2013
Nature Genetics

Volume: 45, P: 984-994
Haematopoietic and cardiac GPR55 synchronize post-myocardial infarction remodelling

Sarah-Lena Puhl
Michael Hilby
Sabine Steffens
ResearchOpen Access13 Jul 2021
Scientific Reports

Volume: 11, P: 1-14
Strong spin resonance mode associated with suppression of soft magnetic ordering in hole-doped Ba_1-xNa_xFe₂As₂

Florian Waßer
Jitae T. Park
Markus Braden
ResearchOpen Access03 Dec 2019
npj Quantum Materials

Volume: 4, P: 1-9
A Neuroblastoma-Selective Suicide Gene Therapy Approach Using the Tyrosine Hydroxylase Promoter

Sabine Steffens
Anke Sandquist
Christof M Kramm
Research01 Aug 2004
Pediatric Research

Volume: 56, P: 268-277
Differential cytotoxicity and bystander effect of the rabbit cytochrome P450 4B1 enzyme gene by two different prodrugs: Implications for pharmacogene therapy

Susanne Frank
Sabine Steffens
Christof M Kramm
Research18 Feb 2002
Cancer Gene Therapy

Volume: 9, P: 178-188
Mechanisms of thymidine kinase/ganciclovir and cytosine deaminase/ 5-fluorocytosine suicide gene therapy-induced cell death in glioma cells

Ute Fischer
Sabine Steffens
Christof M Kramm
Research13 Dec 2004
Oncogene

Volume: 24, P: 1231-1243

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