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Showing 1–6 of 6 results
Advanced filters: Author: Sam Horrell Clear advanced filters

  • Structural biology plays a crucial role in the fight against COVID-19, permitting us to ‘see’ and understand SARS-CoV-2. However, the macromolecular structures of SARS-CoV-2 proteins that were solved with great speed and urgency can contain errors that may hinder drug design. The Coronavirus Structural Task Force has been working behind the scenes to evaluate and improve these structures, making the results freely available at https://insidecorona.net/.

    • Tristan I. Croll
    • Kay Diederichs
    • Andrea Thorn
    Comments & Opinion
    Nature Structural & Molecular Biology
    Volume: 28, P: 404-408

  • Multi-crystal methods such as serial crystallography can provide a complete 3D structure of the target material before radiation damage becomes significant, but the methods are challenging for small molecule crystals with small unit cells, where very few reflections are recorded in a single data image. Here, the authors present a small-rotative fixed-target serial synchrotron crystallography (SR-FT-SSX) methodology, in which rotation of the serial target through a small diffraction angle \((\varphi )\) at each crystal delivers high-quality data, facilitating ab initio unit cell determination and atomic-scale structure solution.

    • Sam G. Lewis
    • Ben A. Coulson
    • Lauren E. Hatcher
    ResearchOpen Access
    Communications Chemistry
    Volume: 7, P: 1-7

  • Understanding the stability of the eye lens protein human gamma-D crystallin (HGD) is essential to developing tools to prevent the formation of cataracts, however, structural investigations of the response of HGD to ultraviolet radiation are lacking. Here, the authors use continuous illumination serial crystallography to directly probe the mechanism of R36S HGD in response to ultraviolet radiation damage.

    • Jake A. Hill
    • Yvonne Nyathi
    • Briony A. Yorke
    ResearchOpen Access
    Communications Chemistry
    Volume: 7, P: 1-8