Nature Search

Author Correction: Disruption of neural periodicity predicts clinical response after deep brain stimulation for obsessive-compulsive disorder

Nicole R. Provenza
Sandesh Reddy
Sameer A. Sheth
Amendments and CorrectionsOpen Access26 Mar 2025
Nature Medicine

Volume: 31, P: 1716
Endocisternal interfaces for minimally invasive neural stimulation and recording of the brain and spinal cord

Endocisternal neural interfaces with wireless and magnetoelectrically powered electronics that approach brain and spinal cord targets through spaces filled with cerebrospinal fluid can perform recording and stimulation functions and devices can be removed after chronic implantation.

Joshua C. Chen
Abdeali Dhuliyawalla
Peter Kan
Research11 Nov 2024
Nature Biomedical Engineering

Volume: 9, P: 896-904
Author Correction: Beta activity in human anterior cingulate cortex mediates reward biases

Jiayang Xiao
Joshua A. Adkinson
Sameer A. Sheth
Amendments and CorrectionsOpen Access25 Jun 2025
Nature Communications

Volume: 16, P: 1
Author Correction: Endocisternal interfaces for minimally invasive neural stimulation and recording of the brain and spinal cord

Joshua C. Chen
Abdeali Dhuliyawalla
Peter Kan
Amendments and Corrections27 Jan 2025
Nature Biomedical Engineering

Volume: 9, P: 985
Disruption of neural periodicity predicts clinical response after deep brain stimulation for obsessive-compulsive disorder

Machine learning classifiers generated using chronic neural measurements in individuals with obsessive-compulsive disorder accurately predicted clinical status and deep brain stimulation response.

Nicole R. Provenza
Sandesh Reddy
Sameer A. Sheth
ResearchOpen Access12 Jul 2024
Nature Medicine

Volume: 30, P: 3004-3014
A population-based analysis of the molecular landscape of glioma in adolescents and young adults reveals insights into gliomagenesis

Bennett et al. conducted a population-based study in adolescents and young adults with gliomas, revealing the specific molecular alterations and identifying potential subclassifications and targets.

Julie Bennett
Adrian B. Levine
Cynthia Hawkins
Research07 May 2025
Nature Cancer

Volume: 6, P: 1102-1119
Beta activity in human anterior cingulate cortex mediates reward biases

Understanding how rewards can override our initial sensory judgments and influence decision-making is crucial. Here the authors show that the anterior cingulate cortex plays an important role in mediating reward biasing.

Jiayang Xiao
Joshua A. Adkinson
Sameer A. Sheth
ResearchOpen Access15 Jul 2024
Nature Communications

Volume: 15, P: 1-13
Widespread temporal coding of cognitive control in the human prefrontal cortex

Using intracranial recordings in humans, the authors found decision conflict-related effects on firing rate in the dorsal anterior cingulate cortex (dACC), on spike-phase coupling in the dACC, and on spike-field coherence in the dorsolateral prefrontal cortex.

Elliot H. Smith
Guillermo Horga
Sameer A. Sheth
Research30 Sept 2019
Nature Neuroscience

Volume: 22, P: 1883-1891
An application-based taxonomy for brain–computer interfaces

Naming brain–computer interfaces according to their intended application will assist stakeholders in the evaluation of the benefits and risks of neurotechnologies.

Jacob T. Robinson
Sumner L. Norman
Chong Xie
Comments & Opinion23 Dec 2024
Nature Biomedical Engineering

Volume: 9, P: 789-791
Human dorsal anterior cingulate cortex neurons mediate ongoing behavioural adaptation

Functional imaging, single-cell recording and targeted surgical lesions were used in human patients undergoing cingulotomy to show that the dorsal anterior cingulate cortex provides a continuously updated prediction of expected cognitive demand.

Sameer A. Sheth
Matthew K. Mian
Emad N. Eskandar
Research24 Jun 2012
Nature

Volume: 488, P: 218-221
Epigenetic activation of a RAS/MYC axis in H3.3K27M-driven cancer

Histone H3 at lysine 27 (H3K27M) is often mutated in cancer but its role in tumour initiation is unclear. Here, the authors generated a transgenic model expressing H3.3K27M from the Fabp7 gene promoter, demonstrating that H3.3K27M can initiate diverse tumorigesis on its own, acting through a RAS/MYC transcriptomic programme.

Sanja Pajovic
Robert Siddaway
Cynthia Hawkins
ResearchOpen Access04 Dec 2020
Nature Communications

Volume: 11, P: 1-16
Distinct cortical systems reinstate the content and context of episodic memories

People can search for memories based on their content or context, defined as when and where they were formed. Here, the authors use direct brain recordings to provide evidence in line with the idea that separable neural systems retrieve these two types of information and predict whether recall is organized by time or content.

James E. Kragel
Youssef Ezzyat
Michael J. Kahana
ResearchOpen Access21 Jul 2021
Nature Communications

Volume: 12, P: 1-10
Functionally distinct high and low theta oscillations in the human hippocampus

We show that the human hippocampus exhibits two distinct theta oscillations during spatial navigation with the faster oscillation in posterior regions showing movement modulation. This result suggests a distinct feature of the human hippocampus compared to rodents, which generally show a single 8 Hz rhythm.

Abhinav Goyal
Jonathan Miller
Joshua Jacobs
ResearchOpen Access18 May 2020
Nature Communications

Volume: 11, P: 1-10
Memory retrieval modulates spatial tuning of single neurons in the human entorhinal cortex

Qasim et al. describe neurons in the human entorhinal cortex that activate near the locations in space that a person is cued to recall during a memory task. These results show one way in which the cognitive map shifts according to memory demands.

Salman E. Qasim
Jonathan Miller
Joshua Jacobs
Research11 Nov 2019
Nature Neuroscience

Volume: 22, P: 2078-2086
Long-term ecological assessment of intracranial electrophysiology synchronized to behavioral markers in obsessive-compulsive disorder

The identification of candidate neural biomarkers of obsessive-compulsive disorder symptom intensity in ecologically valid environments.

Nicole R. Provenza
Sameer A. Sheth
David A. Borton
Research09 Dec 2021
Nature Medicine

Volume: 27, P: 2154-2164
Computational sensitivity evaluation of ultrasound neuromodulation resolution to brain tissue sound speed with robust beamforming

Boqiang Fan
Wayne Goodman
Behnaam Aazhang
ResearchOpen Access02 Apr 2025
Scientific Reports

Volume: 15, P: 1-13
Challenges and opportunities of acquiring cortical recordings for chronic adaptive deep brain stimulation

This Perspective argues that the unavailability of cortical electrodes for chronic use may stall research on adaptive deep brain stimulation for treating psychiatric conditions and that this problem can be addressed via public–private partnerships.

Jeffrey Herron
Aura Kullmann
Alik S. Widge
Reviews27 Dec 2024
Nature Biomedical Engineering

Volume: 9, P: 606-617
Lateralized hippocampal oscillations underlie distinct aspects of human spatial memory and navigation

Theta oscillations are implicated in memory formation. Here, the authors show that low-theta oscillations in the hippocampus are differentially modulated between each hemisphere, with oscillations in the left increasing when successfully learning object–___location pairs and in the right during spatial navigation.

Jonathan Miller
Andrew J. Watrous
Joshua Jacobs
ResearchOpen Access21 Jun 2018
Nature Communications

Volume: 9, P: 1-12
Deep brain stimulation for obsessive–compulsive disorder: a crisis of access

Deep brain stimulation is an effective treatment for obsessive–compulsive disorder but is rarely used. Action is needed by psychologists, psychiatrists and insurers so that patients with otherwise intractable cases can receive this therapy to improve their mental health.

Veerle Visser-Vandewalle
Pablo Andrade
Michael S. Okun
Comments & Opinion15 Jul 2022
Nature Medicine

Volume: 28, P: 1529-1532
Aperiodic spectral slope tracks the effects of brain state on saliency responses in the human auditory cortex

Madaline Mocchi
Eleonora Bartoli
Kelly Bijanki
ResearchOpen Access28 Dec 2024
Scientific Reports

Volume: 14, P: 1-14
Using high-frequency oscillations from brief intraoperative neural recordings to predict the seizure onset zone

Fazli Besheli et al. identify intraoperative high frequency oscillations (HFOs) using noise-resilient computational intelligence to effectively localize seizure-generating brain regions. Epileptogenic zones are identified from brief intraoperative neural recordings.

Behrang Fazli Besheli
Zhiyi Sha
Nuri F. Ince
ResearchOpen Access25 Nov 2024
Communications Medicine

Volume: 4, P: 1-13
Cost-effectiveness and threshold analysis of deep brain stimulation vs. treatment-as-usual for treatment-resistant depression

Katherine E. Kabotyanski
Ricardo A. Najera
Sameer A. Sheth
ReviewsOpen Access07 Jun 2024
Translational Psychiatry

Volume: 14, P: 1-14
Benchmarking signal quality and spatiotemporal distribution of interictal spikes in prolonged human iEEG recordings using CorTec wireless brain interchange

Amir Hossein Ayyoubi
Behrang Fazli Besheli
Nuri F. Ince
ResearchOpen Access08 Feb 2024
Scientific Reports

Volume: 14, P: 1-14
Computational modeling and minimization of unintended neuronal excitation in a LIFU stimulation

Boqiang Fan
Wayne Goodman
Behnaam Aazhang
ResearchOpen Access17 Aug 2023
Scientific Reports

Volume: 13, P: 1-11
Connectomic approaches to deep brain stimulation for OCD

Sameer A. Sheth
Wayne Goodman
Research Highlights29 Nov 2021
Neuropsychopharmacology

Volume: 47, P: 801-802
Studying task-related activity of individual neurons in the human brain

Shaun R Patel
Sameer A Sheth
Emad N Eskandar
Protocols18 Apr 2013
Nature Protocols

Volume: 8, P: 949-957
Electroceutically induced subthalamic high-frequency oscillations and evoked compound activity may explain the mechanism of therapeutic stimulation in Parkinson’s disease

Ozturk et al investigate the modulations in local field potentials induced by electrical stimulation of the subthalamic nucleus (STN) at therapeutic and nontherapeutic frequencies in Parkinson’s disease (PD) patients undergoing DBS surgery. They find evidence to suggest that high-frequency STN-DBS tunes the neural oscillations to their healthy/treated state, similar to pharmacological treatment and thus could serve to recalibrate the dysfunctional circuitry generating PD symptoms.

Musa Ozturk
Ashwin Viswanathan
Nuri F. Ince
ResearchOpen Access23 Mar 2021
Communications Biology

Volume: 4, P: 1-14
Reward uncertainty asymmetrically affects information transmission within the monkey fronto-parietal network

Bahareh Taghizadeh and Nicholas Foley et al. show that individual neuronal responses, population spiking activity, and local field potential oscillations encode the variance of expected rewards independent of their value. They also demonstrate that reward uncertainty asymmetrically affects neuronal transmission within the monkey fronto-parietal network.

Bahareh Taghizadeh
Nicholas C. Foley
Jacqueline Gottlieb
ResearchOpen Access21 Oct 2020
Communications Biology

Volume: 3, P: 1-11
Dual mechanisms of ictal high frequency oscillations in human rhythmic onset seizures

Elliot H. Smith
Edward M. Merricks
Catherine A. Schevon
ResearchOpen Access05 Nov 2020
Scientific Reports

Volume: 10, P: 1-14
Deep brain stimulation for refractory obsessive-compulsive disorder (OCD): emerging or established therapy?

Hemmings Wu
Marwan Hariz
Bart Nuttin
ReviewsOpen Access03 Nov 2020
Molecular Psychiatry

Volume: 26, P: 60-65
Unsupervised machine-learning classification of electrophysiologically active electrodes during human cognitive task performance

Krishnakant V. Saboo
Yogatheesan Varatharajah
Michal T. Kucewicz
ResearchOpen Access22 Nov 2019
Scientific Reports

Volume: 9, P: 1-14
Evolution of gamma knife capsulotomy for intractable obsessive-compulsive disorder

Euripedes C. Miguel
Antonio C. Lopes
Sameer A. Sheth
ReviewsOpen Access09 May 2018
Molecular Psychiatry

Volume: 24, P: 218-240

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