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Nature Immunology (2)

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Reply to: Apolipoprotein C3 induces inflammasome activation only in its delipidated form

Stephen Zewinger
Jochen Reiser
Thimoteus Speer
Research13 Feb 2023
Nature Immunology

Volume: 24, P: 412-413
Apolipoprotein C3 induces inflammation and organ damage by alternative inflammasome activation

Overabundance of apolipoprotein C3 (ApoC3) is associated with atherosclerosis. Speer and colleagues demonstrate that ApoC3 activates the NLRP3 inflammasome via a non-canonical pathway contributing to inflammation and development of atherosclerosis.

Stephen Zewinger
Jochen Reiser
Thimoteus Speer
Research09 Dec 2019
Nature Immunology

Volume: 21, P: 30-41

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Reply to: Apolipoprotein C3 induces inflammasome activation only in its delipidated form

Apolipoprotein C3 induces inflammation and organ damage by alternative inflammasome activation

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