Nature Search

In utero surgery rescues neurological function at birth in sheep with spina bifida

Martin Meuli
Claudia Meuli-Simmen
N. Scott Adzick
Research01 Apr 1995
Nature Medicine

Volume: 1, P: 342-347
A first-in-class leucyl-tRNA synthetase inhibitor, ganfeborole, for rifampicin-susceptible tuberculosis: a phase 2a open-label, randomized trial

A new inhibitor of Mycobacterium tuberculosis leucyl-tRNA synthetase is associated with bactericidal activity in humans and may be a candidate for combination therapy of tuberculosis.

Andreas H. Diacon
Clifton E. Barry III
David Barros Aguirre
ResearchOpen Access16 Feb 2024
Nature Medicine

Volume: 30, P: 896-904
How much do van der Waals dispersion forces contribute to molecular recognition in solution?

Attractive van der Waals dispersion forces have been implicated in mechanisms as diverse as gecko adhesion and anaesthesia. Now, it has been found using synthetic molecular balances that dispersion forces between alkyl chains are an order of magnitude weaker in solution than they are in the gas phase.

Lixu Yang
Catherine Adam
Scott L. Cockroft
Research20 Oct 2013
Nature Chemistry

Volume: 5, P: 1006-1010
Membrane messengers

Life has evolved elaborate means of communicating essential chemical information across cell membranes. Inspired by biology, two new artificial mechanisms have now been developed that use synthetic messenger molecules to relay chemical signals into or across lipid membranes.

Scott L. Cockroft
News & Views21 Apr 2017
Nature Chemistry

Volume: 9, P: 406-407
High-throughput RNA structure probing reveals critical folding events during early 60S ribosome assembly in yeast

Ribosome biogenesis is a dynamic process that involves the ordered assembly of ribosomal proteins and numerous RNA structural rearrangements. Here the authors apply ChemModSeq, a high-throughput RNA structure probing method, to quantitatively measure changes in RNA flexibility during the nucleolar stages of 60S assembly in yeast.

Elena Burlacu
Fredrik Lackmann
Sander Granneman
ResearchOpen Access28 Sept 2017
Nature Communications

Volume: 8, P: 1-14
Transcription forms and remodels supercoiling domains unfolding large-scale chromatin structures

A genome-wide mapping approach of DNA supercoiling in cells demonstrates that the genome is organized in supercoiling domains. Domains are formed and remodeled by transcription and topoisomerase activity and are flanked by GC-AT boundaries and CTCF binding sites. DNA supercoiling impacts on higher levels of chromatin organization and 'underwound' domains correlate with transcriptional activity.

Catherine Naughton
Nicolaos Avlonitis
Nick Gilbert
Research17 Feb 2013
Nature Structural & Molecular Biology

Volume: 20, P: 387-395
Response guided therapy for reducing duration of direct acting antivirals in chronic hepatitis C infected patients: a Pilot study

Ohad Etzion
Harel Dahari
Amir Shlomai
ResearchOpen Access20 Oct 2020
Scientific Reports

Volume: 10, P: 1-9

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In utero surgery rescues neurological function at birth in sheep with spina bifida

A first-in-class leucyl-tRNA synthetase inhibitor, ganfeborole, for rifampicin-susceptible tuberculosis: a phase 2a open-label, randomized trial

How much do van der Waals dispersion forces contribute to molecular recognition in solution?

Membrane messengers

High-throughput RNA structure probing reveals critical folding events during early 60S ribosome assembly in yeast

Transcription forms and remodels supercoiling domains unfolding large-scale chromatin structures

Response guided therapy for reducing duration of direct acting antivirals in chronic hepatitis C infected patients: a Pilot study

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In utero surgery rescues neurological function at birth in sheep with spina bifida

A first-in-class leucyl-tRNA synthetase inhibitor, ganfeborole, for rifampicin-susceptible tuberculosis: a phase 2a open-label, randomized trial

How much do van der Waals dispersion forces contribute to molecular recognition in solution?

Membrane messengers

High-throughput RNA structure probing reveals critical folding events during early 60S ribosome assembly in yeast

Transcription forms and remodels supercoiling domains unfolding large-scale chromatin structures

Response guided therapy for reducing duration of direct acting antivirals in chronic hepatitis C infected patients: a Pilot study

Search

Quick links