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Mitochondrial aconitase suppresses immunity by modulating oxaloacetate and the mitochondrial unfolded protein response

Mitochondrial function has been linked to immunity but the role of the Krebs’s cycle in regards the immune response is not well characterised. Here the authors show that Krebs’s cycle enzyme ACO2 suppresses immunity via modulation of oxaloacetate and the mitochondrial unfolded protein response.

Eunah Kim
Andrea Annibal
Seung-Jae V. Lee
ResearchOpen Access22 Jun 2023
Nature Communications

Volume: 14, P: 1-16
Transcription-dependent targeting of Hda1C to hyperactive genes mediates H4-specific deacetylation in yeast

In yeast, Hda1 histone deacetylase complex (Hda1C) preferentially deacetylates H3 and H2B, but has also been implicated in global H4 deacetylation. Here, the authors provide evidence that Hda1C binds to hyperactive genes, where it specifically deacetylates H4 to partially inhibit elongation, suggesting a role for Hda1C in elongation by specifically deacetylating H4 at highly transcribed regions.

So Dam Ha
Seokjin Ham
TaeSoo Kim
ResearchOpen Access19 Sept 2019
Nature Communications

Volume: 10, P: 1-14
A PTEN variant uncouples longevity from impaired fitness in Caenorhabditis elegans with reduced insulin/IGF-1 signaling

Mutations in daf-2/insulin/IGF-1 receptor impair the growth and reproduction of C. elegans but conversely enhance immunity and lifespan. Here, the authors show that a missense mutation in the gene retains the effects on lifespan and immunity and improves motility.

Hae-Eun H. Park
Wooseon Hwang
Seung-Jae V. Lee
ResearchOpen Access24 Sept 2021
Nature Communications

Volume: 12, P: 1-15
Targeted erasure of DNA methylation by TET3 drives adipogenic reprogramming and differentiation

Park et al. shed light on the dynamics of DNA demethylation during adipocyte differentiation, which is shown to be regulated by the transcription factor C/EBPδ and the DNA methylation eraser TET3.

Jeu Park
Do Hoon Lee
Jae Bum Kim
Research04 Jul 2022
Nature Metabolism

Volume: 4, P: 918-931
Advances in transcriptome analysis of human brain aging

Seokjin Ham
Seung-Jae V. Lee
ReviewsOpen Access26 Nov 2020
Experimental & Molecular Medicine

Volume: 52, P: 1787-1797
RNA surveillance via nonsense-mediated mRNA decay is crucial for longevity in daf-2/insulin/IGF-1 mutant C. elegans

The decline of DNA and protein quality control contributes to organismal ageing. Here, Sonet al. report that nonsense-mediated mRNA decay, a RNA quality control mechanism, is enhanced in long-lived daf-2 mutant worms and contributes to their longevity by regulating expression of the yars-2/tyrosyl tRNA synthetase.

Heehwa G. Son
Mihwa Seo
Seung-Jae V. Lee
ResearchOpen Access09 Mar 2017
Nature Communications

Volume: 8, P: 1-11
Dietary antigens suppress the proliferation of type 2 innate lymphoid cells by restraining homeostatic IL-25 production

Minji Lee
Hyun-Ja Ko
You Jeong Lee
ResearchOpen Access06 May 2022
Scientific Reports

Volume: 12, P: 1-10
Epigenetic analysis in rheumatoid arthritis synoviocytes

Seokjin Ham
Jae-Bum Bae
Tae-Young Roh
ResearchOpen Access22 Feb 2019
Experimental & Molecular Medicine

Volume: 51, P: 1-13

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Mitochondrial aconitase suppresses immunity by modulating oxaloacetate and the mitochondrial unfolded protein response

Transcription-dependent targeting of Hda1C to hyperactive genes mediates H4-specific deacetylation in yeast

A PTEN variant uncouples longevity from impaired fitness in Caenorhabditis elegans with reduced insulin/IGF-1 signaling

Targeted erasure of DNA methylation by TET3 drives adipogenic reprogramming and differentiation

Advances in transcriptome analysis of human brain aging

RNA surveillance via nonsense-mediated mRNA decay is crucial for longevity in daf-2/insulin/IGF-1 mutant C. elegans

Dietary antigens suppress the proliferation of type 2 innate lymphoid cells by restraining homeostatic IL-25 production

Epigenetic analysis in rheumatoid arthritis synoviocytes

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