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Linkage disequilibrium in the 13q12 region in Finnish late onset Alzheimer's disease patients

Mikko Hiltunen
Arto Mannermaa
Hilkka Soininen
Research01 Sept 1999
European Journal of Human Genetics

Volume: 7, P: 652-658
Identification of a novel 4.6-kb genomic deletion in presenilin-1 gene which results in exclusion of exon 9 in a Finnish early onset Alzheimer's disease family: an Alu core sequence-stimulated recombination?

Mikko Hiltunen
Seppo Helisalmi
Hilkka Soininen
Research15 Jun 2000
European Journal of Human Genetics

Volume: 8, P: 259-266
Transferability of European-derived Alzheimer’s disease polygenic risk scores across multiancestry populations

Polygenic risk scores for Alzheimer’s disease derived from individuals of European ancestry can show improved performance in multiancestry settings after incorporating genome-wide association summary statistics from diverse populations.

Aude Nicolas
Richard Sherva
Jean-Charles Lambert
ResearchOpen Access18 Jun 2025
Nature Genetics

P: 1-13
Two exonic single nucleotide polymorphisms in the microsomal epoxide hydrolase gene are jointly associated with preeclampsia

Jaana Laasanen
Eeva-Liisa Romppanen
Seppo Heinonen
Research13 Aug 2002
European Journal of Human Genetics

Volume: 10, P: 569-573
Susceptibility to pre-eclampsia in Finnish women is associated with R485K polymorphism in the factor V gene, not with Leiden mutation

Fareeza Faisel
Eeva-Liisa Romppanen
Seppo Heinonen
Research03 Dec 2003
European Journal of Human Genetics

Volume: 12, P: 187-191
Genetic meta-analysis of diagnosed Alzheimer’s disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing

Large genome-wide meta-analysis of clinically diagnosed late-onset Alzheimer’s disease (LOAD) from 94,437 individuals identifies new LOAD risk loci and implicates Aβ formation, tau protein binding, immune response and lipid metabolism.

Brian W. Kunkle
Benjamin Grenier-Boley
Margaret A. Pericak-Vance
Research28 Feb 2019
Nature Genetics

Volume: 51, P: 414-430
New insights into the genetic etiology of Alzheimer’s disease and related dementias

Meta-analysis of genome-wide association studies on Alzheimer’s disease and related dementias identifies new loci and enables generation of a new genetic risk score associated with the risk of future Alzheimer’s disease and dementia.

Céline Bellenguez
Fahri Küçükali
Jean-Charles Lambert
ResearchOpen Access04 Apr 2022
Nature Genetics

Volume: 54, P: 412-436
Loss-of-function variants in ABCA7 confer risk of Alzheimer's disease

Stacy Steinberg, Hreinn Stefansson, Thorlakur Jonsson and colleagues found that rare variants predicted to alter the function of ABCA7 are associated with risk of Alzheimer's disease. The association was found in Iceland and replicated in northern Europe and the United States.

Stacy Steinberg
Hreinn Stefansson
Kari Stefansson
Research25 Mar 2015
Nature Genetics

Volume: 47, P: 445-447
Common variants in Alzheimer’s disease and risk stratification by polygenic risk scores

Known genetic loci account for only a fraction of the genetic contribution to Alzheimer’s disease. Here, the authors have performed a large genome-wide meta-analysis comprising 409,435 individuals to discover 6 new loci and demonstrate the efficacy of an Alzheimer’s disease polygenic risk score.

Itziar de Rojas
Sonia Moreno-Grau
Agustín Ruiz
ResearchOpen Access07 Jun 2021
Nature Communications

Volume: 12, P: 1-16
Estrogen receptor beta gene variants are associated with increased risk of Alzheimer's disease in women

Mia Pirskanen
Mikko Hiltunen
Hilkka Soininen
Research08 Jun 2005
European Journal of Human Genetics

Volume: 13, P: 1000-1006
Low prevalence of APP duplications in Swedish and Finnish patients with early-onset Alzheimer's disease

Elin S Blom
Jayashree Viswanathan
Mikko Hiltunen
Research28 Nov 2007
European Journal of Human Genetics

Volume: 16, P: 171-175
Genome-wide association study identifies variants at CLU and CR1 associated with Alzheimer's disease

Philippe Amouyel and colleagues report a genome-wide association study for Alzheimer's disease. They identify variants within CLU and CR1 associated with susceptibility to late-onset Alzheimer's disease.

Jean-Charles Lambert
Simon Heath
Philippe Amouyel
Research06 Sept 2009
Nature Genetics

Volume: 41, P: 1094-1099
Rare coding variants in PLCG2, ABI3, and TREM2 implicate microglial-mediated innate immunity in Alzheimer's disease

Sven van der Lee, Julie Williams, Gerard Schellenberg and colleagues identify rare coding variants in PLCG2, ABI3 and TREM2 associated with Alzheimer's disease. These genes are highly expressed in microglia and provide additional evidence that the microglia-mediated immune response contributes to the development of Alzheimer's disease.

Rebecca Sims
Sven J van der Lee
Gerard D Schellenberg
Research17 Jul 2017
Nature Genetics

Volume: 49, P: 1373-1384
Author Correction: Common variants in Alzheimer’s disease and risk stratification by polygenic risk scores

Itziar de Rojas
Sonia Moreno-Grau
Agustín Ruiz
Amendments and CorrectionsOpen Access09 Feb 2023
Nature Communications

Volume: 14, P: 1-2
Author Correction: Genetic meta-analysis of diagnosed Alzheimer’s disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing

Brian W. Kunkle
Benjamin Grenier-Boley
Margaret A. Pericak-Vance
Amendments and Corrections15 Aug 2019
Nature Genetics

Volume: 51, P: 1423-1424
Whole exome sequencing study identifies novel rare and common Alzheimer’s-Associated variants involved in immune response and transcriptional regulation

Joshua C. Bis
Xueqiu Jian
Lindsay A. Farrer
ResearchOpen Access14 Aug 2018
Molecular Psychiatry

Volume: 25, P: 1859-1875
Correction: Whole exome sequencing study identifies novel rare and common Alzheimer’s-Associated variants involved in immune response and transcriptional regulation

Joshua C. Bis
Xueqiu Jian
Lindsay A. Farrer
Amendments and CorrectionsOpen Access21 Oct 2019
Molecular Psychiatry

Volume: 25, P: 1901-1903

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Linkage disequilibrium in the 13q12 region in Finnish late onset Alzheimer's disease patients

Identification of a novel 4.6-kb genomic deletion in presenilin-1 gene which results in exclusion of exon 9 in a Finnish early onset Alzheimer's disease family: an Alu core sequence-stimulated recombination?

Transferability of European-derived Alzheimer’s disease polygenic risk scores across multiancestry populations

Two exonic single nucleotide polymorphisms in the microsomal epoxide hydrolase gene are jointly associated with preeclampsia

Susceptibility to pre-eclampsia in Finnish women is associated with R485K polymorphism in the factor V gene, not with Leiden mutation

Genetic meta-analysis of diagnosed Alzheimer’s disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing

New insights into the genetic etiology of Alzheimer’s disease and related dementias

Loss-of-function variants in ABCA7 confer risk of Alzheimer's disease

Common variants in Alzheimer’s disease and risk stratification by polygenic risk scores

Estrogen receptor beta gene variants are associated with increased risk of Alzheimer's disease in women

Low prevalence of APP duplications in Swedish and Finnish patients with early-onset Alzheimer's disease

Genome-wide association study identifies variants at CLU and CR1 associated with Alzheimer's disease

Rare coding variants in PLCG2, ABI3, and TREM2 implicate microglial-mediated innate immunity in Alzheimer's disease

Author Correction: Common variants in Alzheimer’s disease and risk stratification by polygenic risk scores

Author Correction: Genetic meta-analysis of diagnosed Alzheimer’s disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing

Whole exome sequencing study identifies novel rare and common Alzheimer’s-Associated variants involved in immune response and transcriptional regulation

Correction: Whole exome sequencing study identifies novel rare and common Alzheimer’s-Associated variants involved in immune response and transcriptional regulation

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