Nature Search

Ancient DNA reveals the prehistory of the Uralic and Yeniseian peoples

Genome-wide sequencing of 180 ancient individuals shows a continuous gradient of ancestry in Early-to-Mid-Holocene hunter-gatherers from the Baltic to the Transbaikal region and distinct contemporaneous groups in Northeast Siberia, and provides insights into the origins of modern Uralic and Yeniseian speakers.

Tian Chen Zeng
Leonid A. Vyazov
David Reich
Research02 Jul 2025
Nature

P: 1-11
Frequent cases of RAS-mutated Down syndrome acute lymphoblastic leukaemia lack JAK2 mutations

For children with acute lymphoblastic leukaemia (ALL), those with Down syndrome (DS) have decreased survival compared with children without DS. Here, the authors use exome sequencing to characterise the mutational landscape of patients with both ALL and DS and highlight genes related to survival and relapse.

Sergey I. Nikolaev
Marco Garieri
Stylianos E. Antonarakis
Research08 Aug 2014
Nature Communications

Volume: 5, P: 1-6
Exome sequencing identifies recurrent somatic MAP2K1 and MAP2K2 mutations in melanoma

Sergey Nikolaev, Stylianos Antonarakis and colleagues report exome sequencing of seven melanoma cell lines and matched germline cells. They identify recurring somatic mutations in MAP2K1 and MAP2K2 occurring at an overall frequency of 8%.

Sergey I Nikolaev
Donata Rimoldi
Stylianos E Antonarakis
Research25 Dec 2011
Nature Genetics

Volume: 44, P: 133-139
Genomic analysis identifies new drivers and progression pathways in skin basal cell carcinoma

Sergey Nikolaev, Stylianos Antonarakis and colleagues analyze the genetic architecture of 293 basal cell carcinomas (BCCs) and characterize their mutational landscape. They observe UV signature mutations and identify new driver mutations in MYCN, PTPN14 and LATS1 in BCC.

Ximena Bonilla
Laurent Parmentier
Sergey I Nikolaev
Research07 Mar 2016
Nature Genetics

Volume: 48, P: 398-406
Extrachromosomal driver mutations in glioblastoma and low-grade glioma

Human cancers are characterised by increased levels of genomic instability. Here, the authors show that a new class of mutation that occurs in glioblastoma, double minutes, may facilitate tumour drug resistance by acquiring gain-of-function extrachromosomal mutations, mediated by focal amplifications.

Sergey Nikolaev
Federico Santoni
Stylianos E. Antonarakis
Research04 Dec 2014
Nature Communications

Volume: 5, P: 1-7
Genomic mutation landscape of skin cancers from DNA repair-deficient xeroderma pigmentosum patients

Xeroderma pigmentosum (XP) is a rare genetic disorder that is associated with a higher risk of skin cancer. Here, the authors analyse the genomes of skin cancers from patients across five different XP groups, revealing genetic and molecular factors related to the mutational profile and UV-related mutagenesis in XP.

Andrey A. Yurchenko
Fatemeh Rajabi
Sergey I. Nikolaev
ResearchOpen Access04 May 2023
Nature Communications

Volume: 14, P: 1-17
RAS mutations drive proliferative chronic myelomonocytic leukemia via a KMT2A-PLK1 axis

Chronic myelomonocytic leukaemia is classified as proliferative (pCMML) or dysplastic based on the white blood cell counts but biological differences are unclear. Here, the authors show genetic, transcriptomic and epigenomic differences between these two subtypes establishing that pCMML is RAS-pathway driven and that inhibiting RAS-driven PLK1 expression is a viable therapeutic target.

Ryan M. Carr
Denis Vorobyev
Mrinal M. Patnaik
ResearchOpen Access18 May 2021
Nature Communications

Volume: 12, P: 1-18
XPC deficiency increases risk of hematologic malignancies through mutator phenotype and characteristic mutational signature

Xeroderma Pigmentosum group C (XP-C) is a rare genetic disorder characterised by deficient DNA repair leading to skin and internal cancer, but the latter is not well understood molecularly. Here the authors sequence genomes of non-skin cancers from XP-C patients to unravel its mutational patterns.

Andrey A. Yurchenko
Ismael Padioleau
Sergey Nikolaev
ResearchOpen Access17 Nov 2020
Nature Communications

Volume: 11, P: 1-11
Early-onset gynecological tumors in DNA repair-deficient xeroderma pigmentosum group C patients: a case series

Yurchenko et al. describe a series of young xeroderma pigmentosum group C patients with early-onset gynecological tumors. DICER1 mutations are seen in all tumors, along with increased mutagenesis and a mutational profile characteristic of nucleotide excision repair deficiency.

Andrey. A. Yurchenko
Brice Fresneau
Sergey I. Nikolaev
ResearchOpen Access11 Aug 2023
Communications Medicine

Volume: 3, P: 1-8
Quantum transport evidence of Weyl fermions in an epitaxial ferromagnetic oxide

Despite various predictions, the evidence of Weyl fermions in oxide materials remains elusive. Here, the authors show evidence of Weyl fermions in quantum transport measurements in an epitaxial ferromagnetic oxide SrRuO₃.

Kosuke Takiguchi
Yuki K. Wakabayashi
Hideki Yamamoto
ResearchOpen Access09 Oct 2020
Nature Communications

Volume: 11, P: 1-12
Safety and efficacy of the low-dose memory (CD45RA-depleted) donor lymphocyte infusion in recipients of αβ T cell-depleted haploidentical grafts: results of a prospective randomized trial in high-risk childhood leukemia

Maria Dunaikina
Zhanna Zhekhovtsova
Michael Maschan
Research16 Feb 2021
Bone Marrow Transplantation

Volume: 56, P: 1614-1624
Significant Dzyaloshinskii–Moriya interaction at graphene–ferromagnet interfaces due to the Rashba effect

Authors investigate graphene/cobalt and graphene/nickel interfaces, and observe a non-zero Dzyaloshinskii–Moriya interaction that they attribute to the Rashba effect; calculations suggest the effect can be enhanced in van der Waals heterostructures.

Hongxin Yang
Gong Chen
Mairbek Chshiev
Research28 May 2018
Nature Materials

Volume: 17, P: 605-609
Natural repeated backcrosses lead to triploidy and tetraploidy in parthenogenetic butterfly lizards (Leiolepis: Agamidae)

Eduard Galoyan
Roman Nazarov
Lukáš Kratochvíl
ResearchOpen Access24 Jan 2025
Scientific Reports

Volume: 15, P: 1-15
Error-prone bypass of DNA lesions during lagging-strand replication is a common source of germline and cancer mutations

Analysis of mutational asymmetry with respect to the direction of replication and transcription suggests that error-prone damage bypass on the lagging strand has a major role in human germline and cancer mutations.

Vladimir B. Seplyarskiy
Evgeny E. Akkuratov
Shamil R. Sunyaev
Research03 Dec 2018
Nature Genetics

Volume: 51, P: 36-41
Identification and analysis of functional elements in 1% of the human genome by the ENCODE pilot project

The next step after sequencing a genome is to figure out how the cell actually uses it as an instruction manual. A large international consortium has examined 1% of the genome for what part is transcribed, where proteins are bound, what the chromatin structure looks like, and how the sequence compares to that of other organisms.

Ewan Birney
John A. Stamatoyannopoulos
Pieter J. de Jong
Research14 Jun 2007
Nature

Volume: 447, P: 799-816
Memristive Sisyphus circuit for clock signal generation

Yuriy V. Pershin
Sergey N. Shevchenko
Franco Nori
ResearchOpen Access20 May 2016
Scientific Reports

Volume: 6, P: 1-6
Tunable vertical ferroelectricity and ___domain walls by interlayer sliding in β-ZrI₂

Xiaonan Ma
Chang Liu
Sergey A. Nikolaev
ResearchOpen Access28 Oct 2021
npj Computational Materials

Volume: 7, P: 1-9
Multiferroic kinks and spin-flop transition in Ni₂InSbO₆ from first principles

Ryota Ono
Igor Solovyev
Sergey Artyukhin
ResearchOpen Access03 Jun 2024
npj Spintronics

Volume: 2, P: 1-10
High-mobility two-dimensional carriers from surface Fermi arcs in magnetic Weyl semimetal films

Shingo Kaneta-Takada
Yuki K. Wakabayashi
Hideki Yamamoto
ResearchOpen Access07 Oct 2022
npj Quantum Materials

Volume: 7, P: 1-12
Light-driven anisotropy of 2D metal-organic framework single crystal for repeatable optical modulation

Structural transformations offer a route to control functional properties but it is difficult to design metal-organic frameworks with multiple and fast transformations. Here, a 2D metal-organic framework was designed with continuous structural transformations driven by light and used for optical modulation.

Yuliya A. Kenzhebayeva
Nikita K. Kulachenkov
Valentin A. Milichko
ResearchOpen Access10 Apr 2024
Communications Materials

Volume: 5, P: 1-11
Engineering of Fe-pnictide heterointerfaces by electrostatic principles

A classification of Fe-pnictide heterointerfaces based on electrostatic principles into initially compensated and uncompensated interfaces is proposed and used for tailoring the interfacial microstructure and superconducting properties. We show that the heterointerface between LnOFeAs (Ln = La, Sm) and BaFe₂As₂ is nonpolar and remains clean and coherent with Co²⁺ addition. Co-diffusion results in superconductivity across the whole bilayer. In contrast, IFL formation occurs after adding O²⁻, and superconductivity with a 2D signature develops with time.

Silvia Haindl
Sergey Nikolaev
Ian MacLaren
ResearchOpen Access29 Oct 2021
NPG Asia Materials

Volume: 13, P: 1-10
N-___domain of angiotensin-converting enzyme hydrolyzes human and rat amyloid-β(1-16) peptides as arginine specific endopeptidase potentially enhancing risk of Alzheimer’s disease

Elena V. Kugaevskaya
Alexander V. Veselovsky
Sergey A. Kozin
ResearchOpen Access10 Jan 2018
Scientific Reports

Volume: 8, P: 1-12
An alternative approach to establishing unbiased colorectal cancer risk estimation in Lynch syndrome

Manon Suerink
Mar Rodríguez-Girondo
Maartje Nielsen
Research17 Jun 2019
Genetics in Medicine

Volume: 21, P: 2706-2712
Snap-through transition of buckled graphene membranes for memcapacitor applications

Ruslan D. Yamaletdinov
Oleg V. Ivakhnenko
Yuriy V. Pershin
ResearchOpen Access23 Feb 2018
Scientific Reports

Volume: 8, P: 1-13

Search

Ancient DNA reveals the prehistory of the Uralic and Yeniseian peoples

Frequent cases of RAS-mutated Down syndrome acute lymphoblastic leukaemia lack JAK2 mutations

Exome sequencing identifies recurrent somatic MAP2K1 and MAP2K2 mutations in melanoma

Genomic analysis identifies new drivers and progression pathways in skin basal cell carcinoma

Extrachromosomal driver mutations in glioblastoma and low-grade glioma

Genomic mutation landscape of skin cancers from DNA repair-deficient xeroderma pigmentosum patients

RAS mutations drive proliferative chronic myelomonocytic leukemia via a KMT2A-PLK1 axis

XPC deficiency increases risk of hematologic malignancies through mutator phenotype and characteristic mutational signature

Early-onset gynecological tumors in DNA repair-deficient xeroderma pigmentosum group C patients: a case series

Quantum transport evidence of Weyl fermions in an epitaxial ferromagnetic oxide

Safety and efficacy of the low-dose memory (CD45RA-depleted) donor lymphocyte infusion in recipients of αβ T cell-depleted haploidentical grafts: results of a prospective randomized trial in high-risk childhood leukemia

Significant Dzyaloshinskii–Moriya interaction at graphene–ferromagnet interfaces due to the Rashba effect

Natural repeated backcrosses lead to triploidy and tetraploidy in parthenogenetic butterfly lizards (Leiolepis: Agamidae)

Error-prone bypass of DNA lesions during lagging-strand replication is a common source of germline and cancer mutations

Identification and analysis of functional elements in 1% of the human genome by the ENCODE pilot project

Memristive Sisyphus circuit for clock signal generation

Tunable vertical ferroelectricity and ___domain walls by interlayer sliding in β-ZrI₂

Multiferroic kinks and spin-flop transition in Ni₂InSbO₆ from first principles

High-mobility two-dimensional carriers from surface Fermi arcs in magnetic Weyl semimetal films

Light-driven anisotropy of 2D metal-organic framework single crystal for repeatable optical modulation

Engineering of Fe-pnictide heterointerfaces by electrostatic principles

N-___domain of angiotensin-converting enzyme hydrolyzes human and rat amyloid-β(1-16) peptides as arginine specific endopeptidase potentially enhancing risk of Alzheimer’s disease

An alternative approach to establishing unbiased colorectal cancer risk estimation in Lynch syndrome

Snap-through transition of buckled graphene membranes for memcapacitor applications

Search

Quick links

Search

Filter By:

Search

Quick links