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Efficient evolution of human antibodies from general protein language models

A general protein language model guides protein evolution with 20 or fewer variants needed for testing.

Brian L. Hie
Varun R. Shanker
Peter S. Kim
ResearchOpen Access24 Apr 2023
Nature Biotechnology

Volume: 42, P: 275-283
Author Correction: A ferritin-based COVID-19 nanoparticle vaccine that elicits robust, durable, broad-spectrum neutralizing antisera in non-human primates

Payton A.-B. Weidenbacher
Mrinmoy Sanyal
Peter S. Kim
Amendments and CorrectionsOpen Access05 Oct 2023
Nature Communications

Volume: 14, P: 1
A ferritin-based COVID-19 nanoparticle vaccine that elicits robust, durable, broad-spectrum neutralizing antisera in non-human primates

Here the authors develop a ferritin-based protein nanoparticle vaccine candidate for SARS-CoV-2, and show induction of neutralizing antibodies to variants of concern, including Omicron BQ.1, in non-human primates after initial immunization and a booster dose.

Payton A.-B. Weidenbacher
Mrinmoy Sanyal
Peter S. Kim
ResearchOpen Access17 Apr 2023
Nature Communications

Volume: 14, P: 1-13
Vaccine design via antigen reorientation

A new design for vaccines consisting of reorienting the viral glycoprotein in an ‘upside-down’ configuration broadens immune responses to diverse influenza subtypes and serves as a proof of concept for designing a universal flu vaccine.

Duo Xu
Joshua J. Carter
Peter S. Kim
ResearchOpen Access15 Jan 2024
Nature Chemical Biology

Volume: 20, P: 1012-1021

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Efficient evolution of human antibodies from general protein language models

Author Correction: A ferritin-based COVID-19 nanoparticle vaccine that elicits robust, durable, broad-spectrum neutralizing antisera in non-human primates

A ferritin-based COVID-19 nanoparticle vaccine that elicits robust, durable, broad-spectrum neutralizing antisera in non-human primates

Vaccine design via antigen reorientation

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