Nature Search

Reply to: A finding of sex similarities rather than differences in COVID-19 outcomes

Takehiro Takahashi
Mallory K. Ellingson
Akiko Iwasaki
Research22 Sept 2021
Nature

Volume: 597, P: E10-E11
Linkage disequilibrium in the human genome

David E. Reich
Michele Cargill
Eric S. Lander
Research10 May 2001
Nature

Volume: 411, P: 199-204
Author Correction: Delayed production of neutralizing antibodies correlates with fatal COVID-19

Carolina Lucas
Jon Klein
Akiko Iwasaki
Amendments and Corrections18 Jun 2021
Nature Medicine

Volume: 27, P: 1309
Single-cell multi-omics reveals dyssynchrony of the innate and adaptive immune system in progressive COVID-19

SARS-CoV-2 infection can lead to progressive pathology in patients with COVID-19, but information for this disease progression is sparse. Here the authors use multi-omics approach to profile the immune responses of patients, assessing immune repertoire and effects of tocilizumab treatments, to find a dyssynchrony between innate and adaptive immunity in progressive COVID-19.

Avraham Unterman
Tomokazu S. Sumida
Charles S. Dela Cruz
ResearchOpen Access21 Jan 2022
Nature Communications

Volume: 13, P: 1-23
Longitudinal analyses reveal immunological misfiring in severe COVID-19

A longitudinal analysis of immune responses in patients with moderate or severe COVID-19 identifies a maladapted immune response profile linked to severe disease.

Carolina Lucas
Patrick Wong
Akiko Iwasaki
Research27 Jul 2020
Nature

Volume: 584, P: 463-469
Delayed production of neutralizing antibodies correlates with fatal COVID-19

A longitudinal analysis of humoral immune responses in patients with COVID-19 with varying disease severities reveals that mortality does not correlate with antiviral antibody levels but, instead, with slower seroconversion.

Carolina Lucas
Jon Klein
Akiko Iwasaki
Research05 May 2021
Nature Medicine

Volume: 27, P: 1178-1186
Sex differences in immune responses that underlie COVID-19 disease outcomes

Male patients with COVID-19 have higher plasma levels of innate immune cytokines and chemokines such as IL-8, IL-18 and CCL5 and more non-classical monocytes than female patients, whereas female patients mount robust T cell activation maintained even in older age.

Takehiro Takahashi
Mallory K. Ellingson
Akiko Iwasaki
Research26 Aug 2020
Nature

Volume: 588, P: 315-320
Diverse functional autoantibodies in patients with COVID-19

Rapid extracellular antigen profiling of a cohort of 194 individuals infected with SARS-CoV-2 uncovers diverse autoantibody responses that affect COVID-19 disease severity, progression and clinical and immunological characteristics.

Eric Y. Wang
Tianyang Mao
Aaron M. Ring
Research19 May 2021
Nature

Volume: 595, P: 283-288
Host-microbe multiomic profiling identifies distinct COVID-19 immune dysregulation in solid organ transplant recipients

Solid organ transplant recipients are at increased risk of infectious disease and have unique molecular pathophysiology. Here the authors use host-microbe profiling to assess SARS-CoV-2 infection and immunity in solid organ transplant recipients, showing enhanced viral abundance, impaired clearance, and increased expression of innate immunity genes.

Harry Pickering
Joanna Schaenman
Charles R. Langelier
ResearchOpen Access10 Jan 2025
Nature Communications

Volume: 16, P: 1-16
Multiscale PHATE identifies multimodal signatures of COVID-19

Disease signatures in high-dimensional biomedical data are detected with a visualization algorithm.

Manik Kuchroo
Jessie Huang
Smita Krishnaswamy
Research28 Feb 2022
Nature Biotechnology

Volume: 40, P: 681-691
IgM N-glycosylation correlates with COVID-19 severity and rate of complement deposition

The role of IgG glycosylation in the immune response has been studied, but less is known about IgM glycosylation. Here the authors characterize glycosylation of SARS-CoV-2 spike specific IgM and show that it correlates with COVID-19 severity and affects complement deposition.

Benjamin S. Haslund-Gourley
Kyra Woloszczuk
Mary Ann Comunale
ResearchOpen Access09 Jan 2024
Nature Communications

Volume: 15, P: 1-19
Analytical sensitivity and efficiency comparisons of SARS-CoV-2 RT–qPCR primer–probe sets

This is a comparative analysis of the performance of the primer–probe sets from four open-source molecular diagnostic assays for SARS-CoV-2 recommended by the World Health Organization.

Chantal B. F. Vogels
Anderson F. Brito
Nathan D. Grubaugh
Research10 Jul 2020
Nature Microbiology

Volume: 5, P: 1299-1305
Features of acute COVID-19 associated with post-acute sequelae of SARS-CoV-2 phenotypes: results from the IMPACC study

Post-acute sequelae of SARS-CoV-2 (PASC) is still not well understood. Here the authors provide patient reported outcomes from 590 hospitalized COVID-19 patients and show association of PASC with higher respiratory SARS-CoV-2 load and circulating antibody titers, and in some an elevation in circulating fibroblast growth factor 21.

Al Ozonoff
Naresh Doni Jayavelu
Nadine Rouphael
ResearchOpen Access03 Jan 2024
Nature Communications

Volume: 15, P: 1-17
High-resolution epitope mapping and characterization of SARS-CoV-2 antibodies in large cohorts of subjects with COVID-19

Using a high throughput, random bacterial peptide display approach applied to patient serum samples, Haynes, Kamath, Bozekowski et al identify the antigens and epitopes that elicit a SARS-CoV-2 humoral response. They identify differences depending on disease severity and further in silico analysis suggests decreased epitope signal for Q677P but not for D614G mutant SARSCoV-2 strains.

Winston A. Haynes
Kathy Kamath
John C. Shon
ResearchOpen Access22 Nov 2021
Communications Biology

Volume: 4, P: 1-14

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