Nature Search

Myc-mediated SDHA acetylation triggers epigenetic regulation of gene expression and tumorigenesis

Li and colleagues show how cMyc promotes tumourigenesis by promoting succinate dehydrogenase complex subunit A acetylation by activating SKP2-mediated degradation of SIRT3. This leads to succinate accumulation and consequent tumour-specific gene expression.

Shi-Ting Li
De Huang
Ping Gao
Research16 Mar 2020
Nature Metabolism

Volume: 2, P: 256-269
Mitochondria-localized MBD2c facilitates mtDNA transcription and drug resistance

The MBD2c splicing variant of MBD2 that is essential for nuclear transcription translocates to the mitochondria to regulate mitochondrial DNA transcription and respiration and is linked to drug resistance in cancer cells.

Yijie Hao
Zilong Zhou
Huafeng Zhang
Research28 Nov 2024
Nature Chemical Biology

Volume: 21, P: 926-938
Carnosine regulation of intracellular pH homeostasis promotes lysosome-dependent tumor immunoevasion

Carnosine is a mobile buffering metabolite. Here the authors link carnosine accumulation, hypoxia and intracellular pH homeostasis in cancer cells as a mechanism of tumor immune evasion via NFX1 degradation and galectin-9 activity.

Ronghui Yan
Pinggen Zhang
Ping Gao
Research04 Jan 2024
Nature Immunology

Volume: 25, P: 483-495
Robustly federated learning model for identifying high-risk patients with postoperative gastric cancer recurrence

Medical data faces isolation and cross-center performance issues. Here, the authors propose a robust federated learning model to identify high-risk postoperative gastric cancer recurrence, achieving promising results across data from four independent medical institutions.

Bao Feng
Jiangfeng Shi
Wansheng Long
ResearchOpen Access25 Jan 2024
Nature Communications

Volume: 15, P: 1-11
A comprehensive dataset of magnetic resonance enterography images with intestinal segment annotations

Zhangnan Zhong
Li Huang
Bingsheng Huang
ResearchOpen Access11 Mar 2025
Scientific Data

Volume: 12, P: 1-7
ENO1 suppresses cancer cell ferroptosis by degrading the mRNA of iron regulatory protein 1

Zhang and colleagues report a function of the glycolytic enzyme α-Enolase 1 in iron homeostasis. In this setting it promotes the mRNA decay of IRP1, thereby suppressing ferroptosis in hepatocellular carcinoma.

Tong Zhang
Linchong Sun
Huafeng Zhang
Research09 Dec 2021
Nature Cancer

Volume: 3, P: 75-89
Nomograms to predict the long-term prognosis for non-metastatic invasive lobular breast carcinoma: a population-based study

Ying Guan
Shi-Ting Huang
Bin-Bin Yu
ResearchOpen Access22 Aug 2024
Scientific Reports

Volume: 14, P: 1-12
Inhibition of HIF-prolyl hydroxylase promotes renal tubule regeneration via the reprogramming of renal proximal tubular cells

Jing Li
Li-ting Chen
Fu-jian Zhang
Research07 Jan 2025
Acta Pharmacologica Sinica

Volume: 46, P: 1002-1015
The association between urinary phthalate metabolites and serum thyroid function in US adolescents

Shi-ting Xiang
Yuhan Cao
Xun Li
ResearchOpen Access18 Jul 2023
Scientific Reports

Volume: 13, P: 1-8
The concurrence of sexual violence and physical fighting among adolescent suicide ideators and the risk of attempted suicide

Xun Li
Shi-Ting Xiang
Jie Dong
ResearchOpen Access28 Mar 2022
Scientific Reports

Volume: 12, P: 1-12

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