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Low solubility and stability of Escherichia coli produced single chain variable fragments (scFvs) restrict their applications. Here the authors report a 33-residue peptide tag which simultaneously increases the solubility and thermostability of multiple scFvs produced in Escherichia coli SHuffle strain.

Acorales is sister to all other monocots and contains only one family with just one genus, Acorus. Here, the authors assemble the genome of the diploid Ac. gramineus and the tetraploid Ac. calamus, reconstruct an ancestral monocot karyotype and gene toolkit, and discuss the origin and evolution of the two species and other monocots.

The micro-thermoelectric coolers face challenges in high-performance material preparation and high-density device integration. Here, the authors combine Bi₂Te₃-based film prepared by powder direct molding with micro-thermoelectric cooler integrated via phase-change batch transfer.

How hippocampal cells encode space during development is not well understood. Using longitudinal calcium imaging, the authors show that a subset of place cells early in development consistently represented spatial information across environments and days, while a later-developing subset of place cells showed enhanced spatial coding ability.

Electrosynthesis of multicarbon products from CO₂ is restricted by the proton-rich conditions in strong acids leading to unfavourable hydrogen evolution. Now a heterogeneous catalyst adlayer composed of covalent organic framework nanoparticles and cation-exchange ionomers is reported to regulate the local pH, suppressing H₂ generation and promoting multicarbon formation.

Tailoring the composition of organic cations enables manipulating the recombination rates of perovskites. Optimized solution-processed perovskite emitters fabricated on silicon exhibit up to 42.6-MHz modulation bandwidth and 50-Mbps data rate.

Genome-wide association meta-analyses in populations of East Asian and European ancestries identify variant–trait associations for 44 hippocampal traits and provide insight into the genetic architectures of hippocampal and subfield volumes.

Hepatobiliary MRI can be enhanced by an ultrasmall nanoparticle composed of a manganese ferrite core and surface ligands binding to hepatocyte-specific transmembrane metal and anion transporters, as shown in small and large animals.

The development of a tandem catalyst, consisting of two distinct nanoscale-engineered layers, enables efficient multicarbon production with high CO₂ utilization in an acidic CO₂ electroreduction environment.

The chromatin accessibility landscape and gene regulatory network of pancreatic cancer has not been fully characterised. Here, the authors perform multi-omics analysis of 84 pancreatic cancer organoid lines and reveal gene regulatory networks and distinct molecular subtypes.

Food consumption has triggered considerable quantities of greenhouse gas emissions at various stages of the food supply chain. Tracking food-related emissions along supply chains is key to systematically identify their sources, drivers and mitigation opportunities.

Variation in human telomere length has been well studied, but most previous studies have used adult telomere length. Here, the authors explore the genetic basis of telomere length in the placenta and find suggestive causal genes modulating human telomere length.

Plume-ridge interaction modulates plume-lithosphere interaction and leads to hotspot track deviations and paleolatitude offsets in multiple hotspot chains, according to 3D data assimilation models focused on the Hawaii-Emperor hotspot track.

Antibiotic resistance genes are common but not all are of high risk to human health. Here, the authors develop an omics-based framework for ranking genes by risk that incorporates level of enrichment in human associated environments, gene mobility, and host pathogenicity.

A study using paired ¹⁵N tracers shows atmospheric N deposited in oxidized form is more likely retained by trees, while the reduced form is retained in soil. The authors argue that this is a greater contribution of deposited N to the global forest C sink than previously reported.

Ataluren is the only nonsense suppressor drug currently approved for clinical use. Here, the authors determine where ataluren binds to the ribosome and how it inhibits termination at nonsense codons.

Here, the authors show that the gut commensal Parabacteroides distasonis alleviates insulin resistance via nicotinic acid-intestinal GPR109a axis activation, a process promoted by Dendrobium officinale polysaccharide.

Electrochemical conversion of carbon dioxide to methane can store intermittent renewable electricity in a staple of global energy. Here, the authors develop a moderator strategy to maintain the catalyst in a low coordination state, thereby enabling stable and selective electrochemical methanation.

The carbon and energy efficiencies of current CO₂/CO electrolysis systems are limited. Here the authors show that these metrics can be improved by controlling ion flows in the vicinity of a copper catalyst by the application of a covalent organic framework.

Brachyurans, or crabs, are of commercial and ecological importance, but limited genomic resources exist. Here the authors present a chromosome-level genome and expression data for the Chinese mitten crab, to shed light on the biology of this group.

The two-dimensional electron gases that form at LaAlO₃/SrTiO₃ heterostructure interfaces feature strong spin-orbit interactions, leading to proposed spintronic applications. Lin et al. show that the design of asymmetric heterostructures enables the Rashba spin-orbit interaction to be tuned between two regimes.

The integration of epitaxial complex oxides on semiconductor and flexible substrates is required but challenging. Here, the authors report the highly heterogeneous epitaxy of transferrable BaTiO_3-δ membrane with enhanced flexoelectricity on Ge (011).

Conventional alkaline and neutral CO₂-to-CH₄ systems suffer carbon loss, and recovering the lost carbon requires input energy exceeding the heating value of CH₄. Here, the authors report a chelating strategy to obtain Cu-N/O single sites decorated Cu clusters, which enables energy- and carbon-efficient CH₄ electroproduction in an acidic system.

The effects of Schwann cells on the neuro-stroma niche in pancreatic ductal adenocarcinoma (PDAC) remain to be explored. Here, single-cell RNA-sequencing and spatial transcriptome analysis of PDAC tissues reveal that Schwann cells induce malignant subtypes of tumour cells and cancer associated fibroblasts.

Saccharomyces cerevisiae can be engineered to slowly use methanol; however, a co-carbon source is usually required to support its growth. Now, a Saccharomyces cerevisiae strain that can use methanol as the sole carbon source for growth, and produce value-added bioproducts, is developed.

During the activation and migration of T cells volume changes occur in response to osmolality cues which is not fully understood. Here the authors characterize the function of volume regulated ion channels in T cells and show that these channels regulate TCR sensitivity, thymic selection and TCR repertoire.

Converting solar energy to hydrogen fuel requires light-absorbers that well-match the wavelengths of incoming sunlight. Here, authors prepare a broadband visible-light-absorbing molecular complex that efficiently produces hydrogen from water.

Molecular potentiometers that can indicate displacement-conductance relationship, and predict and control molecular conductance are of significant importance but rarely developed. Here, the authors design a robust single-molecule potentiometers based on helical structures and give insight in fundamental understanding of charge transport in higher-order helical molecules.

Temperature and pressure are typically dependent parameters in hydrothermal processes. Here, authors devise a hydrothermal system that allows independent control of these parameters and realize low-temperature fast synthesis of carbon sub-micron spheres directly from cellulose at higher pressure.

Smoking-associated DNA methylation changes in whole blood have been reported by many EWAS. Here, the authors use a cell-type deconvolution algorithm to identify cell-type specific DNA methylation signals in seven EWAS, identifying lineage-specific smoking-associated DNA methylation changes.