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Antibodies targeting the neuraminidase active site inhibit influenza H3N2 viruses with an S245N glycosylation site

Antibodies that broadly inhibit influenza virus neuraminidase by binding to its active site could be therapeutic candidates, but circulating viruses have acquired a glycosylation site in that region. Here, the authors show that, while the S245N glycosylation site affects binding of tested monoclonal antibodies, protective activity in a mouse model is maintained.

Daniel Stadlbauer
Meagan McMahon
Florian Krammer
ResearchOpen Access21 Dec 2022
Nature Communications

Volume: 13, P: 1-8
Development of a pentavalent broadly protective nucleoside-modified mRNA vaccine against influenza B viruses

The public health concern caused by influenza B virus is often overlooked, yet represents a significant global burden. Here, the authors evaluate the cellular and humoral immune responses of multivalent vaccine candidates, based on the lipid nanoparticle-encapsulated nucleoside-modified mRNA platform, and demonstrate protection of mice from challenge with a broad panel of influenza B viruses.

Norbert Pardi
Juan Manuel Carreño
Meagan McMahon
ResearchOpen Access09 Aug 2022
Nature Communications

Volume: 13, P: 1-14
Pre-existing immunity and vaccine history determine hemagglutinin-specific CD4 T cell and IgG response following seasonal influenza vaccination

Understanding individual variations in the response to seasonal influenza vaccines has broad implications from basic immunology to public health. Here authors show that influenza hemagglutinin-specific T and B cell responses are determined by the pre-vaccination immune phenotype and vaccination history of recipients.

Katharina Wild
Maike Smits
Tobias Boettler
ResearchOpen Access18 Nov 2021
Nature Communications

Volume: 12, P: 1-15
Functionality of the putative surface glycoproteins of the Wuhan spiny eel influenza virus

The recently identified Wuhan spiny eel influenza virus (WSEIV) sequence is more closely related to influenza B than A viruses. Here, the authors functionally characterize the putative surface glycoproteins of WSEIV and show that its NA-like protein has sialidase activity and its HA-like protein binds monosialic ganglioside 2.

Guha Asthagiri Arunkumar
Disha Bhavsar
Florian Krammer
ResearchOpen Access25 Oct 2021
Nature Communications

Volume: 12, P: 1-12
The neuraminidase of A(H3N2) influenza viruses circulating since 2016 is antigenically distinct from the A/Hong Kong/4801/2014 vaccine strain

The neuraminidase antigenicity of the circulating influenza A(H3N2) viruses differs from that of a recent A(H3N2) vaccine virus due to three amino acid substitutions, two of which introduce an N-linked glycosylation site that significantly reduces the binding of neuraminidase by antibodies.

Hongquan Wan
Jin Gao
Zhiping Ye
Research12 Aug 2019
Nature Microbiology

Volume: 4, P: 2216-2225
Broadly neutralizing antibodies target a haemagglutinin anchor epitope

A distinct class of broadly neutralizing antibodies to the influenza virus target a membrane-proximal anchor epitope of the haemagglutinin stalk ___domain.

Jenna J. Guthmiller
Julianna Han
Patrick C. Wilson
ResearchOpen Access23 Dec 2021
Nature

Volume: 602, P: 314-320
A chimeric hemagglutinin-based universal influenza virus vaccine approach induces broad and long-lasting immunity in a randomized, placebo-controlled phase I trial

New influenza virus vaccines tested in humans elicit broadly cross-reactive antibodies that bind the stalk of the viral hemagglutinin protein and may serve as templates to design a universal influenza vaccine.

Raffael Nachbagauer
Jodi Feser
Florian Krammer
Research07 Dec 2020
Nature Medicine

Volume: 27, P: 106-114
Human germinal centres engage memory and naive B cells after influenza vaccination

The human germinal centre response to influenza virus vaccination is fuelled by the continued recruitment of naive B cells as well as pre-existing memory B cells.

Jackson S. Turner
Julian Q. Zhou
Ali H. Ellebedy
Research31 Aug 2020
Nature

Volume: 586, P: 127-132
A serological assay to detect SARS-CoV-2 seroconversion in humans

Development of an enzyme-linked immunosorbent assay to detect antibodies to the SARS-CoV-2 spike protein in human sera and plasma.

Fatima Amanat
Daniel Stadlbauer
Florian Krammer
Research12 May 2020
Nature Medicine

Volume: 26, P: 1033-1036
A CpG 1018 adjuvanted neuraminidase vaccine provides robust protection from influenza virus challenge in mice

Shirin Strohmeier
Fatima Amanat
Florian Krammer
ResearchOpen Access22 Jul 2022
npj Vaccines

Volume: 7, P: 1-13
The antibody landscapes following AS03 and MF59 adjuvanted H5N1 vaccination

Johannes B. Goll
Aarti Jain
Philip L. Felgner
ResearchOpen Access30 Aug 2022
npj Vaccines

Volume: 7, P: 1-11
Magnitude and breadth of antibody cross-reactivity induced by recombinant influenza hemagglutinin trimer vaccine is enhanced by combination adjuvants

Jenny E. Hernandez-Davies
Emmanuel P. Dollinger
D. Huw Davies
ResearchOpen Access02 Jun 2022
Scientific Reports

Volume: 12, P: 1-20
AS03-adjuvanted H7N9 inactivated split virion vaccines induce cross-reactive and protective responses in ferrets

Daniel Stadlbauer
Leon de Waal
Corey P. Mallett
ResearchOpen Access19 Mar 2021
npj Vaccines

Volume: 6, P: 1-10

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