Nature Search

RIOK1 phase separation restricts PTEN translation via stress granules activating tumor growth in hepatocellular carcinoma

Meng et al. demonstrate that RIOK1 phase separation leads to PTEN mRNA sequestration and pentose pathway activation resolving cellular stress in hepatocellular carcinoma. Targeting RIOK1 enhances response to tyrosine kinase inhibitors.

Fanzheng Meng
Hairui Li
Lianxin Liu
Research04 Jun 2025
Nature Cancer

P: 1-19
Machine learning-based extrachromosomal DNA identification in large-scale cohorts reveals its clinical implications in cancer

‘Extrachromosomal DNA has been previously linked to tumour progression and heterogeneity, but its potential as a cancer biomarker has not been fully explored. Here, the authors develop a computational framework to refine genomic subtypes and predict response to immunotherapy in gastrointestinal cancer.

Shixiang Wang
Chen-Yi Wu
Qi Zhao
ResearchOpen Access19 Feb 2024
Nature Communications

Volume: 15, P: 1-17
Single-cell analysis of somatic mutations in human bronchial epithelial cells in relation to aging and smoking

Single-cell whole-genome sequencing of proximal bronchial basal cells shows that somatic mutations accumulate with age and at a higher level in smokers compared to never-smokers. Mutation frequencies increased with smoking dose but then plateaued, suggesting intrinsic mechanisms to limit mutation burden.

Zhenqiu Huang
Shixiang Sun
Jan Vijg
Research11 Apr 2022
Nature Genetics

Volume: 54, P: 492-498
Facilitating integrative and personalized oncology omics analysis with UCSCXenaShiny

UCSCXenaShiny integrates multidimensional data for robust and personalized pan-cancer analysis pipelines, enabling in-depth cancer data exploration in diverse scenarios.

Shensuo Li
Yuzhong Peng
Shixiang Wang
ResearchOpen Access28 Sept 2024
Communications Biology

Volume: 7, P: 1-9
Predictive value of inflammation and nutritional index in immunotherapy for stage IV non-small cell lung cancer and model construction

Wenqian Lei
Wei Wang
Weirong Yao
ResearchOpen Access30 Jul 2024
Scientific Reports

Volume: 14, P: 1-11
An all-optical multidirectional mechano-sensor inspired by biologically mechano-sensitive hair sensilla

Hair-like sensilla are evolved widely in organisms that perceive mechanical signals. Here, the authors report an all-optical mechano-sensor that can detect the real-time, directional displacement and force at several nm and μN levels.

Yuxiang Li
Zhihe Guo
Xiang Wu
ResearchOpen Access04 Apr 2024
Nature Communications

Volume: 15, P: 1-11
Cassava genome from a wild ancestor to cultivated varieties

Cassava is a major source of food in tropical and subtropical regions. Here the authors sequence the genomes of wild and domesticated cassava varieties and identify genes that have been selected for and against during the evolution and domestication of this economically important crop.

Wenquan Wang
Binxiao Feng
Ming Peng
ResearchOpen Access10 Oct 2014
Nature Communications

Volume: 5, P: 1-9
Two-step phase-shifting SPIDER

Shuiqin Zheng
Yi Cai
Shixiang Xu
ResearchOpen Access26 Sept 2016
Scientific Reports

Volume: 6, P: 1-6
Elevated acute phase proteins reflect peripheral inflammation and disease severity in patients with amyotrophic lateral sclerosis

David R. Beers
Weihua Zhao
Stanley H. Appel
ResearchOpen Access17 Sept 2020
Scientific Reports

Volume: 10, P: 1-17
APOBEC3B and APOBEC mutational signature as potential predictive markers for immunotherapy response in non-small cell lung cancer

Shixiang Wang
Mingming Jia
Xue-Song Liu
ResearchOpen Access26 Apr 2018
Oncogene

Volume: 37, P: 3924-3936
A multi-source information fusion approach in tunnel collapse risk analysis based on improved Dempster–Shafer evidence theory

Bo Wu
Weixing Qiu
Shixiang Xu
ResearchOpen Access07 Mar 2022
Scientific Reports

Volume: 12, P: 1-17
IFRD1 promotes tumor cells “low-cost” survival under glutamine starvation via inhibiting histone H1.0 nucleophagy

Yabin Huang
Fanzheng Meng
Lianxin Liu
ResearchOpen Access28 May 2024
Cell Discovery

Volume: 10, P: 1-21

Search

Filter By:

Search

Quick links