We present a novel biodegradable cancer therapeutic system based on DNAzyme nanoflowers for targeted dual gene silencing. The therapeutic system was constructed by copying rolling circle amplification template to produce long single-stranded DNAs with cell targeting and dual gene silencing capability. The structure of the nanoflowers collapsed at acidic pH due to decomposition of the co-assembled magnesium pyrophosphate, generating Mg2+ ions which act as cofactors for the DNAzymes and increase their ability to recognize and cleave target mRNAs. Considering its enhanced therapeutic effect and biocompatibility, this platform is expected to be of great interest for clinical treatment of cancers.
- Yi Jin
- Zhenhua Li
- Jinchao Zhang
