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Showing 1–4 of 4 results
Advanced filters: Author: Shravan Thaploo Clear advanced filters

  • HIV-infected memory CD4 T cells under antiretroviral therapy are a distinctive population of cells with transcriptomic patterns that favour HIV silencing, cell survival and cell proliferation.

    • Iain C. Clark
    • Prakriti Mudvari
    • Eli A. Boritz
    ResearchOpen Access
    Nature
    Volume: 614, P: 318-325

  • The pathogenic function of XBP1-expressing astrocytes in experimental autoimmune encephalomyelitis and multiple sclerosis have been studied using FIND-seq, a new method combining microfluidics cytometry, PCR-based detection of nucleic acids and cell sorting for in-depth single-cell transcriptomics analyses of rare cells.

    • Iain C. Clark
    • Michael A. Wheeler
    • Adam R. Abate
    Research
    Nature
    Volume: 614, P: 326-333

  • Single-cell RNA sequencing of cells from humans with multiple sclerosis and mice with a model of the disease identifies a population of disease-promoting astrocytes in which anti-oxidant and anti-inflammatory proteins are suppressed.

    • Michael A. Wheeler
    • Iain C. Clark
    • Francisco J. Quintana
    Research
    Nature
    Volume: 578, P: 593-599

  • FIND-seq is a nucleic acid cytometry platform capable of isolating rare cells on the basis of RNA or DNA markers. This protocol outlines the molecular and microfluidic steps to perform FIND-seq, followed by bulk or single-cell transcriptomic analysis.

    • Seung Won Shin
    • Prakriti Mudvari
    • Iain C. Clark
    Protocols
    Nature Protocols
    Volume: 19, P: 3191-3218