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Electrocatalyzed direct arene alkenylations without directing groups for selective late-stage drug diversification

Electrochemistry has emerged as an increasingly viable tool in molecular synthesis. Here the authors realize electrocatalyzed C−H activations, with the aid of data science and artificial intelligence, towards selective alkenylations for late-stage drug diversifications.

Zhipeng Lin
Uttam Dhawa
Lutz Ackermann
ResearchOpen Access15 Jul 2023
Nature Communications

Volume: 14, P: 1-8
Data-driven design of new chiral carboxylic acid for construction of indoles with C-central and C–N axial chirality via cobalt catalysis

The design of efficient and selective catalysts is a formidable challenge in chemical science. Here the authors design a data-driven workflow to achieve the digitalized knowledge transfer between the synthetically relevant transformations, which was demonstrated in the prediction of chiral carboxylic acid co-catalyst for the cobalt-catalyzed asymmetric C–H alkylation of indoles.

Zi-Jing Zhang
Shu-Wen Li
Lutz Ackermann
ResearchOpen Access31 May 2023
Nature Communications

Volume: 14, P: 1-9
Development and Validation of a Risk Scoring System for Cephamycin-Associated Hemorrhagic Events

Tong-Ling Chien
Fei-Yuan Hsiao
Shu-Wen Lin
ResearchOpen Access09 Sept 2019
Scientific Reports

Volume: 9, P: 1-8
Identification of Licoflavone C as a cap-dependent endonuclease inhibitor against severe fever with thrombocytopenia syndrome virus

Xiao Gao
Xiao-xue He
Xiao-yan Pan
Research01 Apr 2025
Acta Pharmacologica Sinica

P: 1-14
Response of mesenchymal stem cells to shear stress in tissue-engineered vascular grafts

Jian-de Dong
Yong-quan Gu
Jian Zhang
Research05 May 2009
Acta Pharmacologica Sinica

Volume: 30, P: 530-536
Author Correction: Infectious intestinal diseases elevate neurodegenerative disease risk based on a nationwide population-based cohort study

Fang-Chin Hsu
Tzu-Hsuan Weng
Wu-Chien Chien
Amendments and CorrectionsOpen Access21 Feb 2025
Scientific Reports

Volume: 15, P: 1
PSMA2 promotes chemo- and radioresistance of oral squamous cell carcinoma by modulating mitophagy pathway

Chun-I Wang
Cheng-Yi Chen
Kai-Ping Chang
ResearchOpen Access10 Jan 2025
Cell Death Discovery

Volume: 11, P: 1-12
Infectious intestinal diseases elevate neurodegenerative disease risk based on a nationwide population-based cohort study

Fang-Chin Hsu
Tzu-Hsuan Weng
Wu-Chien Chien
ResearchOpen Access28 Dec 2024
Scientific Reports

Volume: 14, P: 1-13
A small molecule compound targeting hemagglutinin inhibits influenza A virus and exhibits broad-spectrum antiviral activity

Yin-yan Li
Guo-dong Liang
Jie Yang
Research10 Jul 2024
Acta Pharmacologica Sinica

Volume: 45, P: 2380-2393
White spot syndrome virus (WSSV) modulates lipid metabolism in white shrimp

Investigation into the lipid metabolism shifts occurring in shrimp infected with white spot syndrome virus provides insight into how this virus modulates host metabolism in a way that creates a favorable environment for its replication.

Yen Siong Ng
Cheng-Shun Cheng
Han-Ching Wang
ResearchOpen Access20 May 2023
Communications Biology

Volume: 6, P: 1-11
[1,2,4]Triazolo[1,5-a]pyrimidine derivative (Mol-5) is a new NS5-RdRp inhibitor of DENV2 proliferation and DENV2-induced inflammation

Yi-hong Wan
Wen-yu Wu
Xin-gang Yao
Research15 Nov 2019
Acta Pharmacologica Sinica

Volume: 41, P: 706-718
Interleukin-37 promotes colitis-associated carcinogenesis via SIGIRR-mediated cytotoxic T cells dysfunction

Zhen Wang
Fan-lian Zeng
Jiong Li
ResearchOpen Access20 Jan 2022
Signal Transduction and Targeted Therapy

Volume: 7, P: 1-17
KIF2A regulates the spindle assembly and the metaphase I-anaphase I transition in mouse oocyte

Ming-Huang Chen
Yu Liu
Hai-Long Wang
ResearchOpen Access19 Dec 2016
Scientific Reports

Volume: 6, P: 1-12
DrugRep: an automatic virtual screening server for drug repurposing

Jian-hong Gan
Ji-xiang Liu
Yang Cao
Research10 Oct 2022
Acta Pharmacologica Sinica

Volume: 44, P: 888-896
TRPV4 channel is involved in HSV-2 infection in human vaginal epithelial cells through triggering Ca²⁺ oscillation

Ping Jiang
Song-shan Li
Shu-wen Liu
Research23 Sept 2022
Acta Pharmacologica Sinica

Volume: 44, P: 811-821
Mechanism of Interleukin-4 Reducing Lipid Deposit by Regulating Hormone-Sensitive Lipase

Ming-Yuh Shiau
Pei-Hua Chuang
Yih-Hsin Chang
ResearchOpen Access19 Aug 2019
Scientific Reports

Volume: 9, P: 1-11
Resveratrol treatment reveals a novel role for HMGB1 in regulation of the type 1 interferon response in dengue virus infection

Nurhafiza Zainal
Chih-Peng Chang
Yee-Shin Lin
ResearchOpen Access20 Feb 2017
Scientific Reports

Volume: 7, P: 1-12
Liver injury caused by antibodies against dengue virus nonstructural protein 1 in a murine model

Chiou-Feng Lin
Shu-Wen Wan
Yee-Shin Lin
Research04 Aug 2008
Laboratory Investigation

Volume: 88, P: 1079-1089

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