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AIM2 promotes excitatory glutamate receptor expression by inhibiting STING and contributes to bone cancer pain in male mice

Linhan Wang
Xueqin Xu
Changbin Ke
ResearchOpen Access30 Dec 2024
Scientific Reports

Volume: 14, P: 1-15
Downregulation of Roundabout guidance receptor 2 suppresses hepatocellular carcinoma progression by interacting with Y-box binding protein 1

Ting Liu
Congjie Zhai
Jia Wang
ResearchOpen Access31 Jan 2024
Scientific Reports

Volume: 14, P: 1-12
Metabolic regulation of cytoskeleton functions by HDAC6-catalyzed α-tubulin lactylation

The mechanisms regulating protein lactylation, a post-translational modification, are not fully understood. Here, the authors discover that Histone deacetylase 6 (HDAC6) acts as the primary lactyltransferase for α-tubulin, regulating microtubule dynamics.

Shuangshuang Sun
Zhe Xu
Lei Li
ResearchOpen Access27 Sept 2024
Nature Communications

Volume: 15, P: 1-14
tRF-33-P4R8YP9LON4VDP inhibits gastric cancer progression via modulating STAT3 signaling pathway in an AGO2-dependent manner

Shuangshuang Zhang
Yeqi Gu
Junming Guo
Research23 May 2024
Oncogene

Volume: 43, P: 2160-2171
Logistic analysis of delayed reporting of emergency blood potassium and comparison of improved outcomes

Jian Zhang
Shuangshuang Lv
Xiaxuan Hu
ResearchOpen Access13 Mar 2024
Scientific Reports

Volume: 14, P: 1-9
Pollen tube emergence is mediated by ovary-expressed ALCATRAZ in cucumber

Pollen tube growth is guided towards ovules. Here the authors show that a bHLH transcriptional factor CsALC functions in pollen tube emergence towards ovules to regulate female fertility in cucumber and promotes the expression of two rapid alkalinization factors CsRALF4/19 in the ovary.

Zhihua Cheng
Xiaofeng Liu
Xiaolan Zhang
ResearchOpen Access17 Jan 2023
Nature Communications

Volume: 14, P: 1-15
Salmonella Typhimurium reprograms macrophage metabolism via T3SS effector SopE2 to promote intracellular replication and virulence

Salmonella Typhimurium establishes systemic infection by replicating in host macrophages. Here, Jiang et al. show that infected macrophages exhibit upregulated glycolysis and decreased serine synthesis, leading to accumulation of glycolytic intermediates that promote intracellular replication and virulence of S. Typhimurium.

Lingyan Jiang
Peisheng Wang
Lei Wang
ResearchOpen Access09 Feb 2021
Nature Communications

Volume: 12, P: 1-18
NAD⁺ exhaustion by CD38 upregulation contributes to blood pressure elevation and vascular damage in hypertension

Yumin Qiu
Shiyue Xu
Jun Tao
ResearchOpen Access18 Sept 2023
Signal Transduction and Targeted Therapy

Volume: 8, P: 1-14
Human pluripotent stem-cell-derived islets ameliorate diabetes in non-human primates

Improved glycemic control after transplantation of human pluripotent stem-cell-derived islets for diabetes treatment in non-human primates.

Yuanyuan Du
Zhen Liang
Hongkui Deng
Research03 Feb 2022
Nature Medicine

Volume: 28, P: 272-282
Implantation underneath the abdominal anterior rectus sheath enables effective and functional engraftment of stem-cell-derived islets

A new transplantation site in the abdomen, the subanterior rectus sheath, is shown to allow for functional maturation of stem-cell-derived islet cells and improved glycemic control in a proof-of-principle study involving four nonhuman primates.

Zhen Liang
Dong Sun
Hongkui Deng
Research09 Jan 2023
Nature Metabolism

Volume: 5, P: 29-40
UF-5000 urinary erythrocyte parameters versus urinary aberrant erythrocytes and acanthocytes for diagnosing IgA glomerular hematuria

Shuangshuang Lv
Yi Fang
Dongmei Zhang
ResearchOpen Access07 Jan 2025
Scientific Reports

Volume: 15, P: 1-13
Deep learning-based polygenic risk analysis for Alzheimer’s disease prediction

Zhou et al. utilise deep learning to improve polygenic risk analysis for Alzheimer’s disease. Their computational approach outperforms existing statistical methods and helps to identify potential biological mechanisms of Alzheimer’s disease risk.

Xiaopu Zhou
Yu Chen
Nancy Y. Ip
ResearchOpen Access06 Apr 2023
Communications Medicine

Volume: 3, P: 1-20
A draft genome for Spatholobus suberectus

Shuangshuang Qin
Lingqing Wu
Zhongyi Zhang
ResearchOpen Access04 Jul 2019
Scientific Data

Volume: 6, P: 1-9

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AIM2 promotes excitatory glutamate receptor expression by inhibiting STING and contributes to bone cancer pain in male mice

Downregulation of Roundabout guidance receptor 2 suppresses hepatocellular carcinoma progression by interacting with Y-box binding protein 1

Metabolic regulation of cytoskeleton functions by HDAC6-catalyzed α-tubulin lactylation

tRF-33-P4R8YP9LON4VDP inhibits gastric cancer progression via modulating STAT3 signaling pathway in an AGO2-dependent manner

Logistic analysis of delayed reporting of emergency blood potassium and comparison of improved outcomes

Pollen tube emergence is mediated by ovary-expressed ALCATRAZ in cucumber

Salmonella Typhimurium reprograms macrophage metabolism via T3SS effector SopE2 to promote intracellular replication and virulence

NAD⁺ exhaustion by CD38 upregulation contributes to blood pressure elevation and vascular damage in hypertension

Human pluripotent stem-cell-derived islets ameliorate diabetes in non-human primates

Implantation underneath the abdominal anterior rectus sheath enables effective and functional engraftment of stem-cell-derived islets

UF-5000 urinary erythrocyte parameters versus urinary aberrant erythrocytes and acanthocytes for diagnosing IgA glomerular hematuria

Deep learning-based polygenic risk analysis for Alzheimer’s disease prediction

A draft genome for Spatholobus suberectus

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