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Publisher Correction: Combining an artificial metathase with a fatty acid decarboxylase in a whole cell for cycloalkene synthesis

Zhi Zou
Shuke Wu
Thomas R. Ward
Amendments and Corrections05 Aug 2024
Nature Synthesis

Volume: 3, P: 1184
Direct asymmetric synthesis of β-branched aromatic α-amino acids using engineered phenylalanine ammonia lyases

β-Branched aromatic α-amino acids are valuable building blocks in natural products and pharmaceutically active compounds, but their synthesis is challenging due to the presence of two stereocenters. Here, the authors design phenylalanine ammonia lyases variants for the direct asymmetric synthesis of β-branched aromatic α-amino acids and reveal the reasons for enzyme’s inability to accept β-methyl cinnamic acid.

Chenghai Sun
Gen Lu
Uwe T. Bornscheuer
ResearchOpen Access26 Sept 2024
Nature Communications

Volume: 15, P: 1-13
A growth selection system for the directed evolution of amine-forming or converting enzymes

Fast screening of enzymes is key for directed evolution of industrial biocatalysts. Here, the authors report a simple, high-throughput, and low-equipment-dependent growth selection system for engineering three enzymes for synthesis of chiral amines.

Shuke Wu
Chao Xiang
Uwe T. Bornscheuer
ResearchOpen Access03 Dec 2022
Nature Communications

Volume: 13, P: 1-10
SLC17A1/3 transporters mediate renal excretion of Lac-Phe in mice and humans

The lactate metabolite N-lactoyl-phenylalanine (Lac-Phe) plays a role in suppressing food intake and body weight. Here, the authors identify kidney transporters responsible for the renal excretion of Lac-Phe. This discovery highlights a pathway for Lac-Phe regulation in mice and humans.

Veronica L. Li
Shuke Xiao
Jonathan Z. Long
ResearchOpen Access12 Aug 2024
Nature Communications

Volume: 15, P: 1-10
PTER is a N-acetyltaurine hydrolase that regulates feeding and obesity

The orphan enzyme phosphotriesterase-related (PTER) is identified as a mammalian N-acetyltaurine hydrolase that has roles in regulating body weight and energy balance.

Wei Wei
Xuchao Lyu
Jonathan Z. Long
ResearchOpen Access07 Aug 2024
Nature

Volume: 633, P: 182-188
Combining an artificial metathase with a fatty acid decarboxylase in a whole cell for cycloalkene synthesis

Artificial metalloenzymes are useful catalysts in synthesis, but their use in cells is a challenge. Now, the development of an engineered whole-cell enzymatic cascade, which converts glucose-derived fatty diacids into cycloalkenes, is reported. The cascade process combines a decarboxylase with an artificial metalloenzyme that catalyses an abiotic olefin metathesis reaction.

Zhi Zou
Shuke Wu
Thomas R. Ward
Research27 Jun 2024
Nature Synthesis

Volume: 3, P: 1113-1123
Highly regio- and enantioselective multiple oxy- and amino-functionalizations of alkenes by modular cascade biocatalysis

Biocatalysis can perform highly selective multi-step synthesis in one pot, but with a limited range of non-natural reactions and products. Here, the authors report regio- and enantioselective bio-cascades, able to convert styrenes into a number of nitrogen and oxygen containing chiral molecules.

Shuke Wu
Yi Zhou
Zhi Li
ResearchOpen Access14 Jun 2016
Nature Communications

Volume: 7, P: 1-13
Chemo-enzymatic cascades to produce cycloalkenes from bio-based resources

Cycloalkenes are bulk petrochemicals that are currently obtained from fossil fuels. Here, the authors developed multi enzyme pathways in combination with a Ru-catalyzed metathesis reaction for the one-pot production of cyclopentene, cyclohexene, and cycloheptene from olive oil-derived intermediates.

Shuke Wu
Yi Zhou
Thomas R. Ward
ResearchOpen Access07 Nov 2019
Nature Communications

Volume: 10, P: 1-10
Programming a Pavlovian-like conditioning circuit in Escherichia coli

Synthetic gene circuits can be programmed in living cells to perform diverse cellular functions. Here, the authors program a genetic circuit that performs a Pavlovian-like learning and recall function in E. coli, and demonstrate the dynamic nature of this conditioning process at a population level.

Haoqian Zhang
Min Lin
Qi Ouyang
Research17 Jan 2014
Nature Communications

Volume: 5, P: 1-10
Lac-Phe mediates the effects of metformin on food intake and body weight

Metformin is shown to trigger production and release of Lac-Phe from gut epithelial cells, which is required for its effects on food intake and loss of body weight.

Shuke Xiao
Veronica L. Li
Jonathan Z. Long
Research18 Mar 2024
Nature Metabolism

Volume: 6, P: 659-669

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Publisher Correction: Combining an artificial metathase with a fatty acid decarboxylase in a whole cell for cycloalkene synthesis

Direct asymmetric synthesis of β-branched aromatic α-amino acids using engineered phenylalanine ammonia lyases

A growth selection system for the directed evolution of amine-forming or converting enzymes

SLC17A1/3 transporters mediate renal excretion of Lac-Phe in mice and humans

PTER is a N-acetyltaurine hydrolase that regulates feeding and obesity

Combining an artificial metathase with a fatty acid decarboxylase in a whole cell for cycloalkene synthesis

Highly regio- and enantioselective multiple oxy- and amino-functionalizations of alkenes by modular cascade biocatalysis

Chemo-enzymatic cascades to produce cycloalkenes from bio-based resources

Programming a Pavlovian-like conditioning circuit in Escherichia coli

Lac-Phe mediates the effects of metformin on food intake and body weight

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