Senescent cells and their production of inflammatory cytokines (senescence-associated secretory phenotype) affects aging and disease, including cancer. Zhang et al. report that epigenomic remodeling by KDM4 controls the senescence-associated secretory phenotype, and KDM4 expression by stromal cells of the tumor microenvironment promotes prostate cancer.
- Boyi Zhang
- Qilai Long
- Yu Sun
