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A fuzzy sequencer can exceed the current limit of information efficiency of DNA sequencers for resequencing applications.

The efficiency of pure sulfide kesterite solar cells is limited by deep-level defects. Wu et al. develop a heat treatment in an oxygen-rich environment to suppress sulfur vacancies, achieving an 11.51% certified efficiency.

Succinylation, a posttranslational modification on lysine residues, is involved in tumor progression. Here, authors show that PDHA1 K83 succinylation is involved in cholangiocarcinoma tumorigenesis through regulation of macrophage antigen presentation in the tumor microenvironment

Liver transplantation can be an effective treatment for hepatocellular carcinoma, however, outcomes can be variable. Here, the authors use multi-omics to develop subgroups and identify a CAF-related classification.

Human leucocyte antigens are important in the adaptive immune response. Here, the authors use data from the UK Biobank linked to electronic health records to investigate the association between genetic variation in HLA alleles and antibody responses to SARS-CoV-2 vaccination and breakthrough COVID-19 outcomes.

This paper introduces an oxide-dispersion-strengthening strategy that enables sub-100 μm. high-precision additive manufacturing of copper, thereby addressing the limitations of current processes for microscale technologies.

The annual microbial N₂O flux is 2.9 Tg/yr from the ocean, with ODZs accounting for more than half. Geographically, AOA are the most widely distributed contributors, while heterotrophic denitrification mainly occurs in ODZs and contributes the most.

Protein kinase R-like endoplasmic reticulum kinase-phosphorylated adenylosuccinate lyase (ADSL) binds to Beclin1 upon lipid deprivation. ADSL-produced fumarate increases Beclin1 K117 dimethylation by inhibiting lysine demethylase 8 activity, resulting in disrupted binding of BCL-2 to Beclin1, enhanced autophagy and liver tumor growth.

Rare disease DEDSSH1-associated DPH1 mutations impair eEF2 diphthamide modification that leads to eEF2 as a transcriptional coactivator for p53 to enhance expression of the cell proliferation inhibitor p21, resulting in birth defects.

Electrocardiogram is crucial for cardiovascular disease prevention, diagnosis, and prognosis. Here, the authors present a motion-unrestricted dynamic electrocardiogram system utilizing skin-conformal, imperceptible electronics for long-term, comfortable, and accurate 12-lead monitoring.

Duan, Hu, Han, Lei, Wang et al. report that ADSL-mediated production of fumarate suppresses STING activation and impairs T cell and NK cell infiltration, thereby facilitating immune evasion in breast cancer.

The synthesis of vinylboronates and alkylboronates often suffers from step-tedious and poorly stereoselective procedures. Here, the authors report a bench-stable redox-active reagent for the radical difunctionalization of alkenes and alkynes affording fluorine-containing vinylboronates and alkylboronates.

The role of lactylation in non-histone proteins remains underexplored. Here, the authors investigate lactylation on ALDOA-K147 by proteomics, GCE, and biochemical assays, revealing its diverse regulatory effects on cellular processes, including metabolism, nuclear translocation and gene regulation.

Azahetereocycles represent promising scaffolds in drug discovery. Here, the authors report a Pd-catalyzed migratory cycloannulation strategy for efficient construction of a wide range of azahetereocycles from unactivated aliphatic alkenes.

Adult human hearts exhibit restricted regenerative ability, where cardiomyocyte loss leads to dysfunction, while neonatal hearts can regenerate, though the molecular mechanisms remain poorly understood. Here, the authors show that N-cadherin plays a crucial role in driving cardiomyocyte self-renewal by stabilizing β-catenin, representing a unique opportunity to promote cardiac regeneration and restore contractile function in the injured adult heart

A cascade reaction network has been created that can function in a manner that is superficially similar to the most basic steps of the vertebrate adaptive immune response. This reaction network uses DNA and enzymes as simple artificial analogues of the components of the acquired immune system.

Viral coat proteins are perceived by the RING1–IBR–RING2-type ubiquitin ligase, initiating the first step of the natural antiviral response in rice.

By constructing a graph-based grapevine pangenome reference (Grapepan v.1.0) and incorporating structural variations and phenotypic maps, the study investigates the genetic basis of agronomic traits, empowering grapevine genomic breeding.

The potential of oncolytic virus (OV) for cancer therapy is limited by the efficiency of immune response induced. Here the authors show that HSV-1-based OV is capable of triggering ZBP1-mediated PANoptosis resulting in effective tumor growth inhibition.

Our results show that unilateral partial adrenalectomy is not a good surgical option for the majority of lateralized PA patients. In clinically lateralized PA patients, no matter which group they are in the HISTALDO classification, they would benefit from unilateral total adrenalectomy.

Carbon monoxide emissions in Shanxi, China are up to seven times greater than existing datasets predict, especially over low emission areas, according to an inversion study using satellite data.

A non-volatile compute-in-memory macro that is based on spin-transfer torque magnetic random-access memory can offer secure access control, data protection, rapid response times and high energy efficiency for dot-product edge computing.

Pentafluorosulfanyl alcohols, compounds that serve as synthetically valuable building blocks, are difficult to prepare with current methodologies. Herein, the author report a single-step, metal-free, and photo-induced hydroxypentafluorosulfanylation of styrenes or α,β-unsaturated esters/amide for the synthesis of pentafluorosulfanyl alcohols.

The relevance of spliceosome core components in cancer is less understood. Here the authors show SmD2, a core component of the spliceosome machinery, is under acetylation-dependent regulation, which could be targeted to enhance sensitivity to PARP inhibitors in hepatocellular carcinoma.

A consensus cell type atlas for the fly brain provides both an intellectual framework and open-source toolchains for brain-scale comparative connectomics.

TLR7 has been shown to promote inflammatory autoimmunity. Here the authors investigate whether changes in RNA structure affect TLR signaling and show that a TLR7 binding lncRNA Lnc-Atg16l1 promotes development of autoimmunity in the mouse SLE model through enhancement of TLR7-MyD88 interactions.

Divacancy color centers in SiC are promising candidates for a spin-photon interface, but typically show charge-state instability under optical excitation. Here the authors show that modified divacancies created by a focused helium ion beam are robust against photoionization and have promising properties.

Yu Shi et al. show that the citric acid cycle metabolite α-ketoglutarate promotes cardiomyocyte proliferation during heart development and promotes heart regeneration after myocardial infarction.

Effective transport layers are essential to suppress non-radiative recombination losses. Here, the authors introduce phenylamino-functionalized ortho-carborane as an interfacial layer, and realise inverted perovskite solar cells with efficiency of over 23% and operational stability of T97 = 400 h.

Integrating multiple silicon waveguides with black phosphorus enables the realization of a variety of optoelectronic logic gates operating at 1.55 μm.

Investigating metabolic disturbances in coronary artery disease (CAD) may allow the identifications of new prognostic biomarkers. Here the authors perform a metabolomics study to highlight the shared and distinct metabolites characterizing risks of several cardiovascular events in CAD patients.

Organic nonlinear optical materials have potential in applications such as bioimaging, but tend to have low photoluminescent quantum yields and are prone to aggregation-caused quenching. Here, the authors report a host-guest approach for improving the luminescent properties of these materials.

Hydrological risks drive migration more than socioeconomic factors. Vulnerable groups often stay in high-risk areas or migrate nearby. The study reveals an S-shaped migration pattern influenced by settlement resilience and adaptability.

An efficient molecular nanojunction photocatalyst for hydrogen evolution is identified from a combinatorial molecular library, assisted by a materials acceleration platform, which is then scaled-up to the litre scale using flow synthesis.

Evolution of accretion disk and corona during outbursts in black hole binary systems is still unclear. Here, the authors show spectral analysis of MAXI J1820+070 and propose a scenario of a dynamical corona to explain the evolution of the reflection fraction observed by Insight-HXMT.

The formyl peptide receptor 2 (FPR2) is involved in the pathogenesis of Alzheimer’s disease. Structures of FPR2 bound to Aβ₄₂, humanin, or formyl peptides offer insight into Aβ₄₂ neurotoxicity, humanin neuroprotection, and FPR ligand selectivity

Tong et al. describe a super pangenome assembled from long-read sequences of 545 wild and domesticated silkworms. Naturally selected (diapause, aposemantic coloration) or artificially selected (silk yield and fineness) sets of genes are delineated.