Lim et al. find that osteoblast-specific deletion of IFT20 impairs osteoblast/osteocyte cell alignment and reduces bone mass. Their results further show that the mechanism underlying IFT20-associated bone ciliopathies involves defects in cell polarity caused by deficient Ceramide-PKCζ recruitment to cilia and reduced β-catenin signaling, which interferes with bone development.
- Jormay Lim
- Xinhua Li
- Shuying Yang
