This study demonstrates that ATF-3 plays a suppressive function in melanoma tumor progression via a significant decrease in expression in metastatic melanoma and correlation with tumor virulence. ATF-3 overexpression significantly inhibits cell growth, migration, and invasion in vitro, and abrogates tumor growth in a human melanoma xenograft mouse model in vivo.
- Tingjian Zu
- Diana Wang
- George F. Murphy