Nature Search

C/EBPδ expression in a BCR-ABL-positive cell line induces growth arrest and myeloid differentiation

Sigal Gery
Sakae Tanosaki
H Phillip Koeffler
Research10 Jan 2005
Oncogene

Volume: 24, P: 1589-1597
Reciprocal inhibition between TP63 and STAT1 regulates anti-tumor immune response through interferon-γ signaling in squamous cancer

TP63 is a master regulator transcription factor in squamous cell carcinomas (SCCs). Here the authors report that TP63 suppresses IFNγ signaling in SCC tumors and that its inhibition is associated with enhanced anti-tumor immunity and response to anti-PD1.

Yuan Jiang
Yueyuan Zheng
Yan-Yi Jiang
ResearchOpen Access20 Mar 2024
Nature Communications

Volume: 15, P: 1-18
Bromodomain and extraterminal proteins foster the core transcriptional regulatory programs and confer vulnerability in liposarcoma

Liposarcoma (LPS) is a rare cancer that can acquire resistance to chemotherapy. Here, the authors map super-enhancers in LPS, finding BET-protein dependent mechanisms that can be targeted by a BET protein degrader, which also can overcome acquired resistance to chemotherapy in LPS.

Ye Chen
Liang Xu
H. Phillip Koeffler
ResearchOpen Access22 Mar 2019
Nature Communications

Volume: 10, P: 1-14
Interplay and cooperation between SREBF1 and master transcription factors regulate lipid metabolism and tumor-promoting pathways in squamous cancer

The relevance and underlying molecular mechanisms of epigenetic regulation in squamous cell carcinomas (SCC) await further characterization. Here, the authors show a transcriptional regulatory loop involving SREBF1, TP63 and KLF5 driving tumourigenesis in SCC through fatty acid, ERBB and mTOR pathway regulation.

Li-Yan Li
Qian Yang
De-Chen Lin
ResearchOpen Access16 Jul 2021
Nature Communications

Volume: 12, P: 1-17
TMEFF1 and brain tumors

Sigal Gery
Dong Yin
H Phillip Koeffler
Research09 May 2003
Oncogene

Volume: 22, P: 2723-2727
TMEFF2 is an androgen-regulated gene exhibiting antiproliferative effects in prostate cancer cells

Sigal Gery
Charles L Sawyers
H Phillip Koeffler
Research09 Jul 2002
Oncogene

Volume: 21, P: 4739-4746
MNK1 and MNK2 enforce expression of E2F1, FOXM1, and WEE1 to drive soft tissue sarcoma

Xin-Yu Ke
Ye Chen
H. Phillip Koeffler
ResearchOpen Access09 Feb 2021
Oncogene

Volume: 40, P: 1851-1867
ARID1A and CEBPα cooperatively inhibit UCA1 transcription in breast cancer

Xiao Guo
Yin Zhang
H. Phillip Koeffler
Research06 Jul 2018
Oncogene

Volume: 37, P: 5939-5951

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