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Showing 1–11 of 11 results
Advanced filters: Author: Sihem Cheloufi Clear advanced filters

  • Cellular quiescence is a reversible dormant state that helps cells survive stress, support tissue regeneration, and promote longevity. Here, the authors show that blocking ribosomal RNA production by rapid depletion of RNase MRP induces a long-lasting quiescence-like state in human cells.

    • Yuan Liu
    • Shiyang He
    • Jernej Murn
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-16

  • Cell fate commitment involves transcription factor activity and changes in chromatin architecture. Here the authors show that CAF-1 maintains lineage fidelity by controlling chromatin accessibility at specific sites; suppressing CAF-1 triggers differentiation of myeloid stem and progenitor cells into a mixed lineage state.

    • Reuben Franklin
    • Yiming Guo
    • Sihem Cheloufi
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-17

  • Researchers have coaxed cultured embryonic stem cells to develop into eggs that then give rise to normal offspring. The discovery should help to decode the molecular basis of gamete formation and might lead to treatments for infertility.

    • Sihem Cheloufi
    • Konrad Hochedlinger
    News & Views
    Nature
    Volume: 491, P: 535-536

  • RNA interference screens were used to identify chromatin-associated factors that impede reprogramming of somatic cells into iPS cells; suppression of the chromatin assembly factor CAF-1 enhances the generation of iPS cells by rendering chromatin more accessible to pluripotency transcription factors.

    • Sihem Cheloufi
    • Ulrich Elling
    • Konrad Hochedlinger
    Research
    Nature
    Volume: 528, P: 218-224

  • Over evolutionary time genes can undergo duplication, and may accumulate mutations that render them non-functional pseudogenes, which are thought to be uninteresting. This study (and that of the group of Sasaki) shows that pseudogenes can in fact influence gene expression.

    • Oliver H. Tam
    • Alexei A. Aravin
    • Gregory J. Hannon
    Research
    Nature
    Volume: 453, P: 534-538

  • How RNA-binding proteins (RBPs) regulate gene expression via effectors of RNA processing is unclear. Here, the authors dissect the effector interface of an essential RBP, Unkempt, and investigate its contribution to translational control in cells.

    • Kriti Shah
    • Shiyang He
    • Jernej Murn
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-18

  • This Review surveys the known mechanisms of communication between RBPs and their effectors and their roles in reducing the complexity of RNA networks. The authors review the emerging roles of RBP–effector interactions in the control of RNA processing and regulation of biological outcomes, and their contribution to human health and disease.

    • Shiyang He
    • Eugene Valkov
    • Jernej Murn
    Reviews
    Nature Reviews Genetics
    Volume: 24, P: 276-294

  • MicroRNAs, which regulate gene expression, are transcribed as longer sequences that are processed to produce the mature form. Two nuclease enzymes, Drosha and Dicer, are known to act sequentially to trim the microRNA to size. Here, however, a subset of microRNAs that includes miR-451, important for erythropoiesis, is found to be processed independently of Dicer. Rather, the Argonaute protein — part of the complex that aligns microRNA and messenger RNA — carries out the secondary cleavage.

    • Sihem Cheloufi
    • Camila O. Dos Santos
    • Gregory J. Hannon
    Research
    Nature
    Volume: 465, P: 584-589