Nature Search

hpCasMINI: An engineered hypercompact CRISPR-Cas12f system with boosted gene editing activity

Although Cas12f proteins benefit from compact size for delivery, their gene-editing activity remains limited. By adding an N-terminal α-helix to Cas12f, we created hpCasMINI, hpOsCas12f1, and hpAsCas12f1 variants that show improved gene activation and DNA cleavage in mammalian cells and mice.

Shufeng Ma
Kaitong Liao
Zhili Rong
ResearchOpen Access29 May 2025
Nature Communications

Volume: 16, P: 1-14
Newly formed dust within the circumstellar environment of SN Ia-CSM 2018evt

By day 1,041 after explosion, SN Ia-CSM 2018evt had produced an estimated 0.01 solar masses of dust in the cold, dense shell behind the supernova ejecta–circumstellar medium interaction, ranking it as one of the most prolific dust-producing supernovae ever recorded.

Lingzhi 灵芝 Wang王
Maokai Hu
Xinghan Zhang
ResearchOpen Access09 Feb 2024
Nature Astronomy

Volume: 8, P: 504-519
Scalable ultrastrong MXene films with superior osteogenesis

Large-scale roll-to-roll-assisted blade coating is used in the production of scalable ultrastong MXene films with superior mechanical, electromagnetic shielding and bone regeneration properties.

Sijie Wan
Ying Chen
Qunfeng Cheng
Research30 Oct 2024
Nature

Volume: 634, P: 1103-1110
Vacancy-induced suppression of charge density wave order and its impact on magnetic order in kagome antiferromagnet FeGe

FeGe is an antiferromagnetic kagome metal with a rich magnetic and electronic phase diagram. Recently it was found that post-growth annealing of FeGe can suppress or induce charge density wave order depending on the annealing temperature. Here, Klemm, Siddique et al show the critical role that annealing induced Ge-vacancies and stacking faults play in the formation of charge density wave order in FeGe.

Mason L. Klemm
Saif Siddique
Pengcheng Dai
ResearchOpen Access07 Apr 2025
Nature Communications

Volume: 16, P: 1-12
A superlattice interface and S-scheme heterojunction for ultrafast charge separation and transfer in photocatalytic H₂ evolution

Limited charge separation is a major challenge in creating efficient semiconductor photocatalysis. This work introduces a superlattice interface and S-scheme heterojunction for ultrafast charge separation and transfer in photocatalytic H₂ evolution.

Sijie Wan
Wang Wang
Lianmeng Zhang
ResearchOpen Access07 Nov 2024
Nature Communications

Volume: 15, P: 1-14
Design of target specific peptide inhibitors using generative deep learning and molecular dynamics simulations

Here the authors report a computational approach which integrates deep learning and structural modelling to design target-specific peptides. They apply this to β-catenin and NF-κB essential modulator, resulting in improved binding, highlighting the efficacy of this strategy.

Sijie Chen
Tong Lin
Xiaolin Cheng
ResearchOpen Access21 Feb 2024
Nature Communications

Volume: 15, P: 1-20
Structural insights into the lipid and ligand regulation of serotonin receptors

Cryo-electron microscopy structures of three different serotonin receptors in complex with serotonin and other agonists provide insights into the role of lipids in regulating these receptors and the structural basis of ligand recognition.

Peiyu Xu
Sijie Huang
H. Eric Xu
Research24 Mar 2021
Nature

Volume: 592, P: 469-473
Cathepsin B-dependent glycolysis contributes to reduced renal uric acid excretion in hyperuricemia

Mechanistic insights reveal that cathepsin B dependent glycolysis regulates urate transporter expression, contributing to impaired renal uric acid excretion in hyperuricemia

Huagang Lin
Linjing Nie
Jing Xiao
ResearchOpen Access02 Jun 2025
Communications Biology

Volume: 8, P: 1-16
Structural identification of lysophosphatidylcholines as activating ligands for orphan receptor GPR119

The cryo-EM structures reveal orphan receptor GPR119 as the receptor for LPC. The structures with biochemical and functional data highlight evidence for LPC function in glucose regulation, and provide templates for drug design targeting GPR119.

Peiyu Xu
Sijie Huang
H. Eric Xu
Research15 Aug 2022
Nature Structural & Molecular Biology

Volume: 29, P: 863-870
Ultrastrong MXene films via the synergy of intercalating small flakes and interfacial bridging

Potential application of Titanium carbide MXene in wearable devices is limited by the formation of voids during assembly. Here, the authors demonstrate a synergistic densification strategy by intercalating small flakes and interfacial bridging to obtain high-performance MXene films.

Sijie Wan
Xiang Li
Qunfeng Cheng
ResearchOpen Access29 Nov 2022
Nature Communications

Volume: 13, P: 1-8
Chromosome-level scaffolding of haplotype-resolved assemblies using Hi-C data without reference genomes

This study uncovers key challenges in allele-aware genome scaffolding with Hi-C data. A reference-independent Hi-C scaffolder showing superior performance was developed to construct the haplotype-resolved genome of triploid Miscanthus × giganteus.

Xiaofei Zeng
Zili Yi
Guoan Chen
Research05 Aug 2024
Nature Plants

Volume: 10, P: 1184-1200
Room-temperature non-volatile optical manipulation of polar order in a charge density wave

Manipulating collective phenomena in solid-state platforms with optical means is an ongoing topic of interest in condensed matter physics. Here, the authors demonstrate all-optical room-temperature manipulation of electronic states in the charge-density-wave material EuTe₄.

Qiaomei Liu
Dong Wu
Nanlin Wang
ResearchOpen Access16 Oct 2024
Nature Communications

Volume: 15, P: 1-8
High-strength scalable graphene sheets by freezing stretch-induced alignment

Stretch-induced alignment of graphene sheets is frozen by sequential covalent and π–π bridging, leading to high in-plane isotropic strength of 1.55 GPa. The graphene sheets are fabricated at near room temperature and are scalable.

Sijie Wan
Ying Chen
Qunfeng Cheng
Research04 Feb 2021
Nature Materials

Volume: 20, P: 624-631
Publisher Correction: A Co₃O₄-CDots-C₃N₄ three component electrocatalyst design concept for efficient and tunable CO₂ reduction to syngas

Sijie Guo
Siqi Zhao
Zhenhui Kang
Amendments and CorrectionsOpen Access08 Feb 2018
Nature Communications

Volume: 9, P: 1
Microwave imaging of quasi-periodic pulsations at flare current sheet

Quasi-periodic pulsations (QPPs) are frequently detected in solar and stellar flares, but the underlying physical mechanisms are still to be ascertained. Here, the authors show microwave QPPs during a solar flare originating from quasi-periodic magnetic reconnection at the flare current sheet.

Yuankun Kou
Xin Cheng
Mingde Ding
ResearchOpen Access12 Dec 2022
Nature Communications

Volume: 13, P: 1-11
Ultrastable near-infrared perovskite light-emitting diodes

Near-infrared perovskite light-emitting diodes with extrapolated device lifespans on the scale of years are achieved by the use of a dipolar molecular stabilizer.

Bingbing Guo
Runchen Lai
Dawei Di
Research08 Aug 2022
Nature Photonics

Volume: 16, P: 637-643
A Co₃O₄-CDots-C₃N₄ three component electrocatalyst design concept for efficient and tunable CO₂ reduction to syngas

Simultaneous electrochemical reduction of CO₂ and H⁺/H₂O is an attractive renewable route to produce syngas mixtures. Here, the authors introduce a ternary Co₃O₄-CDots-C₃N₄ electrocatalyst that couples hydrogen evolution and CO₂ reduction catalysts and achieves cheap, stable and tunable production of syngas.

Sijie Guo
Siqi Zhao
Zhenhui Kang
ResearchOpen Access28 Nov 2017
Nature Communications

Volume: 8, P: 1-9
Long noncoding RNA AVAN promotes antiviral innate immunity by interacting with TRIM25 and enhancing the transcription of FOXO3a

Chengcai Lai
Lihui Liu
Penghui Yang
Research14 May 2021
Cell Death & Differentiation

Volume: 28, P: 2900-2915
A Cullin 5-based complex serves as an essential modulator of ORF9b stability in SARS-CoV-2 replication

Yuzheng Zhou
Zongpeng Chen
Zanxian Xia
ResearchOpen Access28 Jun 2024
Signal Transduction and Targeted Therapy

Volume: 9, P: 1-18
A Fully-Automatic Multiparametric Radiomics Model: Towards Reproducible and Prognostic Imaging Signature for Prediction of Overall Survival in Glioblastoma Multiforme

Qihua Li
Hongmin Bai
Zhi-Cheng Li
ResearchOpen Access30 Oct 2017
Scientific Reports

Volume: 7, P: 1-9
RIPK3 signaling and its role in regulated cell death and diseases

Yaqi Zhou
Yaxuan Xiang
Lei Zhang
ReviewsOpen Access29 Apr 2024
Cell Death Discovery

Volume: 10, P: 1-14

Search

Filter By:

Search

Quick links