Advanced search

Filter By:

Journal Check one or more journals to show results from those journals only.

Choose more journals

Article type Check one or more article types to show results from those article types only.
Subject Check one or more subjects to show results from those subjects only.
Date Choose a date option to show results from those dates only.

Custom date range

Clear all filters
Sort by:
Showing 1–9 of 9 results
Advanced filters: Author: Silvi Rouskin Clear advanced filters

  • Telomerase assembles on a multi-___domain RNA scaffold that must adopt a specific structure to function. Here, the authors reveal an alternative RNA conformation in living cells that disrupts telomerase activity, suggesting RNA misfolding may challenge proper telomerase assembly.

    • Nicholas M. Forino
    • Jia Zheng Woo
    • Michael D. Stone
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-15

  • Lan et al. report RNA structure ensembles across the entire SARSCoV-2 genome in infected human cells at single nucleotide resolution. They find alternative RNA conformations critical for promoting near-native frameshifting rates in ORF1ab.

    • Tammy C. T. Lan
    • Matty F. Allan
    • Silvi Rouskin
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-14

  • Hybrid nucleic acid origami has potential for biomedical delivery of mRNA and fabrication of artificial ribozymes. Here, the authors use chemical footprinting and cryo-electron microscopy to reveal insights into nucleic acid origami used to fold messenger and ribosomal RNA into 3D polyhedral structures.

    • Molly F. Parsons
    • Matthew F. Allan
    • Mark Bathe
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-14

  • DMS-MaPseq enables genome-wide and target-specific RNA secondary structure probing of even rare or heterogeneously structured RNAs in vivo and was used to study structure involved in translation regulation as well as nascent transcripts.

    • Meghan Zubradt
    • Paromita Gupta
    • Silvi Rouskin
    Research
    Nature Methods
    Volume: 14, P: 75-82

  • Despite approved vaccines and anti-virals to prevent and treat SARS-CoV-2 infection, there is a need for further development of efficient antiviral therapeutic strategy. Here, Zhu et al. develop locked nucleic acid antisense oligonucleotides (LNA ASOs) targeting the 5’ leader sequence of SARS-CoV-2 RNA to interfere with replication of wildtype virus and variants of concern. Daily intranasal administration in K18-hACE2 humanized mice suppresses viral infection in lung.

    • Chi Zhu
    • Justin Y. Lee
    • Anders M. Näär
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-13

  • Dimethyl sulfate mutational profiling with sequencing, combined with the newly developed DREEM algorithm, reveals that heterogeneity of RNA structure in HIV-1 regulates the use of splice sites and expression of viral genes.

    • Phillip J. Tomezsko
    • Vincent D. A. Corbin
    • Silvi Rouskin
    Research
    Nature
    Volume: 582, P: 438-442

  • Understanding how RNA structure influences its function has been hampered by a lack of approaches that can accurately quantify RNA structure in vivo; here, RNA structure is revealed on a global scale and with nucleotide-level resolution, showing that there is less structure within cells than expected from in vitro and in silico analyses.

    • Silvi Rouskin
    • Meghan Zubradt
    • Jonathan S. Weissman
    Research
    Nature
    Volume: 505, P: 701-705