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Showing 1–5 of 5 results
Advanced filters: Author: Simone Tangermann Clear advanced filters

  • Candida albicans, the most common human fungal pathogen, causes local and life-threatening systemic infection. Here, the authors show that absence of tyrosine kinase 2 protects from invasive cutaneous candidiasis.

    • Sara Miranda
    • Caroline Lassnig
    • Birgit Strobl
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-16

  • Anaplastic large cell lymphoma (ALCL) is an aggressive T-cell lymphoma often with poor prognosis. To identify genes defining ALCL cell state and dependencies, the authors here characterize ALCL-specific super-enhancers and describe the BATF3/IL-2R−module as a therapeutic opportunity for ALCL.

    • Huan-Chang Liang
    • Mariantonia Costanza
    • Olaf Merkel
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-12

  • Anaplastic lymphoma kinase (ALK) inhibitors are currently being considered in neuroblastoma (NB), but its acquired resistance is reported in non-small cell lung cancers. Here, the authors have found PIM1 overexpression decreases sensitivity to ALK inhibitors in NB and combined ALK and PIM1 inhibition enhances anti-tumour efficacy in vitro and in PDX models.

    • Ricky M. Trigg
    • Liam C. Lee
    • Suzanne D. Turner
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-13

  • Hyper-activated STAT5B and its disease-causing variants are of interest as cancer drug targets. Here the authors combine cell based studies, X-ray crystallography, biophysical experiments and MD simulations to structurally and functionally characterize the STAT5BN642H mutant found in aggressive T-cell leukemia and lymphomas and find that it has an increased affinity for self-dimerization.

    • Elvin D. de Araujo
    • Fettah Erdogan
    • Patrick T. Gunning
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-15