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A method for acetylome profiling requiring a low quantity of hematopoietic stem cells (HSCs) was developed, revealing a significant reduction in H4K77ac in aged HSCs, associated with decreased lymphocyte differentiation potential.

Missing modality challenges longitudinal omics studies. Here, the authors introduce LEOPARD, a pioneering neural network that uses style transfer to re-entangle omics data, enabling robust imputation and unlocking fresh insights into predictive healthcare and biological temporal dynamics.

Extracellular matrices are viscoelastic, yet how matrix viscoelasticity regulates the epigenome remains unclear. Here, the authors show that cells cultured on viscoelastic matrices exhibit changes in the nucleoskeleton and in chromatin that enhance cell reprogramming.

This study develops a method for spatially resolving multipotent haematopoiesis, erythropoiesis and lymphopoiesis in mice and uncovers heterogeneous haematopoietic stress responses in different bones.

The coupling of acetonitrile into succinonitrile via a dehydrogenative route is highly attractive in terms of valuable chemical synthesis and green hydrogen energy production. Here, the authors report succinonitrile synthesis with high selectivity and rate via a light driven dehydrogenative coupling reaction of CH₃CN over the anatase TiO₂ supported Pt catalyst.

Molybdenum disulfide vertical transistors with channel lengths down to one atomic layer can be made with metal electrodes using a mechanical van der Waals transfer process that leads to a high-quality metal–semiconductor interface.

Liver-resident natural killer cells develop locally and have multiple immunological roles in situ. Here the authors investigate the gut-liver axis and show the impact of the intestinal microbiota on the development of liver-resident natural killer cells.

The storage of holes in quantum-dot light-emitting diodes between high-frequency pulsed electrical excitations can create an excitation-history-dependent transient response, allowing the response speed of the devices to be increased.

Xu, Zhang, Xuan et al. show that PD-1 signalling defines a population of leukaemia stem cells with features of quiescence, drug resistance and protection against cell death, ablation of which suppresses disease progression of mouse and human T-ALL.

Validation of the safety and performance of a wearable ultrasound sensor for the monitoring of blood pressure in clinical settings showed that the sensor met established safety and accuracy requirements.

Jie Qiaoa, Wenqiang Lia, Siyu Lina et al. develop a cost-efficient method to prepare stable and efficient CRISPR/Cas ribonucleoprotein complexes. Using a one-step purification system with an ultra-high-affinity CL7/Im7 column they successfully harvested high yields of functional Cas9 and target-specific single guided RNAs co-expressed in Escherichia coli.

An echomyography system based on a single transducer can be integrated into a wearable patch and used to monitor breathing patterns and hand gestures.

Ethylene glycol, widely utilized with over 40 million tons produced annually, is typically made with high CO₂ emissions. Here, the authors report an electrochemical method to produce ethylene glycol from biomass glycerol, offering a more sustainable, low-emission alternative.

Invariant cell lineage in C. elegans enables the analysis of transcriptional regulatory mechanisms controlling the fate of each cell at spatiotemporal resolution. Here, the authors develop a tool automating C. elegans cell identification and create an expression atlas of 620 transcription factors.

Ji et al. report that under basal conditions the SEL1L–HRD1 complex for endoplasmic reticulum-associated degradation ubiquitinates and negatively regulates STING protein levels in the endoplasmic reticulum, hence its activation.

The authors show that abnormal elevation of osteocyte-derived sclerostin deregulates Wnt–β-catenin signalling in the brain and aggravates cognitive impairment under pathological conditions.

Adipose stem cells are promising therapeutic agents in tissue regeneration. Here the authors develop a lipid nanoparticle/RNA engineering platform to enhance the protein production of these cells, which demonstrate superior healing efficacy in a mouse model of diabetic cutaneous wounds.

In this study, the authors report a potent neutralizing antibody targeting a conserved epitope within RSV pre-F that shows higher antiviral activity against both RSV-A and -B subgroups in vitro and in small animal models than FDA-approved prophylactic agents.

Multi-region sequencing of small cell lung cancers (SCLC) can improve our understanding of the disease. Here the authors analyse 120 multi-region samples from 40 SCLC patients with whole exome sequencing and characterise their mutational burden, evolution, heterogeneity, and potential prognostic biomarkers.

Atomically dispersed Pt on an α-MoC support exhibits high CO tolerance during selective hydrogenation of nitrobenzene and its derivatives.

Base editors can make targeted changes without inducing a double-stranded break. Here, the authors apply the BE3 and ABE7.10 systems to rabbit to create highly efficient targeted base substitutions and various mutation types, and show reduced frequency of undesired by-products with the updated BE4-Gam system.

Low-temperature CO₂ methanation processes have potential for improved energy efficiency due to high equilibrium conversion but are generally limited by poor catalyst activity. Here the authors report an inverse CeZrO_x/Ni catalyst that realizes high low-temperature (200 °C) methanation activity at ambient pressure.

Ensembles of fear and extinction memories compete and interact to drive opposing behaviors. Here the authors identified insular cortical circuits as an executive gateway that decipher between fear and extinction memories via distinct subcortical pathways.

Induced pluripotent stem cell (iPSC)-derived macrophages (iMACs) are being used to make chimeric antigen receptor (CAR) macrophages for immunotherapy. Here the authors design a second-generation macrophage-specific CAR by integrating CD3ζ and toll/IL-1R (TIR) domains resulting in an M1-polarized CAR-iMAC with increased antitumor functions.

RNA nanostructures have been demonstrated in a range of biological applications, but their assembly and delivery to cells is difficult. Here the authors demonstrate the in vivo assembly of a RNA nanostructure from a single transcript inside the cellular environment.

An inverse CeAlO_x/Ni/Ni-foam structured catalyst with high thermal stability and water resistance is shown to be effective at CO₂ methanation across a wide temperature range because of efficient heat/mass transport.

Here, the authors identify neuron-specific miR-9 that potentially blocks HSV-1 neuronal replication by targeting host OCT-1 and ONECUT transcription factors involved in epigenetic activation of HSV-1 productive-cycle genes. Thus miR-9 promotes viral epigenetic silencing and latent infection in neurons.

Ran et al. report that excess cardiovascular mortality in the United States during the first two years of the COVID-19 pandemic coincided with the waves of COVID-19 deaths and was demographically diverse.

Hepatic insulin resistance plays a central role in metabolic syndrome. Here, the authors show that transcription factor BACH1 acts as a negative regulator of insulin signaling and that hepatic BACH1 deficiency ameliorates hyperglycemia and insulin resistance in high-fat diet-fed or diabetic mice

The time-varying metasurfaces show promise for exploring exotic physics and photonic applications. The authors introduce a time-varying metasurface with superconductor-metal hybrid meta-molecules, demonstrating phase-controllable frequency conversion with high efficiency.

A conformal ultrasound patch can be used for hands-free volumetric imaging and continuous monitoring of cerebral blood flow

Reversing the thermal induced sintering phenomenon and forming high temperature stable fine dispersed metallic centers is one of the ever-lasting targets in heterogeneous catalysis. Here the authors report the dispersion of metallic Ni particles into under-coordinated two-dimensional Ni clusters over γ-Mo₂N.

The working temperature of boron-based catalysts reduces their thermodynamic advantages in the oxidative dehydrogenation of propane (ODHP). Here the authors demonstrate encapsulated Ni nanoparticles as effective subsurface promoters to enhance the low temperature activity and selectivity of the boron oxide overlayer in ODHP.

Enhancing the intrinsic activity and space time yield of Cu based heterogeneous methanol synthesis catalysts is one of the major topics in CO₂ hydrogenation. Here the authors develop a highly active inverse catalyst composed of fine ZrO₂ islands dispersed on metallic Cu nanoparticles.

As an alternative vehicle fuel, hydrogen can be generated in situ from methanol and water—a process that is shown here to occur under mild conditions using a catalyst that comprises platinum atomically dispersed on an α-molybdenum carbide substrate.