Nature Search

MLL oncoprotein levels influence leukemia lineage identities

The effects of chromosomal translocations involving the mixed-lineage leukemia (MLL) locus on gene expression regulation remain to be explored. Here, the authors find that MLL oncoproteins support lineage-switching events through dynamic chromatin binding.

Derek H. Janssens
Melodie Duran
Steven Henikoff
ResearchOpen Access29 Oct 2024
Nature Communications

Volume: 15, P: 1-13
Cellular immunotherapy targeting CLL-1 for juvenile myelomonocytic leukemia

JMML is an aggressive hematologic malignancy with myeloproliferative characteristics affecting young children. Here the authors report that C-type lectin-like molecule-1 (CLL-1) is upregulated in JMML and they develop CLL-1 CAR T cells showing in vitro and in vivo anti-JMML activity.

Juwita Werner
Alex G. Lee
Elliot Stieglitz
ResearchOpen Access23 Apr 2025
Nature Communications

Volume: 16, P: 1-20
Automated CUT&Tag profiling of chromatin heterogeneity in mixed-lineage leukemia

Automated and single-cell CUT&Tag is used to characterize the effects of KMT2A fusion proteins on chromatin in human primary leukemia samples, identifying oncogenic networks and fusion-specific therapeutic vulnerabilities.

Derek H. Janssens
Michael P. Meers
Steven Henikoff
ResearchOpen Access18 Oct 2021
Nature Genetics

Volume: 53, P: 1586-1596
Erratum: The molecular landscape of pediatric acute myeloid leukemia reveals recurrent structural alterations and age-specific mutational interactions

Hamid Bolouri
Jason E Farrar
Soheil Meshinchi
Amendments and Corrections01 Apr 2018
Nature Medicine

Volume: 24, P: 526
Author Correction: Myeloid lineage enhancers drive oncogene synergy in CEBPA/CSF3R mutant acute myeloid leukemia

Theodore P. Braun
Mariam Okhovat
Julia E. Maxson
Amendments and CorrectionsOpen Access16 Jun 2022
Nature Communications

Volume: 13, P: 1
Inflammatory bone marrow signaling in pediatric acute myeloid leukemia distinguishes patients with poor outcomes

IL6 expression in the bone marrow is associated with reduced survival in paediatric AML. Here, the authors used RNA-seq to identify treatment resistance-associated co-occurring inflammatory signalling in leukemic cells.

Hamid Bolouri
Rhonda E. Ries
Soheil Meshinchi
ResearchOpen Access23 Nov 2022
Nature Communications

Volume: 13, P: 1-12
The genomic basis of childhood T-lineage acute lymphoblastic leukaemia

Comprehensive genomic and transcriptomics analyses of more than 1,300 cases of childhood T-lineage acute lymphoblastic leukaemia identify 15 distinct subtypes that are associated with specific outcomes.

Petri Pölönen
Danika Di Giacomo
David T. Teachey
Research14 Aug 2024
Nature

Volume: 632, P: 1082-1091
Integrated stem cell signature and cytomolecular risk determination in pediatric acute myeloid leukemia

Relapsed pediatric acute myeloid leukemia is associated with poor prognosis. Here, the authors use RNA-seq data from 1503 primary samples to create a combined transcriptional and cytomolecular signature to improve relapse risk prediction.

Benjamin J. Huang
Jenny L. Smith
Soheil Meshinchi
ResearchOpen Access19 Sept 2022
Nature Communications

Volume: 13, P: 1-11
ABCB1 SNP predicts outcome in patients with acute myeloid leukemia treated with Gemtuzumab ozogamicin: a report from Children’s Oncology Group AAML0531 Trial

Roya Rafiee
Lata Chauhan
Jatinder K. Lamba
ResearchOpen Access21 May 2019
Blood Cancer Journal

Volume: 9, P: 1-8
Publisher Correction: The molecular landscape of pediatric acute myeloid leukemia reveals recurrent structural alterations and age-specific mutational interactions

Hamid Bolouri
Jason E Farrar
Soheil Meshinchi
Amendments and Corrections31 Jan 2019
Nature Medicine

Volume: 25, P: 530
Etiology of oncogenic fusions in 5,190 childhood cancers and its clinical and therapeutic implication

Oncogenic gene fusions are frequent in childhood cancers but remain poorly understood and untargeted. Here, the authors identify 272 oncogenic fusions in transcriptomics data from 5190 childhood cancer patients, revealing their possible etiologies, their links with tumor progression and evolution, and their potential as therapeutic targets.

Yanling Liu
Jonathon Klein
Xiaotu Ma
ResearchOpen Access05 Apr 2023
Nature Communications

Volume: 14, P: 1-18
Genomic subtyping and therapeutic targeting of acute erythroleukemia

Analysis of genomic and clinical features of acute erythroid leukemia in comparison to other myeloid disorders supports its distinct classification, defines subgroups and suggests therapeutic vulnerabilities.

Ilaria Iacobucci
Ji Wen
Charles G. Mullighan
Research29 Mar 2019
Nature Genetics

Volume: 51, P: 694-704
The genetic basis and cell of origin of mixed phenotype acute leukaemia

A large-scale genomics study shows that the cell of origin and founding mutations determine disease subtype and lead to the expression of multiple haematopoietic lineage-defining antigens in mixed phenotype acute leukaemia.

Thomas B. Alexander
Zhaohui Gu
Charles G. Mullighan
Research12 Sept 2018
Nature

Volume: 562, P: 373-379
Myeloid lineage enhancers drive oncogene synergy in CEBPA/CSF3R mutant acute myeloid leukemia

Acute Myeloid Leukemia (AML) develops following multiple mutations of differing impact. Here, the authors show that activating mutations of CSF3R co-operate with loss-of-function mutations of CEBPA to promote AML development through an enhancer-dependent mechanism.

Theodore P. Braun
Mariam Okhovat
Julia E. Maxson
ResearchOpen Access29 Nov 2019
Nature Communications

Volume: 10, P: 1-15
Notch blockade overcomes endothelial cell-mediated resistance of FLT3/ITD-positive AML progenitors to AC220 treatment

Quy Le
Brandon Hadland
Irwin Bernstein
Research08 Jun 2020
Leukemia

Volume: 35, P: 601-605
Pan-cancer genome and transcriptome analyses of 1,699 paediatric leukaemias and solid tumours

Analysis of the genomes, exomes and transcriptomes of 1,699 childhood cancers identifies 142 driver genes.

Xiaotu Ma
Yu Liu
Jinghui Zhang
ResearchOpen Access28 Feb 2018
Nature

Volume: 555, P: 371-376
The molecular landscape of pediatric acute myeloid leukemia reveals recurrent structural alterations and age-specific mutational interactions

A comprehensive molecular analysis of almost 1,000 pediatric subjects with acute myeloid leukemia (AML) uncovers widespread differences in pediatric AML as compared to adult AML, including a higher frequency of structural variants and different mutational patterns and epigenetic signatures. Future studies are needed to characterize the functional relevance of these alterations and to explore age-tailored therapies to improve disease control in younger patients.

Hamid Bolouri
Jason E Farrar
Soheil Meshinchi
Research11 Dec 2017
Nature Medicine

Volume: 24, P: 103-112
Integrated drug resistance and leukemic stemness gene-expression scores predict outcomes in large cohort of over 3500 AML patients from 10 trials

Abdelrahman H. Elsayed
Xueyuan Cao
Jatinder K. Lamba
ResearchOpen Access01 Aug 2024
npj Precision Oncology

Volume: 8, P: 1-12
Transcriptome free energy can serve as a dynamic patient-specific biomarker in acute myeloid leukemia

Lisa Uechi
Swetha Vasudevan
Nataly Kravchenko-Balasha
ResearchOpen Access25 Mar 2024
npj Systems Biology and Applications

Volume: 10, P: 1-10
High caspase 3 and vulnerability to dual BCL2 family inhibition define ETO2::GLIS2 pediatric leukemia

Zakia Aid
Elie Robert
Thomas Mercher
Research30 Dec 2022
Leukemia

Volume: 37, P: 571-579
A ten-gene DNA-damage response pathway gene expression signature predicts gemtuzumab ozogamicin response in pediatric AML patients treated on COGAAML0531 and AAML03P1 trials

Mohammed O. Gbadamosi
Vivek M. Shastri
Jatinder K. Lamba
Research10 Jun 2022
Leukemia

Volume: 36, P: 2022-2031
Prognosis of relapse after hematopoietic cell transplant (HCT) for treatment of leukemia or myelodysplastic syndrome (MDS) in children

Ann Dahlberg
Wendy Leisenring
Ann Woolfrey
Research22 Jan 2019
Bone Marrow Transplantation

Volume: 54, P: 1337-1345
Genetic mechanisms of primary chemotherapy resistance in pediatric acute myeloid leukemia

Nicole A. McNeer
John Philip
Alex Kentsis
Research13 Feb 2019
Leukemia

Volume: 33, P: 1934-1943
Distinct Metabolic features differentiating FLT3-ITD AML from FLT3-WT childhood Acute Myeloid Leukemia

Bradley Stockard
Timothy Garrett
Jatinder Lamba
ResearchOpen Access03 Apr 2018
Scientific Reports

Volume: 8, P: 1-9
Menin inhibitors in pediatric acute leukemia: a comprehensive review and recommendations to accelerate progress in collaboration with adult leukemia and the international community

Branko Cuglievan
Hagop Kantarjian
Ghayas C. Issa
ReviewsOpen Access23 Aug 2024
Leukemia

Volume: 38, P: 2073-2084
Blastic plasmacytoid dendritic cell neoplasm: a comprehensive review in pediatrics, adolescents, and young adults (AYA) and an update of novel therapies

Branko Cuglievan
Jeremy Connors
Naveen Pemmaraju
ReviewsOpen Access14 Jul 2023
Leukemia

Volume: 37, P: 1767-1778
The 5th edition of the World Health Organization Classification of Haematolymphoid Tumours: Myeloid and Histiocytic/Dendritic Neoplasms

Joseph D. Khoury
Eric Solary
Andreas Hochhaus
ReviewsOpen Access22 Jun 2022
Leukemia

Volume: 36, P: 1703-1719

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