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TNF inhibitor (TNFi) has been used to manage active inflammation in ankylosing spondylitis (AS), but not all patients respond. Here, through longitudinal and multi-omics profiling, the authors show that elevated type-I IFN signature and allograft inflammatory factor-1 expression at baseline inversely correlate with TNFi responsiveness in AS patients.

Chronic care manages long-term, progressive conditions, while acute care handles short-term ones. Here, authors show chronic conditions account for most of the global health burden, with 68% of DALYs and 93% of YLDs attributed to chronic care needs.

Edge computing devices must be compact and energy efficient for use in low-power environments. Here, the authors propose a flexible memristive dot product engine designed for edge use with 0.3% energy consumption compared to digital approaches.

Determining graphene ___domain size and distribution is important for realizing functional electronic devices. Here, the authors use liquid crystals to study graphene surfaces, via the liquid crystal molecules aligning with the domains, and use nematic to smectic transitions to study defects.

The glucoregulatory functions of pancreatic islets are affected by their surrounding niche and spatial organization. Here, bioengineered stem-cell derived islet niches use bioprinting-based geometrical guidance to promote islet maturation for improved functionality and diabetes research.

A photoreactive crosslinker can be used to directly pattern thin films of exfoliated two-dimensional flakes, and the technique can be performed sequentially to create patterned van der Waals heterostructures at wafer scales.

Subtyping of non-small cell lung cancer can be challenging based on pathology. Here, the authors utilise multi-omics analysis of 229 patients to identify further subtypes, and altered immune composition between subtypes.

The extracellular matrix is remodeled to form complex interconnected network structures that regulate stem cell behaviors. Here, the authors modulate extracellular matrix-like networks using magnetic nano-blockers, adjusting stem cell behavior by changing ligand inter-cluster connectivity. This dynamic system provides new insights into cell-material interactions for tissue regeneration.

Kim and colleagues perform a phase 2 clinical trial (ELM-2) of odronextamab monotherapy in patients with relapsed/refractory diffuse large B cell lymphoma and report on the primary analyses of the efficacy and safety profile.

By engineering the upper and lower surfaces of micro-light-emitting-diode chips to have different van der Waals forces, hundreds and thousands of chips can be accurately aligned on substrates and used to create active-matrix displays.

Electrides are an emerging family of materials with potential for hosting topological states. Here, the authors demonstrate the presence of Fermi-arc surface states in close proximity to the floating electron layer on the surface of an electride.

A stealthy neural recorder allows for the study of the behaviour of non-human primates in naturalistic settings.

An analysis of memory T cells induced by messenger RNA vaccination reveals that they maintain polyfunctionality in response to the Omicron spike protein.

The protein MG53 is known to inhibit myogenesis. Here, Ko et al. show that MG53 is an E3 ubiquitin ligase that mediates degradation of insulin receptor substrate 1 in skeletal muscle, thereby regulating myogenesis and insulin sensitivity in vitro and in vivo.

Despite advances in ctDNA cancer detection, early detection remains difficult. Here, the authors utilise whole genome sequencing of 2,125 patient samples to create a model for early cancer and tissue of origin detection.

A transparent twistable and stretchable MoO₃/Au/MoO₃ electrode is demonstrated by Choi et al. for organic light-emitting diodes. The device fabricated on thin elastomer shows enhanced EQE with minimum efficiency roll-off owing to the improved charge injection and heat dissipation from the substrate.

Analysis of genomic and transcriptomic data from 462 patient-derived tumor cell (PDC) samples across 14 cancer types, along with pharmacological responses to 60 agents, indicates that PDC-derived drug sensitivities might be predictive of clinical response to targeted therapies.

tRNA synthetases are essential to protein synthesis. Kim and colleagues identify a non-translational function for glutamyl-prolyl-tRNA synthetase during viral infection that promotes the anti-viral activity of the antiviral signaling protein MAVS.

SCOPE detects low-abundance extracellular vesicle mRNA with high sensitivity for clinical applications.

The prognosis and treatment of gastric cancer is complicated by heterogeneity. Here, the authors reveal two molecular subtypes, the mesenchymal subtype associated with poor survival and chemoresistance, and the epithelial phenotype associated with better survival and sensitivity to chemotherapy.

In patients with advanced gastric cancer (AGC), resistance to treatment with trastuzumab and cytotoxic chemotherapy remains high. Here, the authors report the results of a phase Ib/II clinical trial assessing the safety and clinical response to a quadruplet regimen of pembrolizumab, trastuzumab, capecitabine, and cisplatin as a first-line therapy for HER2-positive AGC.

Polypeptide N-acetyl-galactosaminyltransferases (GALNTs) are associated with cancer, but their function in organ-specific metastasis is unclear. Here the authors show that GALNT14 promotes breast cancer metastasis to the lung by enhancing the initiation of metastatic colonies and subsequent growth.

Severe fever with thrombocytopenia syndrome virus (SFTSV) is an emerging tick-borne virus with no specific treatment or vaccine available. Here, the authors develop a DNA vaccine for SFTSV that is protective against lethal challenge in ferrets and show that anti-envelope antibodies are important for protection.

Yeom et al. demonstrate that tumour cell-secreted Dilp8/INSL3 activates Lgr3 signalling and modulates expression of distinct feeding hormones such as NUCB1 and sNPF, thereby inducing anorexia in cancer.

Non-zero topological charge prevents the straight motion of ferromagnetic skyrmions and hinders their applications. Here, the authors report the stabilization and current-driven dynamics of skyrmions in GdFeCo films in which the ferrimagnetic skyrmions can move with high velocity and reduced skyrmion Hall angle.

Transmission of alpha-synuclein aggregates between neurons has been observed in animal models of Parkinson’s disease, however, the mechanism of transmission remains unclear. Bae et al. report that a cycle of uptake, co-aggregation and exocytosis is enhanced by loss of glucocerebrosidase activity.

Wnts are important for synapse formation and maintenance. Here, the authors show that proline-rich 7 (PRR7) is a Wnt inhibitor that is secreted via exosomes to regulate excitatory synapse numbers.

Integration of diverse nanostructures allows the fabrication of a wearable system capable of storing data, performing diagnostics and delivering drugs.

Neuronal sphingosine kinase 1 (SphK1) acetylates COX2 which is needed for microglial phagocytosis activity, and release of pro-resolving mediators (SPMs) from neurons. Here the authors examine how SphK1-mediates COX2 acetylation, and how this leads to increased secretion of SPMs from neurons in the context of Alzheimer’s disease models.

The protein PHF20 is expressed in various cancers, but little is known about its cellular function. Here, Zhang and colleagues show that PHF20 regulates NF-κB signalling by inhibiting the interaction between its subunit p65 and the phosphatase PP2A, thereby maintaining NF-κB in an active state in the nucleus.

The penetration of tissues with syringe needles is a common clinical practice that inevitably results in blood loss at the puncture site. This blood loss can now be eliminated using self-sealing haemostatic needles.