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Traditional nanopore sensors use barrel-shaped protein channels. Here, the authors report on a study into the use of globular protein, ferritin, as a nanopore sensor, demonstrating membrane insertion and sensor application, showing the potential of non-barrel-shaped proteins for nanopore sensing.

Traditional theory favors positively charged membranes for Li+ /Mg2+ separation, but practical use prefers negatively charged ones. The authors uncover a counter-ion competition mechanism in negatively charged nanofiltration membranes, achieving high Mg2+ rejection and exceptional Li+ permeability.

Sodium-air batteries are appealing energy storage systems due to high theoretical energy density and high sodium abundance. But they are plagued with low efficiency and large overpotential. Here, authors report long-term reversibility over 1000 cycles with 99% efficiency using a cascade electrocatalysis strategy based on Na[Li_1/3Ru_2/3]O₂ electrodes.

Membranes which extract lithium are critical to developing sustainable technologies. Here, the authors report a covalent organic framework featuring randomly oriented channels, separating lithium from a mixture of cations.

Rice indica varieties have higher nitrogen use efficiency (NUE) than that of japonica varieties. Here, the authors show that natural variation of OsWRKY23 and its interaction with DULL NITROGEN RESPONSE1 (DNR1)-mediated auxin accumulation play a role in NUE divergence between the two rice subspecies.

High-energy aqueous metal batteries are promising candidates for the next-generation energy storage systems yet face detrimental parasitic reactions. Here, authors develop a durable cadmium-metal battery employing a fast-kinetics dual-structure-breaking electrolyte.

Across 21 societies, people alter their speech and song when interacting with infants. These infant-directed vocalizations are recognized by listeners. This suggests that forms of human vocalizations may be shaped by their functions.

A miniaturized and low-power-consumption system is designed to allow the accurate sensing and wireless transmission of internal temperature and strain signals inside lithium-ion batteries with negligible influence on their performance, improving their safety.

Zhang, Huang, Wang, Long et al. report that NAT10 enhances serine uptake and biosynthesis in an ac4C-dependent mechanism, thereby promoting stemness and progression in acute myeloid leukaemia.

Accessing strong correlation effects in Kagome materials remains challenging. Here, the authors realize a Kagome Kondo lattice in CsCr₆Sb₆ exhibiting flat, isolated Kagome bands at the Fermi level.

Proteome profiling of plasma samples in human pan-cancer cohorts reveals patterns of biomarkers for diagnosis.

The development of high-performance positive electrode materials for sodium-ion batteries is crucial for energy storage. Here, authors synthesize a layered-columnar framework material with achieving high ionic conductivity and improved stability.

The authors assess shell thickness and ornamentation in brachiopods during the Permian–Triassic mass extinction (PTME) and in foraminifera during both the PTME and early Toarcian oceanic anoxic event, finding that both groups reduced their morphological complexity and thus possibly saved on energetic costs during these stressful events.

Monomethylation of histone H4 lysine 20 (H4K20me1) contributes to DNA replication but the mechanism is not well understood. Here, the authors identify a conserved tandem Tudor ___domain of BAHCC1 as a H4K20me1-specific reader, which promotes the recruitment of MCM complex to chromatin for efficient DNA replication.

Extending the endurance of mushroom-type phase change memory remains challenging. Here, the authors design a nano-confined cell with an embedded heater, achieving a 1000 × improvement and attributing failure to carbon-induced collapse of the switching volume.

The Einstein Probe has discovered a fast X-ray transient, EP240414a, associated with a broad-lined type Ic supernova. Its unusually soft spectrum and weak jet add to the diversity of stellar deaths and suggest a previously unknown Wolf–Rayet star explosion mechanism.

Controlling droplet motion after impact on solid surfaces is crucial for applications like self-cleaning and microfluidics, yet the fundamental limit of the droplet rebound angle remains unknown. This study reveals a droplet behavior where it rapidly rolls with a rebound angle near zero, defining the lower limit, enabled by asymmetric adhesion on nanostructured surfaces, resulting in greatly enhanced cleaning efficiency and precise droplet transport.

Complex traits present challenges for gene mapping and molecular characterization. Here, the authors develop a 16-generation intercross line of chickens to explore the genetic architecture of complex traits in chicken.

Dopaminergic dysfunction is a key of Alzheimer’s disease pathogenesis. Here, the authors developed a multifunctional neural interface that simultaneously monitors dopamine dynamics and neural activity while delivering 40 Hz stimulation to rescue cognitive deficits in APP/PS1 mice.

2D Ta-based transition metal dichalcogenides have been predicted to host highly confined plasmons, but their observation has been lacking. Here, the authors report momentum-resolved electron energy loss spectroscopy measurements of 2H-TaS₂ monolayers and bilayers, showing plasmon resonances with lateral confinement up to 300 and group velocity down to ~10⁻⁴c at large wave vectors.

Xiang et al. use patient samples and mouse models of osteoarthritis to examine the link with muscle atrophy. They identify that, in osteoarthritis, senescent macrophages promote ferroptosis in skeletal muscle cells, and they show the therapeutic value of targeting this pathological mechanism.

Here the authors show that viral infections facilitate accumulation of cellular iron by degradation of iron exporter ferroportin (FPN1), and that high intracellular iron suppresses type I IFN responses and autophagy by promoting TBK1 hydroxylation and STING carbonylation.

This study establishes a dynamic regulatory network for barley grain development integrating genetic, metabolic, and gene expression information, revealing the regulatory role of key transcription factors in barley grain flavonoid metabolism and grain color formation.

The authors show that NAT10 is upregulated with T cell antigen receptor signaling and that T cell-specific NAT10 deficiency results in diminished numbers of naive T cells, translating to an inability to mount a significant antiviral T cell response.

Electrification is a promising way to decarbonize the chemical industry but could also have important effects on power systems. Here the authors assess the impact of electrifying the production of methanol and ammonia on the Chinese power system in terms of emissions and potential security risks.

Rehmannia chingii is a traditional Chinese medicinal plant that can produce iridoid glycoside. Here, the authors report its genome assembly and the elucidation of the iridoid biosynthetic pathway.

Nb-W-O materials enable rapid Li⁺ storage, yet sub-minute charging remains unlocked. Here, the authors investigate fast-charging of Nb₁₆W₅O₅₅ cathode, revealing rate-dependent lattice relaxation and [010]-preferred Li⁺ transport, proposing interface engineering to enhance intercalation and achieve ~116 mAh g⁻¹ at 80 C in 45 s.

Depletion of circulatory asparagine (Asn) by L-asparaginase (ASNase) has been used for clinical treatment of leukemia. Here this group develops core-shell structured cascade-responsive nanoparticles for sequential modulation of exogenous Asn supply and endogenous Asn production, thereby achieving the amino acid depletion therapy against solid tumors.

Su et al. report that the super-enhancer K5aSE orchestrates Klf5andadditional targets via 3D chromatin interactions in ES cells, with CTCF-mediated chromatin domains maintaining this regulatory network essential for ES cell identity.

Accurate tree cover mapping is vital for fighting climate change and land degradation. This high-resolution study reveals that 17% of pan-tropical tree cover was previously undetected, with over half of recent losses linked to human activities.

Certain antimetabolites used to treat cancer are more neurotoxic than others, and it is now shown that this is due to their greater tendency to generate DNA double-stranded breaks, whereas less neurotoxic agents induce single-stranded breaks.

Ma et al. report a regulatory mechanism by which lysine acetylation of the m⁶A reader protein OsECT3 modulates its m⁶A-binding activity under cold stress. The reduced acetylation level stabilizes cold-responsive mRNAs to enhance cold tolerance in rice.

Parasitoid wasps are reared and released as biocontrol agents to manage aphids and protect crops. Here, the authors use genomes from 542 wasps to show that, in spite of wide scale release of low-diversity captive individuals, diversity in wild populations is maintained.

To push the boundary of sol-gel chemistry towards high quality organic membrane construction is challenging. Here, the authors show a controlled nanocrystal suturing strategy in sol-gel solutions to afford highly crystalline and free-standing covalent organic framework membranes.

Optically active defects in wide band gap materials are promising building block for room temperature quantum information processing. Here, the authors connect the experimental variance in the optical spectra, optical lifetimes and spectral stability of quantum emitters to the distance-dependent donor-acceptor pairs in the two-dimensional hexagonal boron nitride.

While Bell inequalities have been violated several times—mostly in photonic systems—their violations within particle physics experiments are less explored. Here, the BESIII Collaboration showcases Bell-violating nonlocal correlations between entangled hyperon pairs.

Understanding the charge storage mechanism of electrode materials is critical for designing electrochemical energy storage devices. Here, authors study Li⁺ intercalation into two-dimensional metal carbides in nonaqueous electrolytes, revealing distinct behavior for different surface terminations.

Chronic care manages long-term, progressive conditions, while acute care handles short-term ones. Here, authors show chronic conditions account for most of the global health burden, with 68% of DALYs and 93% of YLDs attributed to chronic care needs.

Analysis of whole-genome sequencing data from hematopoietic stem and progenitor cells taken from patients with myeloma shows how treatment shapes clonal architecture and sheds light on the evolution of treatment-related myeloid neoplasms.

This study reports the synthesis of Ru₁Co single atom alloys with tunable crystal phases, revealing that the hexagonal-close-packed phase outperforms others in the nitrate reduction to ammonia due to shorter Ru-Co distances and stronger interatomic interactions, which improve NO₃⁻ adsorption.

DNA Damage Regulated Autophagy Modulator 1 (DRAM1) plays pivotal roles in autophagy regulation. Here, the authors show that DRAM1 stabilizes lysosomal VAMP8, thereby promoting autolysosome maturation. Furthermore, they establish that DRAM1–VAMP8 axis enhances autophagic flux and facilitates hepatocellular carcinoma extravasation, as validated in both zebrafish xenograft and mouse metastatic models.

This study uses deep learning and gaze-tracking to track pathologists' work and learn how they review tissue images. This “learned expertise” was applied to guide artificial intelligence models, such as weakly supervised learning and reinforcement learning, to achieve accurate diagnosis of Whole Slide Images.

Exosomes have huge potential for drug delivery, but drug loading can be difficult. Here, the authors report on fusogenic lipid nanoparticles which, when mixed with exosomes rapidly fuse, non-destructively loading large drugs without compromising exosome biological functions, and demonstrate neurological application.

When used in Chinese (versus English), generative artificial intelligence exhibits a more interdependent (versus independent) social orientation and a more holistic (versus analytic) cognitive style embedded in large-scale textual training.

Concise and enantioenriched synthesis of chiral carbocyclic and heterocyclic spirane scaffolds is a significant objective in both academic and industrial fields. Here, the authors report the kinetic resolution of racemic spirocyclic 1,3-diketones and their analogues via catalytic asymmetric hydrogenation with the SPA-PNN ligands.

Here the authors use genetic mutations to alter TCR signal strength and clonal selection of exhausted CD8⁺ T cells. They implicate CARD11 signaling as a sensor of this TCR signal strength and as a regulator of antitumor function in exhausted T cells that might be targeted to enhance cancer immunotherapies.

Breeding crops with delayed senescence could plausibly increase grain yield. Here the authors show that variation at the rice SGR locus contributes to differences in senescence between indica and japonica subspecies and show that introgression can increase yield in an elite indica rice variety.