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Rice indica varieties have higher nitrogen use efficiency (NUE) than that of japonica varieties. Here, the authors show that natural variation of OsWRKY23 and its interaction with DULL NITROGEN RESPONSE1 (DNR1)-mediated auxin accumulation play a role in NUE divergence between the two rice subspecies.

This study establishes a dynamic regulatory network for barley grain development integrating genetic, metabolic, and gene expression information, revealing the regulatory role of key transcription factors in barley grain flavonoid metabolism and grain color formation.

Optically active defects in wide band gap materials are promising building block for room temperature quantum information processing. Here, the authors connect the experimental variance in the optical spectra, optical lifetimes and spectral stability of quantum emitters to the distance-dependent donor-acceptor pairs in the two-dimensional hexagonal boron nitride.

Complex traits present challenges for gene mapping and molecular characterization. Here, the authors develop a 16-generation intercross line of chickens to explore the genetic architecture of complex traits in chicken.

The authors show that NAT10 is upregulated with T cell antigen receptor signaling and that T cell-specific NAT10 deficiency results in diminished numbers of naive T cells, translating to an inability to mount a significant antiviral T cell response.

Asymmetric migratory cross-coupling reactions, which proceed with heteroatom-based group migration, are challenging. Now a nickel-catalysed coupling reaction of amino alcohol-derived sulfonates with a variety of carbon-based electrophiles is reported, enabled by a radical 1,2-amino migration process. Modified chiral Bilm ligands are the key factor in achieving high stereoselectivity and reactivity.

Alpine plants exhibit phenological adaptations to germinate and complete their reproductive cycles during the most favorable growing seasons. Here, the authors show that allelic variation in the GA20ox3 gene is crucial for the adaptability of fruit length and seed germination timing in high-altitude ecotypes of A. thaliana.

The synthesis of atom-thin amorphous films remains challenging as their thermodynamically favourable grains are neither two dimensional nor layered. Here a droplet-driven nanoribbon-to-film growth strategy is reported to achieve amorphous metal chalcogenides at the single-layer limit.

This study reports the horizontal gene transfer of CSP genes from bacteria to Triticeae, promoting the adaptation and spread of wheat through enhanced drought tolerance and photosynthetic efficiency.

Here the authors identify genetic loci for asthma in East Asians using multi-trait GWAS. A CD36 missense variant shows protective effects and is validated through multi-omics, offering insights into asthma mechanisms and precision therapy.

While Bell inequalities have been violated several times—mostly in photonic systems—their violations within particle physics experiments are less explored. Here, the BESIII Collaboration showcases Bell-violating nonlocal correlations between entangled hyperon pairs.

A nanopore-based enzyme-linked immunosorbent assay is developed for the single-molecule sensing of distinct current signatures from peptide probes generated on translocation through α-hemolysin after enzymatic cleavage, enabling the multiplexed detection of biomarkers in blood samples.

The efficacy of anticancer gene therapy varies by the delivery efficiency of the mRNA cargo as well as their injection method. Here this group reports using LNP-delivered mRNA encoding 3 C protease treated on three different types of solid tumor models showing effective tumor growth inhibition, with three different injection methods, respectively.

Endothelial injury drives vascular diseases like atherosclerosis, but key regulators are unclear. Here, the authors show that endothelial major vault protein (MVP) acts as an intracellular regulator promoting Parkin-mediated mitophagy, thereby antagonizing vascular remodeling and suggesting its role as a potential therapeutic target.

Retarder arrays enable advanced photonic applications but are limited by controllable flexibility. Here, authors demonstrate a compound modulator that creates synthetic tuneable retarder arrays, offering unprecedented dynamic control of light, enabling new beam generation, analysis, and correction.

A nitrate-induced transcription factor TaTCP6 is identified as a central regulator for the efficient and balanced utilization of nitrate and phosphorus, and a moderate increase in its expression promotes wheat yield.

This study describes sets of plasma proteins linked to AIDS- and noncommunicable disease-related deaths in people with HIV, revealing unique proteomic patterns that could improve the prediction of mortality and inform more targeted prevention and treatment.

The prevalence of mutations that can predispose to pancreatic adenocarcinoma (PDAC) remains unclear, especially in underrepresented populations. Here, the authors create a germline mutation map of 1,123 Chinese PDAC patients and compare them to cohorts from other populations, finding CFTR as a potential driver.

An annually resolved 3476-year tree-ring record from the Tibetan Plateau reveals severe 20^th century droughts and highlights the interplay between the Asian Monsoon and Westerlies. Droughts are often linked to the collapse of dynasties.

Monolithic SiC metasurface is demonstrated to engineer arbitrary 3D perfect vector vortex beam and implement an optical anticounterfeiting scheme by using such beams. This method paves the way for advanced optical trapping and information security.

A cereal-specific transcription factor, ZmICE1a, positively regulates storage in the central part of the endosperm while negatively regulating defence in its peripheral region, revealing the molecular mechanism underlying the antagonism between resistance and yield, which is crucial for cereal crop improvement.

In a multicenter randomized phase 3 trial, stapokibart, a humanized monoclonal antibody that targets IL-4R alpha, significantly improved daily nasal and ocular symptom scores during the pollen phase in patients with moderate-to-severe seasonal allergic rhinitis.

Understanding the heterogeneity of epigenetic modifications is pivotal for unraveling cellular functions. Here, the authors developed a strategy based on multichrome encoding and “AND” Boolean logic recognition, termed as PREEM, for multiplexed imaging of m6A modifications of single-cell RNA.

Mixed-matrix membranes inherit the merits of both polymer materials and filler materials that hold potential for molecular separations, but precisely engineering the filler phase structure remains challenging. Here, the authors describe a reverse-filling approach to fabricate mixed-matrix membranes with continuous and vertically penetrating covalent organic framework channels, which exhibit high CO₂ separation performances, long-term stability and scale-up capability.

A gene-edited pig liver transplanted into a human recipient remains functional after 10 days and indicates that porcine organs could help meet the growing demand for liver transplants.

Propane dehydrogenation is an important reaction for the production of propylene, although effective catalysts are generally constructed from precious metals. Here, the authors report a high-performing earth-abundant alternative system for this reaction based on a particular form of cobalt on siliceous zeolites.

Mechanisms underlying changes in inflorescence development in response to high ambient temperature remain unclear. Here, the authors report the cloning of the MIB2, encoding a homology of SPATULA, and its activation of CONSTANS-Like1 for determining tomato inflorescence branching at high ambient temperature.

Magnaporthe oryzae effector MoSPAB1 enters rice nuclei to bind to the promoter of the immunity-brake gene Bsr-d1 and activates its expression by competing with rice MYBS1, which constitute a conserved module that facilitates fungal pathogenesis.

Trained on a large corpus of medical text and patient records and tested across diseases, with specific focus on rare presentations, an open-source medical language model demonstrates higher accuracy than commercial counterparts across specialties and improves accuracy of clinicians in a reader study.

A telomere-to-telomere genome assembly of allohexaploid bread wheat cv. Chinese Spring (CS-IAAS), along with transcriptomic and proteomic data, highlights wheat genome complexity and its structural and functional features.

Single reference genomes and short-read sequencing data are not enough to harness the full genetic variation of a species. Here, the authors report pan-genome of Arabidopsis thaliana based on chromosomal-level genomes of 32 accessions and identify variations associated with local adaptation.

The knowledge in the large language model (LLM), generative pre-trained transformer (GPT) 3.5, is elicited to facilitate the discovery of MRE11 in regulating sleep in the presence of conspecifics by a multi-object video tracking system.

Rearrangement reactions serve as crucial steps in syntheses of biologically active products and also provide intellectual and conceptual curiosities within the broad field of organic chemistry. Here, the authors report an electrophilic selenylation/semipinacol rearrangement of allenols, catalysed by a chiral Lewis base.

High-entropy alloy nanoparticles (HEA-NPs) are emerging advanced oxidation processes catalysts. Here, authors successfully load HEA-NPs onto a carbon-based carrier and demonstrate enhanced PMS activation, low oxidant consumption, and a rapid and efficient pollutant removal process.

It is a challenge to control composition gradient of ferroelectric films. Here, the authors develop a solution epitaxy strategy to produce compositionally-graded ferroelectric films with excellent dielectric stability and high pyroelectric property.

Memory effect is seldom found in ferroic domains after reversible phase transformations. Here, the authors develop a pair of single-component organic enantiomorphic multiferroic crystals with erasable ferroelectric and ferroelastic domains.

Nb-W-O materials enable rapid Li⁺ storage, yet sub-minute charging remains unlocked. Here, the authors investigate fast-charging of Nb₁₆W₅O₅₅ cathode, revealing rate-dependent lattice relaxation and [010]-preferred Li⁺ transport, proposing interface engineering to enhance intercalation and achieve ~116 mAh g⁻¹ at 80 C in 45 s.