Nature Search

Context information supports serial dependence of multiple visual objects across memory episodes

Visual cognition compensates for small changes in an object’s appearance to ensure its perceived continuity. We show that in situations with multiple objects, context features like color, temporal or spatial position are used as anchors to selectively integrate corresponding objects over time.

Cora Fischer
Stefan Czoschke
Christoph Bledowski
ResearchOpen Access22 Apr 2020
Nature Communications

Volume: 11, P: 1-11
Distinct immunological and molecular signatures underpinning influenza vaccine responsiveness in the elderly

Seasonal influenza vaccination is an important strategy to prevent serious disease in the elderly, but individual responsiveness to vaccination widely vary. Here authors establish, with an array of state-of-the art methods, the major immunological parameters that distinguish vaccine recipients developing robust antibody response and non-responders

Peggy Riese
Stephanie Trittel
Carlos A. Guzmán
ResearchOpen Access12 Nov 2022
Nature Communications

Volume: 13, P: 1-21
Postnatal expansion of mesenteric lymph node stromal cells towards reticular and CD34⁺ stromal cell subsets

Lymph nodes in various locations of the body differ in their cell composition and gene expression signatures. Here authors show that the rapid postnatal expansion of lymph nodes is governed by CD34 ⁺ stromal cells and fibroblastic reticular stromal cell progenitors, distinguished by intrinsic, microbiome-independent core epigenetic blueprints.

Joern Pezoldt
Carolin Wiechers
Jochen Huehn
ResearchOpen Access24 Nov 2022
Nature Communications

Volume: 13, P: 1-19
Acetyl-CoA-Carboxylase 1-mediated de novo fatty acid synthesis sustains Lgr5⁺ intestinal stem cell function

Here the authors report that inhibition of de novo fatty acid synthesis by deleting the enzyme Acetyl-CoA-Carboxylase 1 in the intestinal epithelium results in the loss of crypt structures and a specific decline in Lgr5+ intestinal epithelial stem cells.

Shuting Li
Chia-Wen Lu
Matthias Lochner
ResearchOpen Access09 Jul 2022
Nature Communications

Volume: 13, P: 1-15
Neonatally imprinted stromal cell subsets induce tolerogenic dendritic cells in mesenteric lymph nodes

Induction of tolerance in the gut relies on immunomodulatory functions of mesenteric lymph nodes (mLN). Here the authors show that mLN stromal cells receive early microbiota imprinting in the neonatal phase to exhibit long-term, ___location-specific transcriptional programs for the induction of regulatory T cells and peripheral tolerance.

Joern Pezoldt
Maria Pasztoi
Jochen Huehn
ResearchOpen Access25 Sept 2018
Nature Communications

Volume: 9, P: 1-14
K_2P18.1 translates T cell receptor signals into thymic regulatory T cell development

Tobias Ruck
Stefanie Bock
Sven G. Meuth
ResearchOpen Access26 Oct 2021
Cell Research

Volume: 32, P: 72-88
Efficient IL-2R signaling differentially affects the stability, function, and composition of the regulatory T-cell pool

Marc Permanyer
Berislav Bošnjak
Reinhold Förster
ResearchOpen Access06 Jan 2021
Cellular & Molecular Immunology

Volume: 18, P: 398-414
Vitamin C supports conversion of human γδ T cells into FOXP3-expressing regulatory cells by epigenetic regulation

Léonce Kouakanou
Christian Peters
Dieter Kabelitz
ResearchOpen Access16 Apr 2020
Scientific Reports

Volume: 10, P: 1-13
Targeting cellular fatty acid synthesis limits T helper and innate lymphoid cell function during intestinal inflammation and infection

Panagiota Mamareli
Friederike Kruse
Matthias Lochner
Research30 Apr 2020
Mucosal Immunology

Volume: 14, P: 164-176
Intact interleukin-10 receptor signaling protects from hippocampal damage elicited by experimental neurotropic virus infection of SJL mice

Ann-Kathrin Uhde
Malgorzata Ciurkiewicz
Andreas Beineke
ResearchOpen Access17 Apr 2018
Scientific Reports

Volume: 8, P: 1-13

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