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Showing 1–7 of 7 results
Advanced filters: Author: Steffen Reedtz-Runge Clear advanced filters

  • Cagrilintide is a long-acting agonist of amylin and calcitonin receptors in late phase trials for obesity. Here, authors present structures of cagilintide with each target receptor, revealing the molecular basis for its non-selective action.

    • Jianjun Cao
    • Matthew J. Belousoff
    • Patrick M. Sexton
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-15

  • Structures of human cholecystokinin receptors in complex with various ligands or G-proteins reveal how different ligand types are recognized and the basis of peptide selectivity in this receptor family, and suggest a stepwise activation mechanism.

    • Xuefeng Zhang
    • Chenglin He
    • Qiang Zhao
    Research
    Nature Chemical Biology
    Volume: 17, P: 1230-1237

  • Glucagon-like peptide-1 receptor (GLP-1R) plays an important role in glucose homeostasis and treatment of type 2 diabetes. Here authors report the peptide-free crystal structure of human GLP-1R in an inactive state which reveals a unique closed conformation of the extracellular ___domain.

    • Fan Wu
    • Linlin Yang
    • Raymond C. Stevens
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-10

  • The crystal structure of the full-length human glucagon receptor reveals the essential role of the 12-residue ‘stalk’ segment and an extracellular loop in the regulation of ligand binding and receptor activation.

    • Haonan Zhang
    • Anna Qiao
    • Beili Wu
    Research
    Nature
    Volume: 546, P: 259-264

  • G protein-coupled receptors (GPCRs) are the largest family of transmembrane signaling proteins in humans and exhibit diverse activation mechanisms. Here, the authors combine electron microscopy, hydrogen deuterium exchange and Molecular dynamics simulations to gain insight into the activation mechanism of the glucagon receptor.

    • Linlin Yang
    • Dehua Yang
    • Hualiang Jiang
    ResearchOpen Access
    Nature Communications
    Volume: 6, P: 1-13

  • The crystal structure of the full-length glucagon receptor in complex with a glucagon analogue NNC1702 reveals how the peptide ligand interacts with its target and shows the conformational changes required for receptor activation.

    • Haonan Zhang
    • Anna Qiao
    • Beili Wu
    Research
    Nature
    Volume: 553, P: 106-110