Nature Search

PSD3 downregulation confers protection against fatty liver disease

Employing a candidate gene approach, Mancina et al. identify a genetic variant of the Pleckstrin and Sec7 ___domain-containing 3 (PSD3) gene that reduces susceptibility to fatty liver disease. Functional studies in vitro and in vivo demonstrate that targeting PSD3 protects against fatty liver disease.

Rosellina M. Mancina
Kavitha Sasidharan
Stefano Romeo
ResearchOpen Access31 Jan 2022
Nature Metabolism

Volume: 4, P: 60-75
Blobby is a synaptic active zone assembly protein required for memory in Drosophila

The active zone is a brain signaling hub critical for synaptic information transfer and the encoding of behaviors. The authors identify Blobby as an assembly factor required for proper active zone nanoscale protein architecture and memory formation.

J. Lützkendorf
T. Matkovic-Rachid
S. J. Sigrist
ResearchOpen Access02 Jan 2025
Nature Communications

Volume: 16, P: 1-20
Discovery of common and rare genetic risk variants for colorectal cancer

Genome-wide association analyses based on whole-genome sequencing and imputation identify 40 new risk variants for colorectal cancer, including a strongly protective low-frequency variant at CHD1 and loci implicating signaling and immune function in disease etiology.

Jeroen R. Huyghe
Stephanie A. Bien
Ulrike Peters
Research03 Dec 2018
Nature Genetics

Volume: 51, P: 76-87
High-density genotyping study identifies four new susceptibility loci for atopic dermatitis

Andre Franke and colleagues perform an association study of atopic dermatitis based on high-density genotyping using the Immunochip array. They identify four new susceptibility loci for this common inflammatory skin disease.

David Ellinghaus
Hansjörg Baurecht
Stephan Weidinger
Research02 Jun 2013
Nature Genetics

Volume: 45, P: 808-812
Autophagy within the mushroom body protects from synapse aging in a non-cell autonomous manner

The role of macroautophagy in neuronal processes mediating brain maintenance remains enigmatic. Authors show here that impairing autophagy within the major learning related brain center of Drosophila, and not other regions, triggered a form of presynaptic metaplasticity that was invariably connected to the absence of the specific component of aversive olfactory memory, which normally only declines in the course of aging process

Anuradha Bhukel
Christine Brigitte Beuschel
Stephan J. Sigrist
ResearchOpen Access21 Mar 2019
Nature Communications

Volume: 10, P: 1-13
A genome-wide association study confirms PNPLA3 and identifies TM6SF2 and MBOAT7 as risk loci for alcohol-related cirrhosis

Felix Stickel and colleagues report the results of a genome-wide association study of alcohol-related cirrhosis. They confirm PNPLA3 as a susceptibility locus and identify new association signals in MBOAT7 and TM6SF2.

Stephan Buch
Felix Stickel
Jochen Hampe
Research19 Oct 2015
Nature Genetics

Volume: 47, P: 1443-1448
A genome-wide association scan identifies the hepatic cholesterol transporter ABCG8 as a susceptibility factor for human gallstone disease

Stephan Buch
Clemens Schafmayer
Jochen Hampe
Research15 Jul 2007
Nature Genetics

Volume: 39, P: 995-999
Proteomic profiling reveals CDK6 upregulation as a targetable resistance mechanism for lenalidomide in multiple myeloma

Acquired resistance to immunomodulatory drugs is common in multiple myeloma patients, but rarely attributed to genetic alterations. Here, proteomic, phosphoproteomic and RNA sequencing analysis in five paired pre-treatment and relapse samples reveals a CDK6-regulated protein resistance signature.

Yuen Lam Dora Ng
Evelyn Ramberger
Jan Krönke
ResearchOpen Access23 Feb 2022
Nature Communications

Volume: 13, P: 1-13
Defining the landscape of circular RNAs in neuroblastoma unveils a global suppressive function of MYCN

The role of circular RNAs (circRNAs) in modulating gene expression in cancer remains to be investigated. Here, the authors perform whole transcriptome sequencing in 104 primary neuroblastomas and reveal the involvement of MYCN in regulating circRNAs.

Steffen Fuchs
Clara Danßmann
Johannes H. Schulte
ResearchOpen Access04 Jul 2023
Nature Communications

Volume: 14, P: 1-21
Molecular dissection of colorectal cancer in pre-clinical models identifies biomarkers predicting sensitivity to EGFR inhibitors

The heterogeneity of colorectal cancer has important clinical and therapeutic implications. Here the authors analysed the responses of a large biobank of organoids and xenografts derived from colorectal patients to a panel of clinically relevant therapeutic agents to identify genes signatures associated with drug response.

Moritz Schütte
Thomas Risch
Marie-Laure Yaspo
ResearchOpen Access10 Feb 2017
Nature Communications

Volume: 8, P: 1-19
Intrinsic inhibition of transcription factor E2A by HLH proteins ABF-1 and Id2 mediates reprogramming of neoplastic B cells in Hodgkin lymphoma

Stephan Mathas
Martin Janz
Bernd Dörken
Research20 Dec 2005
Nature Immunology

Volume: 7, P: 207-215
Tuberculosis after hematopoietic cell transplantation: retrospective study on behalf of the Infectious Diseases Working Party of the EBMT

Joanna Drozd-Sokołowska
Gloria Tridello
Jan Styczynski
Research25 Feb 2025
Bone Marrow Transplantation

Volume: 60, P: 603-616
Correspondence: SEMA4A variation and risk of colorectal cancer

Ben Kinnersley
Daniel Chubb
Richard S. Houlston
CorrespondenceOpen Access10 Mar 2016
Nature Communications

Volume: 7, P: 1-3
Meta-analysis of genome-wide association data identifies four new susceptibility loci for colorectal cancer

Richard Houlston and colleagues identify four new susceptibility loci for colorectal cancer through a meta-analysis of genome-wide association data, followed by replication testing in a large collection of independent samples. The study brings to ten the number of confirmed loci harboring low-penetrance risk alleles for this common malignancy.

Richard S Houlston
Emily Webb
Malcolm G Dunlop
Research16 Nov 2008
Nature Genetics

Volume: 40, P: 1426-1435
A common variant on chromosome 11q13 is associated with atopic dermatitis

Young-Ae Lee and colleagues report results of a genome-wide association study for atopic dermatitis. They identify a risk locus on chromosome 11q13 in a region previously associated with risk of Crohn's disease.

Jorge Esparza-Gordillo
Stephan Weidinger
Andreas Ruether
Research06 Apr 2009
Nature Genetics

Volume: 41, P: 596-601
The translational potential of microRNAs as biofluid markers of urological tumours

MicroRNA secretion pathways are dysregulated in cancer, making them attractive candidate molecules for liquid biopsies and studies have shown that they are noninvasive diagnostic, prognostic and surveillance markers in urological carcinomas. However, methodological and analytical pitfalls exist and require addressing to enable future translation of microRNA analysis into clinical practice.

Annika Fendler
Carsten Stephan
Klaus Jung
Reviews02 Nov 2016
Nature Reviews Urology

Volume: 13, P: 734-752
Genome-wide association scan identifies a colorectal cancer susceptibility locus on 11q23 and replicates risk loci at 8q24 and 18q21

Albert Tenesa
Susan M Farrington
Malcolm G Dunlop
Research30 Mar 2008
Nature Genetics

Volume: 40, P: 631-637
A genome-wide association study identifies colorectal cancer susceptibility loci on chromosomes 10p14 and 8q23.3

Ian PM Tomlinson
Emily Webb
Richard S Houlston
Research30 Mar 2008
Nature Genetics

Volume: 40, P: 623-630
Epidemiology of 7375 children and adolescents hospitalized with COVID-19 in Germany, reported via a prospective, nationwide surveillance study in 2020–2022

Maren Doenhardt
Markus Hufnagel
Ulrich Zügge
ResearchOpen Access02 Jan 2024
Scientific Reports

Volume: 14, P: 1-15
Long-term follow-up of subcutaneous versus intravenous bortezomib during induction therapy for newly diagnosed multiple myeloma treated within the GMMG-MM5 Phase III Trial

Hans Salwender
Ahmet Elmaagacli
Hartmut Goldschmidt
Research24 May 2021
Leukemia

Volume: 35, P: 3007-3011
A comparison of pediatric inflammatory multisystem syndrome temporarily-associated with SARS-CoV-2 and Kawasaki disease

Markus Hufnagel
Jakob Armann
Ulrich Zügge
ResearchOpen Access20 Jan 2023
Scientific Reports

Volume: 13, P: 1-14
Whole Genome Sequence, Variant Discovery and Annotation in Mapuche-Huilliche Native South Americans

Elena A. Vidal
Tomás C. Moyano
Rodrigo A. Gutiérrez
ResearchOpen Access14 Feb 2019
Scientific Reports

Volume: 9, P: 1-11
Copy number variants in lipid metabolism genes are associated with gallstones disease in men

Eduardo Pérez-Palma
Bernabé I. Bustos
Giancarlo V. De Ferrari
ResearchOpen Access04 Sept 2019
European Journal of Human Genetics

Volume: 28, P: 264-273
Variants in ABCG8 and TRAF3 genes confer risk for gallstone disease in admixed Latinos with Mapuche Native American ancestry

Bernabé I. Bustos
Eduardo Pérez-Palma
Juan Francisco Miquel
ResearchOpen Access28 Jan 2019
Scientific Reports

Volume: 9, P: 1-12
Recurrent Coding Sequence Variation Explains Only A Small Fraction of the Genetic Architecture of Colorectal Cancer

Maria N. Timofeeva
Ben Kinnersley
Richard S. Houlston
ResearchOpen Access10 Nov 2015
Scientific Reports

Volume: 5, P: 1-10
Publisher Correction: Bortezomib-based induction, high-dose melphalan and lenalidomide maintenance in myeloma up to 70 years of age

Elias K. Mai
Kaya Miah
Hartmut Goldschmidt
Amendments and CorrectionsOpen Access16 Nov 2021
Leukemia

Volume: 35, P: 3636
Initial sequencing and analysis of the human genome

Eric S. Lander
Lauren M. Linton
Michael J. Morgan
articles01 Feb 2001
Nature

Volume: 409, P: 860-921
Bortezomib-based induction, high-dose melphalan and lenalidomide maintenance in myeloma up to 70 years of age

Elias K. Mai
Kaya Miah
Hartmut Goldschmidt
ResearchOpen Access20 Jul 2020
Leukemia

Volume: 35, P: 809-822
Lenalidomide versus bortezomib maintenance after frontline autologous stem cell transplantation for multiple myeloma

Marc-Andrea Baertsch
Elias K. Mai
Hartmut Goldschmidt
ResearchOpen Access07 Jan 2021
Blood Cancer Journal

Volume: 11, P: 1-10
CD79a promotes CNS-infiltration and leukemia engraftment in pediatric B-cell precursor acute lymphoblastic leukemia

Lenk et al find that the preB cell receptor (preBCR) is associated with infiltration and relapse of acute lymphoblastic leukemia in the central nervous system (CNS). They also show that downregulation of preBCR component CD79a reduces the engraftment of leukemia cells in different murine xenograft models, particularly in the CNS.

Lennart Lenk
Michela Carlet
Denis M. Schewe
ResearchOpen Access15 Jan 2021
Communications Biology

Volume: 4, P: 1-6
Response-adapted lenalidomide maintenance in newly diagnosed myeloma: results from the phase III GMMG-MM5 trial

Hartmut Goldschmidt
Elias K. Mai
Hans J. Salwender
Research07 Feb 2020
Leukemia

Volume: 34, P: 1853-1865
TFEB-mediated lysosomal biogenesis and lysosomal drug sequestration confer resistance to MEK inhibition in pancreatic cancer

Ben Zhao
Laura Dierichs
Smiths S. Lueong
ResearchOpen Access11 Mar 2020
Cell Death Discovery

Volume: 6, P: 1-13
Loss of the tissue-specific proapoptotic BH3-only protein Nbk/Bik is a unifying feature of renal cell carcinoma

I Sturm
C Stephan
P T Daniel
Research02 Dec 2005
Cell Death & Differentiation

Volume: 13, P: 619-627
YB-1 facilitates basal and 5-fluorouracil-inducible expression of the human major vault protein (MVP) gene

Ulrike Stein
Stephan Bergmann
Wolfgang Walther
Research07 Mar 2005
Oncogene

Volume: 24, P: 3606-3618
Standardized evaluation of tumor-infiltrating lymphocytes in breast cancer: results of the ring studies of the international immuno-oncology biomarker working group

Carsten Denkert
Stephan Wienert
Roberto Salgado
Research01 Jul 2016
Modern Pathology

Volume: 29, P: 1155-1164

Search

PSD3 downregulation confers protection against fatty liver disease

Blobby is a synaptic active zone assembly protein required for memory in Drosophila

Discovery of common and rare genetic risk variants for colorectal cancer

High-density genotyping study identifies four new susceptibility loci for atopic dermatitis

Autophagy within the mushroom body protects from synapse aging in a non-cell autonomous manner

A genome-wide association study confirms PNPLA3 and identifies TM6SF2 and MBOAT7 as risk loci for alcohol-related cirrhosis

A genome-wide association scan identifies the hepatic cholesterol transporter ABCG8 as a susceptibility factor for human gallstone disease

Proteomic profiling reveals CDK6 upregulation as a targetable resistance mechanism for lenalidomide in multiple myeloma

Defining the landscape of circular RNAs in neuroblastoma unveils a global suppressive function of MYCN

Molecular dissection of colorectal cancer in pre-clinical models identifies biomarkers predicting sensitivity to EGFR inhibitors

Intrinsic inhibition of transcription factor E2A by HLH proteins ABF-1 and Id2 mediates reprogramming of neoplastic B cells in Hodgkin lymphoma

Tuberculosis after hematopoietic cell transplantation: retrospective study on behalf of the Infectious Diseases Working Party of the EBMT

Correspondence: SEMA4A variation and risk of colorectal cancer

Meta-analysis of genome-wide association data identifies four new susceptibility loci for colorectal cancer

A common variant on chromosome 11q13 is associated with atopic dermatitis

The translational potential of microRNAs as biofluid markers of urological tumours

Genome-wide association scan identifies a colorectal cancer susceptibility locus on 11q23 and replicates risk loci at 8q24 and 18q21

A genome-wide association study identifies colorectal cancer susceptibility loci on chromosomes 10p14 and 8q23.3

Epidemiology of 7375 children and adolescents hospitalized with COVID-19 in Germany, reported via a prospective, nationwide surveillance study in 2020–2022

Long-term follow-up of subcutaneous versus intravenous bortezomib during induction therapy for newly diagnosed multiple myeloma treated within the GMMG-MM5 Phase III Trial

A comparison of pediatric inflammatory multisystem syndrome temporarily-associated with SARS-CoV-2 and Kawasaki disease

Whole Genome Sequence, Variant Discovery and Annotation in Mapuche-Huilliche Native South Americans

Copy number variants in lipid metabolism genes are associated with gallstones disease in men

Variants in ABCG8 and TRAF3 genes confer risk for gallstone disease in admixed Latinos with Mapuche Native American ancestry

Recurrent Coding Sequence Variation Explains Only A Small Fraction of the Genetic Architecture of Colorectal Cancer

Publisher Correction: Bortezomib-based induction, high-dose melphalan and lenalidomide maintenance in myeloma up to 70 years of age

Initial sequencing and analysis of the human genome

Bortezomib-based induction, high-dose melphalan and lenalidomide maintenance in myeloma up to 70 years of age

Lenalidomide versus bortezomib maintenance after frontline autologous stem cell transplantation for multiple myeloma

CD79a promotes CNS-infiltration and leukemia engraftment in pediatric B-cell precursor acute lymphoblastic leukemia

Response-adapted lenalidomide maintenance in newly diagnosed myeloma: results from the phase III GMMG-MM5 trial

TFEB-mediated lysosomal biogenesis and lysosomal drug sequestration confer resistance to MEK inhibition in pancreatic cancer

Loss of the tissue-specific proapoptotic BH3-only protein Nbk/Bik is a unifying feature of renal cell carcinoma

YB-1 facilitates basal and 5-fluorouracil-inducible expression of the human major vault protein (MVP) gene

Standardized evaluation of tumor-infiltrating lymphocytes in breast cancer: results of the ring studies of the international immuno-oncology biomarker working group

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