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Advanced filters: Author: Stephane Duflocq Clear advanced filters

  • A phenotypic screen led to the identification of potent inhibitors of mouse BAK-driven apoptosis. The compounds interact with VDAC2 and stabilize its interaction with BAK, blocking apoptosis at an early stage to preserve long-term cell survival.

    • Mark F. van Delft
    • Stephane Chappaz
    • Benjamin T. Kile
    Research
    Nature Chemical Biology
    Volume: 15, P: 1057-1066