Search

Understanding collective behaviour is an important aspect of managing the pandemic response. Here the authors show in a large global study that participants that reported identifying more strongly with their nation reported greater engagement in public health behaviours and support for public health policies in the context of the pandemic.

Polio remains a public health concern in Pakistan and Afghanistan and continuous surveillance is essential. Here, the authors analyse genetic sequence data collected from 2012-2023 and perform phylogeographic analyses to investigate virus spread, transmission routes, and trends in viral diversity and persistence.

The Somatic Mosaicism across Human Tissues Network aims to create a reference catalogue of somatic mosaicism across different tissues and cells within individuals.

Here, Rose et al show that Ca. M. amalyticus (Patescibacterium) infection and lysis depend on the presence of mycolic acid in its host bacterium Gordonia amarae.

Johannes Krause et al. synthesized seagrass carbon stock data from 2700+ soil cores to find that they vary by plant functional group and coastal setting, indicating where conservation efforts would most effectively avoid emissions from seagrass loss

The arcuate fascicle connection with the middle temporal gyrus has been considered unique to humans. Using high-resolution diffusion MRI, the authors systematically show this connection in chimpanzees, suggesting a gradual evolution of the language network.

Venous tumour thrombus can occur within renal cell carcinoma, and can require complex additional surgery and treatment. Here, the authors analyse multiparametric data from patients treated with axitinib and develop a machine learning model to predict neoadjuvant treatment response.

A generalizable, functional-trait-based approach for quantifying the effects of disturbances to ecosystem services and economic outcomes, including under climate change, highlights the need for incorporating disturbances in ecosystem services assessments.

There are limited approaches to monitor virus spread in vivo. Here, the authors report PET/CT-based in vivo imaging to track SARS-CoV-2 biodistribution in a COVID-19 non-human primate model using a radiolabeled human antibody revealing persistent detection in the lung and brain 3 months after infection.

A recent synthesis study found 54% of the high-latitude peatlands have been drying and 32% have been wetting over the past centuries, illustrating their complex ecohydrological dynamics and highly uncertain responses to a warming climate.

Genome-wide analysis and genetic manipulation at loci regulated by p53, E2F4 and RFX7 show that convergent promoters with similar epigenetic features can be co-regulated and simultaneously expressed in the same direction.

Interlayer coupling between two-dimensional materials is known to result in interesting physical properties. Here, the authors study the effect of a twist angle between two-dimensional molybdenum disulphide on interlayer coupling, observing an indirect bandgap, the size of which depends on the twist angle.

DNA methylation is an age biomarker, but nonlinear aspects of its age-related dynamics are not well characterized. Here, the authors identify loci that undergo sudden methylation changes at specific life stages in the aging colon of male mice.

Pulendran and colleagues define a molecular signature that can be used to predict the durability of antibody responses to vaccination and reveal important insights into the mechanisms by which vaccines induce durable immunity.

Steve Brown and colleagues report an analysis of 20 phenotyping tests, including 413 data parameters, across 449 mutant mouse alleles. They identify widespread pleiotropy and assign putative functions to genes that lacked previous phenotypic annotation.

The macroscopic mechanical response in cross-linked polymer networks has been well investigated but an understanding of pre-failure local mechanical responses at the level of individual crosslinks is still lacking. Here, using an extensophore concept, the authors show that the crosslinks in an elastic polymer network extend, fluctuate, and deform with a wide range of molecular individuality

Plastic pollution is an escalating problem and there is a need to predict the range of plastic sizes that an organism of interest could feasibly ingest. Here the authors use previously published data to develop an allometric equation for plastic size ingested as a function of animal body size, a relationship which could help predict risk of plastic introduction into food webs.

DeBerge, Glinton et al. demonstrate that allograft inflammatory factor 1 promotes inflammatory glycolytic reprogramming in cardiac macrophages, leading to adverse remodeling and progression to heart failure after myocardial infarction.

With the generation of large pan-cancer whole-exome and whole-genome sequencing projects, a question remains about how comparable these datasets are. Here, using The Cancer Genome Atlas samples analysed as part of the Pan-Cancer Analysis of Whole Genomes project, the authors explore the concordance of mutations called by whole exome sequencing and whole genome sequencing techniques.

Puigserver and colleagues show that genetic targeting of specific mitochondrial respiratory complex I subunits in melanoma and breast cancer cells boosts tumor immune surveillance via upregulation of antigen-processing and presentation components.

Fertility in polyploid species relies on pairing and recombination occurring only between true homologues rather than the diverged homoeologous chromosomes also present. Here, Martin et al.show that Ph1 stabilises polyploidy in wheat by promoting homologue pairing and preventing crossovers on paired homoeologues during meiosis.

Carcinoma subtypes are normally linked to specific genetic alterations, but tissue mechanical changes also play a role. Now, aberrant morphologies resembling bladder carcinoma are shown to emerge from stiffness changes during epithelial overgrowth.

A multi-model framework that accounts for climate, water, energy, food, biodiversity and economic activity in Australia reveals that a sustainable society that enjoys economic improvement without ecological deterioration is possible, but that specific political and economic choices need to be made to achieve this.

Conventional microscopy is unable to correlate nanoscale properties of metal halide perovskites with the performance of solar cells. Frohna et al. present a multimodal operando microscopy toolkit as a diagnostic tool to address the issue.

Whole-genome sequencing data from more than 2,500 cancers of 38 tumour types reveal 16 signatures that can be used to classify somatic structural variants, highlighting the diversity of genomic rearrangements in cancer.

A phase 2 randomized controlled trial of ustekinumab in 72 adolescents with recent-onset type 1 diabetes showed that treatment was well tolerated and β-cell function was 49% higher in the intervention group compared to the placebo arm after 12 months.

The changing built structure of cities reflects and affects social and environmental forces. Combining remotely sensed and other data, this study finds a global shift in the past three decades, with cities growing more vertically than horizontally.

By genetic studies the authors report a gene, Ppd-1, which controls paired spikelet development in wheat by regulating the expression of FT. Modulating the expression of Ppd-1 and FT can be used to improve grain-producing spikelets in wheat.

The efficiency of organic blends used for photovoltaic applications depends on their ability to convert photoexcited charges into free holes and electrons. It is now demonstrated that the lowermost energetic states formed at the donor/acceptor interface can reach conversion efficiencies close to 100%, and therefore do not behave as traps for charge carriers.