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Showing 1–7 of 7 results
Advanced filters: Author: Steven Ballet Clear advanced filters

  • Mutations in glucocerebrosidase lead to Parkinson’s and Gaucher disease. This study reports the characterization of nanobodies that improve glucocerebrosidase functionality using an allosteric mechanism. This paves the way for alternative therapeutic routes.

    • Thomas Dal Maso
    • Chiara Sinisgalli
    • Nicoletta Plotegher
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-19

  • Protein-protein interactions are central in cell metabolism but research tools for their characterization are missing. Here, the authors introduce strategies for the discovery of nanobodies that modulate the SOS1•RAS complex formation.

    • Baptiste Fischer
    • Tomasz UchaÅ„ski
    • Jan Steyaert
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-10

  • The µ-opioid receptor is a key clinical target. Here, the authors describe nanobody NbE, a selective and high affinity antagonist, which is downsized to small cyclic peptides. The work enables unique receptor targeting based on nanobody interaction.

    • Jun Yu
    • Amit Kumar
    • Miriam Stoeber
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-15

  • To avoid being eaten, poisonous prey animals must rely on fast passage of toxins across a predator’s oral tissue, a major barrier to large molecules. Here, Raaymakers et al. show that antimicrobial peptides co secreted with frog toxins enhance intoxication of a snake predator by permeabilizing oral cell layers.

    • Constantijn Raaymakers
    • Elin Verbrugghe
    • Kim Roelants
    ResearchOpen Access
    Nature Communications
    Volume: 8, P: 1-8

  • Serial femtosecond crystallography of the human δ-opioid receptor in complex with an endomorphin-derived peptide reveals interactions that are important for understanding the pharmacology of opioid peptides and developing analgesics with reduced side effects.

    • Gustavo Fenalti
    • Nadia A Zatsepin
    • Vadim Cherezov
    Research
    Nature Structural & Molecular Biology
    Volume: 22, P: 265-268