Nature Search

Inter-seasonal compressed-air energy storage using saline aquifers

Compressed-air energy storage could be a useful inter-seasonal storage resource to support highly renewable power systems. This study presents a modelling approach to assess the potential for such storage in porous rocks and, applying it to the UK, finds availability of up to 96 TWh in offshore saline aquifers.

Julien Mouli-Castillo
Mark Wilkinson
Zoe K. Shipton
Research21 Jan 2019
Nature Energy

Volume: 4, P: 131-139
Author Correction: Dose escalation and expansion cohorts in patients with advanced breast cancer in a Phase I study of the CDK7-inhibitor samuraciclib

R. C. Coombes
Sacha Howell
Matthew G. Krebs
Amendments and CorrectionsOpen Access06 Mar 2025
Nature Communications

Volume: 16, P: 1
Mapping the current landscape of locoregional therapy de-escalation trials in early breast cancer: a systematic review

Alan D. McCrorie
Hilary Stobart
Shelley Potter
ResearchOpen Access30 Mar 2025
npj Breast Cancer

Volume: 11, P: 1-11
Dose escalation and expansion cohorts in patients with advanced breast cancer in a Phase I study of the CDK7-inhibitor samuraciclib

Pre-clinical studies have demonstrated the anti-tumor activity of selective inhibitors of CDK7, including samuraciclib. Here the authors report the results from dose escalation and two expansion cohorts in patients with breast cancer of a multi-modular Phase I clinical trial of samuraciclib as anti-cancer treatment.

R. C. Coombes
Sacha Howell
Matthew G. Krebs
ResearchOpen Access24 Jul 2023
Nature Communications

Volume: 14, P: 1-10
A multisystem, cardio-renal investigation of post-COVID-19 illness

Deep clinical phenotyping at 28–60 days post-discharge of patients who had been hospitalized with COVID-19 and subsequent long-term follow-up with electronic health records reveal evidence of persistent cardio-renal involvement.

Andrew J. Morrow
Robert Sykes
Colin Berry
ResearchOpen Access23 May 2022
Nature Medicine

Volume: 28, P: 1303-1313
Orbitally induced oscillations in the East Antarctic ice sheet at the Oligocene/Miocene boundary

Tim R. Naish
Ken J. Woolfe
Thomas Wonik
Research18 Oct 2001
Nature

Volume: 413, P: 719-723
Para-infectious brain injury in COVID-19 persists at follow-up despite attenuated cytokine and autoantibody responses

COVID-19 can be associated with neurological complications. Here the authors show that markers of brain injury, but not immune markers, are elevated in the blood of patients with COVID-19 both early and months after SARS-CoV-2 infection, particularly in those with brain dysfunction or neurological diagnoses.

Benedict D. Michael
Cordelia Dunai
David K. Menon
ResearchOpen Access22 Dec 2023
Nature Communications

Volume: 14, P: 1-15
Timing of whole genome duplication is associated with tumor-specific MHC-II depletion in serous ovarian cancer

There is high prevalence of whole genome duplication (WGD) in high grade serous ovarian cancer. Here, the authors compare tumours with and without WGD and find that those that acquired WGD early during tumour evolution are associated with worse survival and have the lowest expression of MHC-II.

Nikki L. Burdett
Madelynne O. Willis
Elizabeth L. Christie
ResearchOpen Access18 Jul 2024
Nature Communications

Volume: 15, P: 1-13
Study of 300,486 individuals identifies 148 independent genetic loci influencing general cognitive function

Cognitive function is associated with health and important life outcomes. Here, the authors perform a genome-wide association study for general cognitive function in 300,486 individuals and identify genetic loci that implicate neural and cell developmental pathways in this trait.

Gail Davies
Max Lam
Ian J. Deary
ResearchOpen Access29 May 2018
Nature Communications

Volume: 9, P: 1-16
EFFECTS OF HYDROGEN PEROXIDE (H₂O₂) ON PROSTACYCLIN AND OTHER VASCULAR ARACHIDONIC ACID METABOLITES

B N Y Setty
Elizabeth Jurek
Marie Stuart
Research01 Apr 1984
Pediatric Research

Volume: 18, P: 285
Exome sequencing in bipolar disorder identifies AKAP11 as a risk gene shared with schizophrenia

Exome sequencing analysis of 13,933 individuals with bipolar disorder finds enrichment of ultra-rare protein-truncating variants in constrained genes. Combined analysis with schizophrenia exome data identifies AKAP11 as a risk gene for both disorders.

Duncan S. Palmer
Daniel P. Howrigan
Benjamin M. Neale
Research11 Apr 2022
Nature Genetics

Volume: 54, P: 541-547
Author Correction: Dose escalation and expansion cohorts in patients with advanced breast cancer in a Phase I study of the CDK7-inhibitor samuraciclib

R. C. Coombes
Sacha Howell
Matthew G. Krebs
Amendments and CorrectionsOpen Access07 Aug 2023
Nature Communications

Volume: 14, P: 1
Genome-wide analysis identifies molecular systems and 149 genetic loci associated with income

Household income is used as a marker of socioeconomic position, a trait that is associated with better physical and mental health. Here, Hill et al. report a genome-wide association study for household income in the UK and explore its relationship with intelligence in post-GWAS analyses including Mendelian randomization.

W. David Hill
Neil M. Davies
Ian J. Deary
ResearchOpen Access16 Dec 2019
Nature Communications

Volume: 10, P: 1-16
Genomic structural equation modelling provides insights into the multivariate genetic architecture of complex traits

Grotzinger et al. develop a multivariate method for analysing the joint genetic architectures of complex traits: genomic structural equation modelling. They provide several applications of the method, including a joint analysis of five psychiatric traits.

Andrew D. Grotzinger
Mijke Rhemtulla
Elliot M. Tucker-Drob
Research08 Apr 2019
Nature Human Behaviour

Volume: 3, P: 513-525
Large-scale phenotyping of patients with long COVID post-hospitalization reveals mechanistic subtypes of disease

Openshaw and colleagues find myeloid inflammation and complement activation signatures in patients with long COVID who were previously hospitalized.

Felicity Liew
Claudia Efstathiou
J. Eunice Zhang
ResearchOpen Access08 Apr 2024
Nature Immunology

Volume: 25, P: 607-621
Impact of mutational profiles on response of primary oestrogen receptor-positive breast cancers to oestrogen deprivation

Aromatase inhibitors are used to treat oestrogen receptor positive breast cancers but the molecular basis for the response of patients is unclear. Here, the authors use samples from an aromatase inhibitor clinical trial and show that tumours from poor responders have more mutations than good responders and also more frequently harbour p53 mutations.

Pascal Gellert
Corrinne V. Segal
Peter Donnelly
ResearchOpen Access09 Nov 2016
Nature Communications

Volume: 7, P: 1-11
Breast cancer management pathways during the COVID-19 pandemic: outcomes from the UK ‘Alert Level 4’ phase of the B-MaP-C study

Rajiv V. Dave
Baek Kim
Zaid Al-Ishaq
ResearchOpen Access25 Mar 2021
British Journal of Cancer

Volume: 124, P: 1785-1794
Author Correction: Para-infectious brain injury in COVID-19 persists at follow-up despite attenuated cytokine and autoantibody responses

Benedict D. Michael
Cordelia Dunai
David K. Menon
Amendments and CorrectionsOpen Access04 Apr 2024
Nature Communications

Volume: 15, P: 1
The impact of immediate breast reconstruction on the time to delivery of adjuvant therapy: the iBRA-2 study

Rachel L O’Connell
Tim Rattay
Mohammed Mustafa
ResearchOpen Access29 Mar 2019
British Journal of Cancer

Volume: 120, P: 883-895
Methylation of all BRCA1 copies predicts response to the PARP inhibitor rucaparib in ovarian carcinoma

Around 10% of high-grade serous ovarian carcinomas (HGSOC) harbor BRCA1 promoter methylation, but it is uncertain how it predicts response to PARP inhibition. Here, the authors show that homozygous BRCA1 methylation predicts response to rucaparib while heterozygous methylation of BRCA1 predicts resistance in HGSOC.

Olga Kondrashova
Monique Topp
Clare L. Scott
ResearchOpen Access28 Sept 2018
Nature Communications

Volume: 9, P: 1-16
Author Correction: Study of 300,486 individuals identifies 148 independent genetic loci influencing general cognitive function

Gail Davies
Max Lam
Ian J. Deary
Amendments and CorrectionsOpen Access01 May 2019
Nature Communications

Volume: 10, P: 1-5
Activation of a cGAS-STING-mediated immune response predicts response to neoadjuvant chemotherapy in early breast cancer

Eileen E. Parkes
Kienan I. Savage
Stuart A. McIntosh
ResearchOpen Access02 Nov 2021
British Journal of Cancer

Volume: 126, P: 247-258
Refined cut-off for TP53 immunohistochemistry improves prediction of TP53 mutation status in ovarian mucinous tumors: implications for outcome analyses

Eun Young Kang
Dane Cheasley
Kylie L. Gorringe
Research28 Jul 2020
Modern Pathology

Volume: 34, P: 194-206
Gene and pathway level analyses of germline DNA-repair gene variants and prostate cancer susceptibility using the iCOGS-genotyping array

Edward J Saunders
Tokhir Dadaev
Zsofia Kote-Jarai
ResearchOpen Access10 Mar 2016
British Journal of Cancer

Volume: 114, P: 945-952
Evaluation of an artificial intelligence-based medical device for diagnosis of autism spectrum disorder

Jonathan T. Megerian
Sangeeta Dey
Sharief Taraman
ResearchOpen Access05 May 2022
npj Digital Medicine

Volume: 5, P: 1-11
Small-scale mutations are infrequent as mechanisms of resistance in post-PARP inhibitor tumour samples in high grade serous ovarian cancer

Nikki L. Burdett
Madelynne O. Willis
Elizabeth L. Christie
ResearchOpen Access11 Dec 2023
Scientific Reports

Volume: 13, P: 1-10
Correction: Breast cancer management pathways during the COVID-19 pandemic: outcomes from the UK ‘Alert Level 4’ phase of the B-MaP-C study

Rajiv V. Dave
Baek Kim
Cliona C. Kirwan
Amendments and CorrectionsOpen Access12 Apr 2021
British Journal of Cancer

Volume: 125, P: 772
Publisher Correction: Breast cancer management pathways during the COVID-19 pandemic: outcomes from the UK ‘Alert Level 4’ phase of the B-MaP-C study

Rajiv V. Dave
Baek Kim
Cliona C. Kirwan
Amendments and CorrectionsOpen Access23 Jun 2021
British Journal of Cancer

Volume: 125, P: 905
Paclitaxel sensitivity in relation to ABCB1 expression, efflux and single nucleotide polymorphisms in ovarian cancer

Bo Gao
Amanda Russell
Anna deFazio
ResearchOpen Access09 May 2014
Scientific Reports

Volume: 4, P: 1-9

Search

Inter-seasonal compressed-air energy storage using saline aquifers

Author Correction: Dose escalation and expansion cohorts in patients with advanced breast cancer in a Phase I study of the CDK7-inhibitor samuraciclib

Mapping the current landscape of locoregional therapy de-escalation trials in early breast cancer: a systematic review

Dose escalation and expansion cohorts in patients with advanced breast cancer in a Phase I study of the CDK7-inhibitor samuraciclib

A multisystem, cardio-renal investigation of post-COVID-19 illness

Orbitally induced oscillations in the East Antarctic ice sheet at the Oligocene/Miocene boundary

Para-infectious brain injury in COVID-19 persists at follow-up despite attenuated cytokine and autoantibody responses

Timing of whole genome duplication is associated with tumor-specific MHC-II depletion in serous ovarian cancer

Study of 300,486 individuals identifies 148 independent genetic loci influencing general cognitive function

EFFECTS OF HYDROGEN PEROXIDE (H₂O₂) ON PROSTACYCLIN AND OTHER VASCULAR ARACHIDONIC ACID METABOLITES

Exome sequencing in bipolar disorder identifies AKAP11 as a risk gene shared with schizophrenia

Author Correction: Dose escalation and expansion cohorts in patients with advanced breast cancer in a Phase I study of the CDK7-inhibitor samuraciclib

Genome-wide analysis identifies molecular systems and 149 genetic loci associated with income

Genomic structural equation modelling provides insights into the multivariate genetic architecture of complex traits

Large-scale phenotyping of patients with long COVID post-hospitalization reveals mechanistic subtypes of disease

Impact of mutational profiles on response of primary oestrogen receptor-positive breast cancers to oestrogen deprivation

Breast cancer management pathways during the COVID-19 pandemic: outcomes from the UK ‘Alert Level 4’ phase of the B-MaP-C study

Author Correction: Para-infectious brain injury in COVID-19 persists at follow-up despite attenuated cytokine and autoantibody responses

The impact of immediate breast reconstruction on the time to delivery of adjuvant therapy: the iBRA-2 study

Methylation of all BRCA1 copies predicts response to the PARP inhibitor rucaparib in ovarian carcinoma

Author Correction: Study of 300,486 individuals identifies 148 independent genetic loci influencing general cognitive function

Activation of a cGAS-STING-mediated immune response predicts response to neoadjuvant chemotherapy in early breast cancer

Refined cut-off for TP53 immunohistochemistry improves prediction of TP53 mutation status in ovarian mucinous tumors: implications for outcome analyses

Gene and pathway level analyses of germline DNA-repair gene variants and prostate cancer susceptibility using the iCOGS-genotyping array

Evaluation of an artificial intelligence-based medical device for diagnosis of autism spectrum disorder

Small-scale mutations are infrequent as mechanisms of resistance in post-PARP inhibitor tumour samples in high grade serous ovarian cancer

Correction: Breast cancer management pathways during the COVID-19 pandemic: outcomes from the UK ‘Alert Level 4’ phase of the B-MaP-C study

Publisher Correction: Breast cancer management pathways during the COVID-19 pandemic: outcomes from the UK ‘Alert Level 4’ phase of the B-MaP-C study

Paclitaxel sensitivity in relation to ABCB1 expression, efflux and single nucleotide polymorphisms in ovarian cancer

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