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Showing 1–7 of 7 results

Advanced filters: Author: Su-Yu Ji Clear advanced filters

Structure insights into selective coupling of G protein subtypes by a class B G protein-coupled receptor

Here, the authors report structures of corticotropin releasing factor receptor 2 (CRF2R) bound to agonist Urocortin 1 (UCN1) and coupled to G proteins G₁₁ and G_o, offering insight into the structural basis for the ability of CRF2R to couple with multiple G protein subtypes.

Li-Hua Zhao
Jingyu Lin
H. Eric Xu
ResearchOpen Access05 Nov 2022
Nature Communications

Volume: 13, P: 1-13
Molecular mechanism of agonism and inverse agonism in ghrelin receptor

Ghrelin receptor regulates energy homeostasis through constitutive activity or by the ghrelin. Here the authors report two structures of ghrelin receptor bound to agonist and inverse agonist, providing insights into the mechanism of inverse agonism, which is of interest for specific ligand design.

Jiao Qin
Ye Cai
Zhenhua Shao
ResearchOpen Access13 Jan 2022
Nature Communications

Volume: 13, P: 1-11
Molecular insights into the activation mechanism of GPR156 in maintaining auditory function

GPR156 has been identified as a regulator in auditory hair cells. Here, authors present the cryo-EM structures of human apo GPR156 and the GPR156–G_i3 complex to reveal the activation mechanism of GPR156 in maintaining auditory function.

Xiangyu Ma
Li-Nan Chen
Renjie Chai
ResearchOpen Access05 Dec 2024
Nature Communications

Volume: 15, P: 1-16
Structural insights into human brain–gut peptide cholecystokinin receptors

Yu Ding
Huibing Zhang
Xiao-Ming Li
ResearchOpen Access07 Jun 2022
Cell Discovery

Volume: 8, P: 1-16
Molecular basis for the activation of thyrotropin-releasing hormone receptor

Su-Yu Ji
Ying-Jun Dong
Chunyou Mao
CorrespondenceOpen Access25 Oct 2022
Cell Discovery

Volume: 8, P: 1-4
A novel role of microRNA 17-5p in the modulation of circadian rhythm

Qian Gao
Lan Zhou
Ji-Min Cao
ResearchOpen Access21 Jul 2016
Scientific Reports

Volume: 6, P: 1-12
Structures of the endogenous peptide- and selective non-peptide agonist-bound SSTR2 signaling complexes

Li-Nan Chen
Wei-Wei Wang
Chunyou Mao
Correspondence16 May 2022
Cell Research

Volume: 32, P: 785-788