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Enhancing transcription–replication conflict targets ecDNA-positive cancers

Extrachromosomal DNA makes cancerous tumours resistant to treatment, but this research demonstrates that increasing transcription–replication conflict allows for targeted elimination of cancer cells containing extrachromosomal DNA, and thus sustained tumour regression in mice.

Jun Tang
Natasha E. Weiser
Howard Y. Chang
ResearchOpen Access06 Nov 2024
Nature

Volume: 635, P: 210-218
Neuronal development is promoted by weakened intrinsic antioxidant defences due to epigenetic repression of Nrf2

Neurons in the brain are more susceptible to oxidative stress than astroglial cells but the molecular basis and biological reasons for this are poorly understood. Here the authors show that developing cortical neurons have reduced levels of the antioxidant transcription factor Nrf2 due to epigenetic silencing and that this is necessary for proper neuronal development.

Karen F.S. Bell
Bashayer Al-Mubarak
Giles E. Hardingham
ResearchOpen Access13 May 2015
Nature Communications

Volume: 6, P: 1-15
Altered cellular metabolism in gliomas — an emerging landscape of actionable co-dependency targets

This Review discusses altered cellular metabolism in gliomas, with particular regard to the interaction between tumour genotype and the brain microenvironment, and how advances in studying glioma metabolism have contributed to the discovery of potential drug targets.

Junfeng Bi
Sudhir Chowdhry
Paul S. Mischel
Reviews05 Dec 2019
Nature Reviews Cancer

Volume: 20, P: 57-70
NAD metabolic dependency in cancer is shaped by gene amplification and enhancer remodelling

NAD metabolic pathway choice in cancer is largely dependent on the tissue of origin, with implications for the development of precision treatments.

Sudhir Chowdhry
Ciro Zanca
Paul S. Mischel
Research24 Apr 2019
Nature

Volume: 569, P: 570-575

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Enhancing transcription–replication conflict targets ecDNA-positive cancers

Neuronal development is promoted by weakened intrinsic antioxidant defences due to epigenetic repression of Nrf2

Altered cellular metabolism in gliomas — an emerging landscape of actionable co-dependency targets

NAD metabolic dependency in cancer is shaped by gene amplification and enhancer remodelling

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