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Showing 1–4 of 4 results
Advanced filters: Author: Suihan Feng Clear advanced filters

  • The authors show the dimeric structure of human LYCHOS (lysosomal cholesterol signaling), a fusion of a transporter and a G-protein-coupled receptor-like ___domain. The study uncovers unique transporter and receptor features and proposes a mechanism to couple cholesterol sensing, transport and signaling.

    • Qi Xiong
    • Zhini Zhu
    • Dianfan Li
    Research
    Nature Structural & Molecular Biology
    Volume: 32, P: 905-913

  • A photoswitchable analog of spingosine-1-phosphate (S1P) that allows for modulation of the action of this bioactive lipid exhibits prolonged metabolic stability compared to S1P, activates S1P receptors in cells and mediates nociception in mice.

    • Johannes Morstein
    • Rose Z. Hill
    • Dirk Trauner
    Research
    Nature Chemical Biology
    Volume: 15, P: 623-631

  • Caged signalling intermediates are powerful cell biological tools, however it can be challenging to precisely control where activation occurs. Nadler et al. develop a caging group that specifically targets the plasma membrane, and demonstrate spatially controlled activation of arachidonic acid signalling.

    • André Nadler
    • Dmytro A. Yushchenko
    • Carsten Schultz
    ResearchOpen Access
    Nature Communications
    Volume: 6, P: 1-10

  • Through the use of a reversible chemical dimerizer, the splicing factor PRPF38A is re-localized to the nuclear lamina, paving the way for a systematic analysis of spatio-temporal splicing regulation.

    • Karen Vester
    • Marco Preußner
    • Markus C. Wahl
    ResearchOpen Access
    Communications Biology
    Volume: 5, P: 1-14